Atp6v1e1 ATPase H+ transporting V1 subunit E1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp6v1e1provided by RGD
Official Full Name: ATPase H+ transporting V1 subunit E1provided by RGD
Primary source: RGD:735157
See related: Ensembl:ENSRNOG00000011905 AllianceGenome:RGD:735157
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P31; Vma4; Atp6e; Atp6e2
Summary: Predicted to enable ATPase binding activity and proton-transporting ATPase activity, rotational mechanism. Predicted to act upstream of or within proton transmembrane transport. Part of vacuolar proton-transporting V-type ATPase, V1 domain. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIC. Orthologous to human ATP6V1E1 (ATPase H+ transporting V1 subunit E1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 1171.2), Adrenal (RPKM 1013.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (155694534..155716660, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (154022358..154044486, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (153351434..153373558, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Apical localization of V-ATPase in cholangiocytes may indicate its involvement in pH regulation and/or HCO (3)(-) salvage to compensate for NHE3 down-regulation in BDL.
Title: Differential regulation of vacuolar H+ -ATPase and Na+/H+ exchanger 3 in rat cholangiocytes after bile duct ligation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA818483 (e-PCR)
- UniSTS:249716

Atp6v1e1 (e-PCR), detects polymorphism
- UniSTS:527262

Atp6v1e1 (e-PCR), detects polymorphism
- UniSTS:527054

RH79089 (e-PCR)
- UniSTS:15604

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables proton-transporting ATPase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
enables proton-transporting ATPase activity, rotational mechanism	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle lumen acidification	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extrinsic component of synaptic vesicle membrane	EXP Inferred from Experiment more info	PubMed
is_active_in extrinsic component of synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of proton-transporting two-sector ATPase complex, catalytic domain	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V1 domain	IDA Inferred from Direct Assay more info	PubMed
part_of vacuolar proton-transporting V-type ATPase, V1 domain	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V1 domain	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: V-type proton ATPase subunit E 1

Names: ATPase, H+ transporting, V1 subunit E; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E; ATPase, H+ transporting, lysosomal V1 subunit E1; V-ATPase subunit E 1; VATPase, H+ transporting, lysosomal V1 subunit E1; vacuolar H(+)-ATPase, E subunit; vacuolar H+ ATPase E1; vacuolar proton pump subunit E 1

NP_942040.2

EC 7.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198745.3 → NP_942040.2 V-type proton ATPase subunit E 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q6PCU2

UniProtKB/TrEMBL

A6ILB2, G3V7L8

Related

ENSRNOP00000016495.4, ENSRNOT00000016495.7

Conserved Domains (1) summary

pfam01991
Location:18 → 216

vATP-synt_E; ATP synthase (E/31 kDa) subunit