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Pakap paralemmin A kinase anchor protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 298024, updated on 13-Apr-2024

Summary

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Official Symbol
Pakapprovided by RGD
Official Full Name
paralemmin A kinase anchor proteinprovided by RGD
Primary source
RGD:1305135
See related
Ensembl:ENSRNOG00000011504 AllianceGenome:RGD:1305135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Akap2; Palm2; AKAP-2
Summary
Enables protein domain specific binding activity. Predicted to act upstream of or within actin filament organization; protein localization; and transmembrane receptor protein serine/threonine kinase signaling pathway. Part of protein-containing complex. Orthologous to human PALM2AKAP2 (PALM2 and AKAP2 fusion). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 657.0), Kidney (RPKM 591.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q24
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (76976906..77443656)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (72536986..72648524)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (74874245..74985789)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100910620 Neighboring gene uncharacterized LOC120102883 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, pseudogene 8 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134486938 Neighboring gene similar to human chromosome 9 open reading frame 152 Neighboring gene thioredoxin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Kinderman FS, et al. Mol Cell, 2006 Nov 3. PMID 17081990, Free PMC Article
  2. Molecular characterization of a cDNA that encodes six isoforms of a novel murine A kinase anchor protein. Dong F, et al. J Biol Chem, 1998 Mar 13. PMID 9497389
  3. A-kinase anchoring proteins: from protein complexes to physiology and disease. Carnegie GK, et al. IUBMB Life, 2009 Apr. PMID 19319965, Free PMC Article
  4. Localized effects of cAMP mediated by distinct routes of protein kinase A. Taskén K, et al. Physiol Rev, 2004 Jan. PMID 14715913
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase A binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
A-kinase anchor protein 2
Names
A kinase (PRKA) anchor protein 2
A-kinase anchoring protein 2
paralemmin 2
paralemmin-2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011974.2 → NP_001011974.2  A-kinase anchor protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q5U301
    Related
    ENSRNOP00000092250.1, ENSRNOT00000117085.1
    Conserved Domains (2) summary
    PHA03247
    Location:613 → 810
    PHA03247; large tegument protein UL36; Provisional
    pfam15304
    Location:721 → 862
    AKAP2_C; A-kinase anchor protein 2 C-terminus

  2. NM_001305995.1 → NP_001292924.1  A-kinase anchor protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D4A4D8

  3. NM_001309260.1 → NP_001296189.1  A-kinase anchor protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001296189.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q5U301
    UniProtKB/TrEMBL
    A0A8I6A5A3
    Related
    ENSRNOP00000087137.1, ENSRNOT00000097436.1
    Conserved Domains (1) summary
    pfam15304
    Location:721 → 875
    AKAP2_C; A-kinase anchor protein 2 C-terminus

  4. NM_001425400.1 → NP_001412329.1  A-kinase anchor protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    76976906..77443656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287310.1 → XP_063143380.1  A-kinase anchor protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y1X4

  2. XM_063287308.1 → XP_063143378.1  A-kinase anchor protein 2 isoform X1

  3. XM_063287309.1 → XP_063143379.1  A-kinase anchor protein 2 isoform X2

  4. XM_063287311.1 → XP_063143381.1  A-kinase anchor protein 2 isoform X4

  5. XM_063287312.1 → XP_063143382.1  A-kinase anchor protein 2 isoform X5

  6. XM_063287313.1 → XP_063143383.1  A-kinase anchor protein 2 isoform X6

  7. XM_063287314.1 → XP_063143384.1  A-kinase anchor protein 2 isoform X7

  8. XM_006238186.4 → XP_006238248.1  A-kinase anchor protein 2 isoform X11

    See identical proteins and their annotated locations for XP_006238248.1

    UniProtKB/Swiss-Prot
    Q5U301
    UniProtKB/TrEMBL
    A0A8I6A5A3
    Conserved Domains (1) summary
    pfam15304
    Location:721 → 875
    AKAP2_C; A-kinase anchor protein 2 C-terminus

  9. XM_063287318.1 → XP_063143388.1  A-kinase anchor protein 2 isoform X12

  10. XM_063287321.1 → XP_063143391.1  A-kinase anchor protein 2 isoform X15

  11. XM_063287315.1 → XP_063143385.1  A-kinase anchor protein 2 isoform X8

  12. XM_063287317.1 → XP_063143387.1  A-kinase anchor protein 2 isoform X10

    UniProtKB/TrEMBL
    A0A8I6ADB4

  13. XM_063287320.1 → XP_063143390.1  A-kinase anchor protein 2 isoform X14

  14. XM_063287316.1 → XP_063143386.1  A-kinase anchor protein 2 isoform X9

  15. XM_063287319.1 → XP_063143389.1  A-kinase anchor protein 2 isoform X13

  16. XM_006238185.5 → XP_006238247.1  A-kinase anchor protein 2 isoform X11

    See identical proteins and their annotated locations for XP_006238247.1

    UniProtKB/Swiss-Prot
    Q5U301
    UniProtKB/TrEMBL
    A0A8I6A5A3
    Conserved Domains (1) summary
    pfam15304
    Location:721 → 875
    AKAP2_C; A-kinase anchor protein 2 C-terminus

  17. XM_039109444.2 → XP_038965372.1  A-kinase anchor protein 2 isoform X12

    UniProtKB/Swiss-Prot
    Q5U301
    Conserved Domains (2) summary
    PHA03247
    Location:613 → 810
    PHA03247; large tegument protein UL36; Provisional
    pfam15304
    Location:721 → 862
    AKAP2_C; A-kinase anchor protein 2 C-terminus

  18. XM_039109446.2 → XP_038965374.1  A-kinase anchor protein 2 isoform X15

    UniProtKB/TrEMBL
    F1LPQ9
    Conserved Domains (1) summary
    COG3611
    Location:201 → 272
    DnaB; Replication initiation and membrane attachment protein DnaB [Replication, recombination and repair]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U301.1 GenPept UniProtKB/Swiss-Prot:Q5U301

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