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Arhgap5 Rho GTPase activating protein 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299012, updated on 3-Apr-2024

Summary

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Official Symbol
Arhgap5provided by RGD
Official Full Name
Rho GTPase activating protein 5provided by RGD
Primary source
RGD:1308507
See related
Ensembl:ENSRNOG00000004696 AllianceGenome:RGD:1308507
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LRRGT00098
Summary
Predicted to enable SH2 domain binding activity. Involved in mammary gland development. Predicted to be active in cytosol and endoplasmic reticulum. Orthologous to human ARHGAP5 (Rho GTPase activating protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 346.5), Kidney (RPKM 278.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arhgap5 in Genome Data Viewer
Location:
6q23
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (75711199..75774636)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (69975904..70039299)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (73345129..73408304)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ceramide synthase 5, pseudogene 1 Neighboring gene uncharacterized LOC134479384 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Silencing of the circ-Arhgap5 RNA protects neuronal PC12 cells against injury and depends on the miR-29a-3p/Rock1 axis. Wang S, et al. Metab Brain Dis, 2023 Apr. PMID 36790698
  2. P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis. McHenry PR, et al. Breast Cancer Res, 2010. PMID 20860838, Free PMC Article
  3. Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression. Heckman-Stoddard BM, et al. Breast Cancer Res, 2009. PMID 19703301, Free PMC Article
  4. P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer. Chakravarty G, et al. Cell Growth Differ, 2000 Jul. PMID 10939588
  5. MiR-744 functions as a proto-oncogene in nasopharyngeal carcinoma progression and metastasis via transcriptional control of ARHGAP5. Fang Y, et al. Oncotarget, 2015 May 30. PMID 25961434, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing of the circ-Arhgap5 RNA protects neuronal PC12 cells against injury and depends on the miR-29a-3p/Rock1 axis.
    Title: Silencing of the circ-Arhgap5 RNA protects neuronal PC12 cells against injury and depends on the miR-29a-3p/Rock1 axis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in mammary gland development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within mammary gland development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell size IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell size ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399400.1 → NP_001386329.1  rho GTPase-activating protein 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6HBI5
    Conserved Domains (5) summary
    smart00441
    Location:428 → 481
    FF; Contains two conserved F residues
    cd04373
    Location:1261 → 1445
    RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...
    pfam16512
    Location:260 → 338
    RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
    cd22220
    Location:592 → 762
    pseudoGTPaseD_p190RhoGAP-B; pseudoGTPase domain found in p190RhoGAP-B and similar proteins
    cl38936
    Location:31 → 246
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    75711199..75774636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111971.2 → XP_038967899.1  rho GTPase-activating protein 5 isoform X1

    UniProtKB/TrEMBL
    A6HBI5, E9PTJ5, Q6TUE6
    Conserved Domains (5) summary
    smart00441
    Location:428 → 481
    FF; Contains two conserved F residues
    cd04373
    Location:1261 → 1445
    RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...
    pfam16512
    Location:260 → 338
    RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
    cd22220
    Location:592 → 762
    pseudoGTPaseD_p190RhoGAP-B; pseudoGTPase domain found in p190RhoGAP-B and similar proteins
    cl38936
    Location:31 → 246
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_017594084.3 → XP_017449573.1  rho GTPase-activating protein 5 isoform X1

    UniProtKB/TrEMBL
    A6HBI5, E9PTJ5, Q6TUE6
    Conserved Domains (5) summary
    smart00441
    Location:428 → 481
    FF; Contains two conserved F residues
    cd04373
    Location:1261 → 1445
    RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...
    pfam16512
    Location:260 → 338
    RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
    cd22220
    Location:592 → 762
    pseudoGTPaseD_p190RhoGAP-B; pseudoGTPase domain found in p190RhoGAP-B and similar proteins
    cl38936
    Location:31 → 246
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_063261673.1 → XP_063117743.1  rho GTPase-activating protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K7N9

  4. XM_039111972.2 → XP_038967900.1  rho GTPase-activating protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K7N9, E9PTJ5, Q6TUE6
    Related
    ENSRNOP00000074284.2
    Conserved Domains (5) summary
    smart00441
    Location:428 → 481
    FF; Contains two conserved F residues
    cd04373
    Location:1260 → 1444
    RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...
    pfam16512
    Location:260 → 338
    RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
    cd22220
    Location:592 → 762
    pseudoGTPaseD_p190RhoGAP-B; pseudoGTPase domain found in p190RhoGAP-B and similar proteins
    cl38936
    Location:31 → 246
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001047869.1: Suppressed sequence

    Description
    NM_001047869.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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