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Gpr63 G protein-coupled receptor 63 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297952, updated on 3-Apr-2024

Summary

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Official Symbol
Gpr63provided by RGD
Official Full Name
G protein-coupled receptor 63provided by RGD
Primary source
RGD:1306460
See related
Ensembl:ENSRNOG00000007675 AllianceGenome:RGD:1306460
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of receptor complex. Orthologous to human GPR63 (G protein-coupled receptor 63). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 37.2), Uterus (RPKM 18.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (43469112..43523840)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (38672548..38727224)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (39258438..39374187)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4 Neighboring gene 60S ribosomal protein L39-like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene four and a half LIM domains 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Ghai R, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382219, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106640.2 → NP_001100110.1  probable G-protein coupled receptor 63

    See identical proteins and their annotated locations for NP_001100110.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6IIH2, D3ZNT8
    Related
    ENSRNOP00000010081.2, ENSRNOT00000010081.4
    Conserved Domains (1) summary
    cd15404
    Location:88 → 388
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    43469112..43523840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237949.5 → XP_006238011.1  probable G-protein coupled receptor 63 isoform X1

    See identical proteins and their annotated locations for XP_006238011.1

    UniProtKB/TrEMBL
    A6IIH2, D3ZNT8
    Related
    ENSRNOP00000094571.1
    Conserved Domains (1) summary
    cd15404
    Location:88 → 388
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_039109425.2 → XP_038965353.1  probable G-protein coupled receptor 63 isoform X1

    UniProtKB/TrEMBL
    A6IIH2, D3ZNT8
    Related
    ENSRNOP00000095054.1
    Conserved Domains (1) summary
    cd15404
    Location:88 → 388
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_039109424.2 → XP_038965352.1  probable G-protein coupled receptor 63 isoform X1

    UniProtKB/TrEMBL
    A6IIH2, D3ZNT8
    Related
    ENSRNOP00000091034.1
    Conserved Domains (1) summary
    cd15404
    Location:88 → 388
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_063287298.1 → XP_063143368.1  probable G-protein coupled receptor 63 isoform X1

    UniProtKB/TrEMBL
    A6IIH2, D3ZNT8

  5. XM_017593232.3 → XP_017448721.1  probable G-protein coupled receptor 63 isoform X1

    UniProtKB/TrEMBL
    A6IIH2, D3ZNT8
    Conserved Domains (1) summary
    cd15404
    Location:88 → 388
    7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version

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