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Mapk12 mitogen-activated protein kinase 12 [ Mus musculus (house mouse) ]

Gene ID: 29857, updated on 11-Apr-2024

Summary

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Official Symbol
Mapk12provided by MGI
Official Full Name
mitogen-activated protein kinase 12provided by MGI
Primary source
MGI:MGI:1353438
See related
Ensembl:ENSMUSG00000022610 AllianceGenome:MGI:1353438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Erk6; Sapk3; Prkm12; P38gamma
Summary
Predicted to enable ATP binding activity; MAP kinase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including intracellular signal transduction; myoblast differentiation; and peptidyl-serine phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in cap mesenchyme; lung mesenchyme; metanephros; and olfactory epithelium. Orthologous to human MAPK12 (mitogen-activated protein kinase 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 12.5), bladder adult (RPKM 9.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Mapk12 in Genome Data Viewer
Location:
15 E3; 15 44.65 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89014787..89025270, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89130584..89141577, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene selenoprotein O Neighboring gene tubulin, gamma complex component 6 Neighboring gene STARR-positive B cell enhancer ABC_E5508 Neighboring gene histone deacetylase 10 Neighboring gene STARR-positive B cell enhancer ABC_E8605 Neighboring gene mitogen-activated protein kinase 11 Neighboring gene plexin B2 Neighboring gene microRNA 7118

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. p38γ MAPK is required for inflammation-associated colon tumorigenesis. Yin N, et al. Oncogene, 2016 Feb 25. PMID 25961922
  2. Selective inhibition of ATPase activity during contraction alters the activation of p38 MAP kinase isoforms in skeletal muscle. Brault JJ, et al. J Cell Biochem, 2013 Jun. PMID 23296747, Free PMC Article
  3. p38γ regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage. Wu CC, et al. Protein Cell, 2010 Jun. PMID 21170151, Free PMC Article
  4. p38-{gamma}-dependent gene silencing restricts entry into the myogenic differentiation program. Gillespie MA, et al. J Cell Biol, 2009 Dec 28. PMID 20026657, Free PMC Article
  5. Effect of Thyroxine on the Structural and Dynamic Features of Cardiac Mitochondria and Mitophagy in Rats. Venediktova N, et al. Cells, 2023 Jan 21. PMID 36766738, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. p38gamma and p38delta modulate innate immune response by regulating MEF2D activation.
    Title: p38γ and p38δ modulate innate immune response by regulating MEF2D activation.
  2. Effect of Thyroxine on the Structural and Dynamic Features of Cardiac Mitochondria and Mitophagy in Rats.
    Title: Effect of Thyroxine on the Structural and Dynamic Features of Cardiac Mitochondria and Mitophagy in Rats.
  3. The pro-tumorigenic activity of p38gamma overexpression in nasopharyngeal carcinoma.
    Title: The pro-tumorigenic activity of p38γ overexpression in nasopharyngeal carcinoma.
  4. p38gamma and p38delta regulate postnatal cardiac metabolism through glycogen synthase 1.
    Title: p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1.
  5. In mouse hepatocytes, p38gamma induces proliferation after partial hepatectomy by promoting the phosphorylation of retinoblastoma tumour suppressor protein at known CDK target residues. Lack of p38gamma or treatment with the p38gamma inhibitor pirfenidone protects against the chemically induced formation of liver tumours.
    Title: p38γ is essential for cell cycle progression and liver tumorigenesis.
  6. Mitogen-activated protein kinases p38gamma/p38delta deficiency protects against Candida albicans infection by increasing reactive oxygen species and iNOS enzyme production and thus the antifungal capacity of neutrophils and macrophages.
    Title: Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity.
  7. p38gamma mitogen-activated protein kinase mediates inflammatory signaling to promote colon tumorigenesis
    Title: p38γ MAPK is required for inflammation-associated colon tumorigenesis.
  8. p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration and provide a potential target for NAFLD therapy
    Title: p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration.
  9. p38gamma and p38delta control heart growth by modulating mTOR pathway through DEPTOR phosphorylation and subsequent degradation.
    Title: p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation.
  10. Findings provide genetic evidence that p38gamma and p38delta have essential roles in skin tumour development.
    Title: Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase 12
Names
ERK-6
MAP kinase 12
MAP kinase p38 gamma
MAPK 12
extracellular signal-regulated kinase 6
mitogen-activated protein kinase p38 gamma
stress-activated protein kinase 3
NP_001389948.1
NP_001389949.1
NP_001389950.1
NP_001389951.1
NP_038899.1
XP_006521121.1
XP_006521122.1
XP_006521124.1
XP_036015349.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403019.1 → NP_001389948.1  mitogen-activated protein kinase 12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113069

  2. NM_001403020.1 → NP_001389949.1  mitogen-activated protein kinase 12 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113069

  3. NM_001403021.1 → NP_001389950.1  mitogen-activated protein kinase 12 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113069

  4. NM_001403022.1 → NP_001389951.1  mitogen-activated protein kinase 12 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC113069

  5. NM_013871.4 → NP_038899.1  mitogen-activated protein kinase 12 isoform 1

    See identical proteins and their annotated locations for NP_038899.1

    Status: VALIDATED

    Source sequence(s)
    AC113069
    Consensus CDS
    CCDS27740.1
    UniProtKB/Swiss-Prot
    O08911, Q9D0M4
    Related
    ENSMUSP00000086207.7, ENSMUST00000088827.8
    Conserved Domains (1) summary
    cd07880
    Location:11 → 353
    STKc_p38gamma; Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    89014787..89025270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159456.1 → XP_036015349.1  mitogen-activated protein kinase 12 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:11 → 366
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006521059.5 → XP_006521122.1  mitogen-activated protein kinase 12 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:11 → 360
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006521058.5 → XP_006521121.1  mitogen-activated protein kinase 12 isoform X1

    Conserved Domains (1) summary
    cd07880
    Location:11 → 376
    STKc_p38gamma; Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12)

  4. XM_006521061.5 → XP_006521124.1  mitogen-activated protein kinase 12 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:1 → 195
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08911.1 GenPept UniProtKB/Swiss-Prot:O08911

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