Echdc2 enoyl CoA hydratase domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Echdc2provided by RGD
Official Full Name: enoyl CoA hydratase domain containing 2provided by RGD
Primary source: RGD:1308525
See related: Ensembl:ENSRNOG00000029333 AllianceGenome:RGD:1308525
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308525
Summary: Predicted to enable enoyl-CoA hydratase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in mitochondrion. Orthologous to human ECHDC2 (enoyl-CoA hydratase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 186.3), Kidney (RPKM 133.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q34

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (128144241..128163611)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (122915874..122934860)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (127770570..127789568)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: enoyl-CoA hydratase domain-containing protein 2, mitochondrial

Names: enoyl Coenzyme A hydratase domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106675.1 → NP_001100145.1 enoyl-CoA hydratase domain-containing protein 2, mitochondrial

See identical proteins and their annotated locations for NP_001100145.1

Status: PROVISIONAL

Source sequence(s)

CH474008

UniProtKB/TrEMBL

A0A8I5ZUZ9, A6JYU2, D3ZIL6

Related

ENSRNOP00000049726.3, ENSRNOT00000047653.4

Conserved Domains (1) summary

cl23717
Location:42 → 296

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

128144241..128163611

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287394.1 → XP_063143464.1 enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I5ZV01
XM_063287395.1 → XP_063143465.1 enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I5ZV01
XM_039109577.2 → XP_038965505.1 enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A8I5ZUZ9

Conserved Domains (1) summary

cl23717
Location:45 → 244

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
XM_006238507.3 → XP_006238569.1 enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X3

See identical proteins and their annotated locations for XP_006238569.1

UniProtKB/TrEMBL

A6JYU3

Conserved Domains (1) summary

cl23717
Location:1 → 191

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...