Gpr22 G protein-coupled receptor 22 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr22provided by RGD
Official Full Name: G protein-coupled receptor 22provided by RGD
Primary source: RGD:1310848
See related: Ensembl:ENSRNOG00000008423 AllianceGenome:RGD:1310848
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G protein-coupled receptor activity and peptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in plasma membrane. Orthologous to human GPR22 (G protein-coupled receptor 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 263.0), Brain (RPKM 155.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (54037998..54044994, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (48309619..48317864, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (51012421..51021253, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

orphan receptors GPR22 and GPR162 are expressed in a different way in heart, kidney, brain and aorta of diabetic and non-diabetic rats. We conclude that orphan receptors could be involved in the development of diabetes complications.
Title: Expression of orphan receptors GPR22 and GPR162 in streptozotocin-induced diabetic rats.
Demonstrate GRR22 expression in rat heart.
Title: Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor.

Submit: New GeneRIF Correction

General gene information

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Markers

RH144397 (e-PCR)
- UniSTS:233642

BF412679 (e-PCR)
- UniSTS:248273

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G-protein coupled receptor 22

Names: probable G-protein coupled receptor 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106722.1 → NP_001100192.1 G-protein coupled receptor 22

See identical proteins and their annotated locations for NP_001100192.1

Status: PROVISIONAL

Source sequence(s)

CH473947

UniProtKB/Swiss-Prot

D4A3U0

UniProtKB/TrEMBL

A0A5H1ZRU0

Related

ENSRNOP00000011659.5, ENSRNOT00000011659.7

Conserved Domains (1) summary

cd00637
Location:81 → 406

7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

54037998..54044994 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111962.2 → XP_038967890.1 G-protein coupled receptor 22 isoform X1

UniProtKB/Swiss-Prot

D4A3U0

UniProtKB/TrEMBL

A0A5H1ZRU0

Conserved Domains (1) summary

cd00637
Location:81 → 406

7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily