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GPR171 G protein-coupled receptor 171 [ Homo sapiens (human) ]

Gene ID: 29909, updated on 5-Mar-2024

Summary

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Official Symbol
GPR171provided by HGNC
Official Full Name
G protein-coupled receptor 171provided by HGNC
Primary source
HGNC:HGNC:30057
See related
Ensembl:ENSG00000174946 MIM:618925; AllianceGenome:HGNC:30057
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H963
Summary
Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within negative regulation of myeloid cell differentiation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in appendix (RPKM 5.9), lymph node (RPKM 4.6) and 12 other tissues See more
Orthologs
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Genomic context

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Location:
3q25.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (151197754..151203216, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (153948805..153954267, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (150915619..150921003, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CLRN1 antisense RNA 1 Neighboring gene uncharacterized LOC124909448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14822 Neighboring gene Sharpr-MPRA regulatory region 19 Neighboring gene mediator complex subunit 12L Neighboring gene RNA, 5S ribosomal pseudogene 145 Neighboring gene Sharpr-MPRA regulatory region 7583 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:150959259-150959858 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:150959859-150960456 Neighboring gene purinergic receptor P2Y14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20700 Neighboring gene Sharpr-MPRA regulatory region 3159 Neighboring gene SET pseudogene 11 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:151033994-151035193 Neighboring gene G protein-coupled receptor 87

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GPR171 expression enhances proliferation and metastasis of lung cancer cells. Dho SH, et al. Oncotarget, 2016 Feb 16. PMID 26760963, Free PMC Article
  2. A genetic selection for isolating cDNAs encoding secreted proteins. Jacobs KA, et al. Gene, 1997 Oct 1. PMID 9370294
  3. GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. Gomes I, et al. Proc Natl Acad Sci U S A, 2013 Oct 1. PMID 24043826, Free PMC Article
  4. Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. Joensuu T, et al. Am J Hum Genet, 2001 Oct. PMID 11524702, Free PMC Article
  5. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. Macaulay IC, et al. Blood, 2007 Apr 15. PMID 17192395, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High GPR171 expression enhances proliferation and metastasis of lung cancer.
    Title: GPR171 expression enhances proliferation and metastasis of lung cancer cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables G protein-coupled purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables neuropeptide binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables neuropeptide receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of myeloid cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of feeding behavior ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 171
Names
F730001G15Rik
G-protein coupled receptor H963
platelet activating receptor homolog
probable G-protein coupled receptor 171

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013308.4 → NP_037440.3  G-protein coupled receptor 171

    See identical proteins and their annotated locations for NP_037440.3

    Status: VALIDATED

    Source sequence(s)
    AA353758, AC078816, AF002986, BC036815
    Consensus CDS
    CCDS3155.1
    UniProtKB/Swiss-Prot
    D3DNJ4, O14626, Q8IV06
    Related
    ENSP00000308479.5, ENST00000309180.6
    Conserved Domains (1) summary
    cd15167
    Location:15 → 296
    7tmA_GPR171; orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    151197754..151203216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448056.1 → XP_047304012.1  G-protein coupled receptor 171 isoform X1

    UniProtKB/Swiss-Prot
    D3DNJ4, O14626, Q8IV06

  2. XM_005247402.4 → XP_005247459.1  G-protein coupled receptor 171 isoform X1

    See identical proteins and their annotated locations for XP_005247459.1

    UniProtKB/Swiss-Prot
    D3DNJ4, O14626, Q8IV06
    Related
    ENSP00000482588.1, ENST00000617554.1
    Conserved Domains (1) summary
    cd15167
    Location:15 → 296
    7tmA_GPR171; orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_047448054.1 → XP_047304010.1  G-protein coupled receptor 171 isoform X1

    UniProtKB/Swiss-Prot
    D3DNJ4, O14626, Q8IV06

  4. XM_005247403.4 → XP_005247460.1  G-protein coupled receptor 171 isoform X1

    See identical proteins and their annotated locations for XP_005247460.1

    UniProtKB/Swiss-Prot
    D3DNJ4, O14626, Q8IV06
    Conserved Domains (1) summary
    cd15167
    Location:15 → 296
    7tmA_GPR171; orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. XM_047448055.1 → XP_047304011.1  G-protein coupled receptor 171 isoform X1

    UniProtKB/Swiss-Prot
    D3DNJ4, O14626, Q8IV06

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    153948805..153954267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346389.1 → XP_054202364.1  G-protein coupled receptor 171 isoform X1

    UniProtKB/Swiss-Prot
    D3DNJ4, O14626, Q8IV06

  2. XM_054346385.1 → XP_054202360.1  G-protein coupled receptor 171 isoform X1

    UniProtKB/Swiss-Prot
    D3DNJ4, O14626, Q8IV06

  3. XM_054346386.1 → XP_054202361.1  G-protein coupled receptor 171 isoform X1

    UniProtKB/Swiss-Prot
    D3DNJ4, O14626, Q8IV06

  4. XM_054346388.1 → XP_054202363.1  G-protein coupled receptor 171 isoform X1

    UniProtKB/Swiss-Prot
    D3DNJ4, O14626, Q8IV06

  5. XM_054346387.1 → XP_054202362.1  G-protein coupled receptor 171 isoform X1

    UniProtKB/Swiss-Prot
    D3DNJ4, O14626, Q8IV06
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14626.1 GenPept UniProtKB/Swiss-Prot:O14626

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