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Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29719, updated on 11-Apr-2024

Summary

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Official Symbol
Kcnj16provided by RGD
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 16provided by RGD
Primary source
RGD:61824
See related
Ensembl:ENSRNOG00000004713 AllianceGenome:RGD:61824
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kir5.1
Summary
Predicted to enable inward rectifier potassium channel activity. Involved in potassium ion transport; regulation of pH; and response to carbon dioxide. Located in basolateral plasma membrane. Used to study hypokalemia and metabolic acidosis. Orthologous to human KCNJ16 (potassium inwardly rectifying channel subfamily J member 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 1043.6) See more
Orthologs
human mouse all
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Genomic context

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Location:
10q32.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (96489329..96520745)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (95990009..96021356)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (99330894..99391551)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551705 Neighboring gene uncharacterized LOC108352228 Neighboring gene uncharacterized LOC120095205 Neighboring gene uncharacterized LOC120095206 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat. Manis AD, et al. JCI Insight, 2021 Jan 11. PMID 33232300, Free PMC Article
  2. Relationship between the renin-angiotensin-aldosterone system and renal Kir5.1 channels. Manis AD, et al. Clin Sci (Lond), 2019 Dec 20. PMID 31799617, Free PMC Article
  3. Genetic mutation of Kcnj16 identifies Kir5.1-containing channels as key regulators of acute and chronic pH homeostasis. Puissant MM, et al. FASEB J, 2019 Apr. PMID 30605394, Free PMC Article
  4. Essential role of Kir5.1 channels in renal salt handling and blood pressure control. Palygin O, et al. JCI Insight, 2017 Sep 21. PMID 28931751, Free PMC Article
  5. Expression of an inwardly rectifying K+ channel, Kir5.1, in specific types of fibrocytes in the cochlear lateral wall suggests its functional importance in the establishment of endocochlear potential. Hibino H, et al. Eur J Neurosci, 2004 Jan. PMID 14750965

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Repeated seizures lead to progressive ventilatory dysfunction in SS[Kcnj16-/-] rats.
    Title: Repeated seizures lead to progressive ventilatory dysfunction in SS(Kcnj16-/-) rats.
  2. Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat.
    Title: Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat.
  3. Knockout of Kcnj16 markedly altered RAAS regulation and function, suggesting Kir5.1 as a key regulator of the renin-angiotensin-aldosterone system , particularly when exposed to changes in dietary sodium and potassium content.
    Title: Relationship between the renin-angiotensin-aldosterone system and renal Kir5.1 channels.
  4. results demonstrate that Kir5.1 channels are key regulators of renal salt handling in salt-sensitive hypertension
    Title: Essential role of Kir5.1 channels in renal salt handling and blood pressure control.
  5. Heteromeric Kir4.1-Kir5.1 channels confer pH sensitivity to retrotrapezoid nucleus astrocytes.
    Title: Astrocytes in the retrotrapezoid nucleus sense H+ by inhibition of a Kir4.1-Kir5.1-like current and may contribute to chemoreception by a purinergic mechanism.
  6. examined the heteromeric assembly of Kir5.1 with other Kir subunits and have shown that this subunit exhibits a highly selective interaction with members of the Kir4.0 subfamily and does not physically associate with other Kir subunits
    Title: Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels.
  7. data suggest the signals on the COOH terminus of Kir4.1 potassium channel determine the intracellular localization of Kir5.1 potassium channel/Kir4.1 heteromer in distal tubules
    Title: PDZ binding motif-dependent localization of K+ channel on the basolateral side in distal tubules.
  8. Specific immunoreactivity for Kir5.1 was detected in fibrocytes of the cochlear spiral ligament and spiral limbus, all of which are directly involved in K+ circulation.
    Title: Expression of an inwardly rectifying K+ channel, Kir5.1, in specific types of fibrocytes in the cochlear lateral wall suggests its functional importance in the establishment of endocochlear potential.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to carbon dioxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inward rectifier potassium channel 16
Names
BIR9
inward rectifier K(+) channel Kir5.1
potassium channel, inwardly rectifying subfamily J member 16
potassium voltage-gated channel subfamily J member 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053314.3 → NP_445766.2  inward rectifier potassium channel 16

    See identical proteins and their annotated locations for NP_445766.2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P52191, Q9JI87
    UniProtKB/TrEMBL
    A0A8I5ZPC6, Q68G21
    Conserved Domains (2) summary
    pfam01007
    Location:37 → 173
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:182 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    96489329..96520745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247570.4 → XP_006247632.1  inward rectifier potassium channel 16 isoform X1

    See identical proteins and their annotated locations for XP_006247632.1

    UniProtKB/Swiss-Prot
    P52191, Q9JI87
    UniProtKB/TrEMBL
    A0A8I5ZPC6, Q68G21
    Related
    ENSRNOP00000089334.1
    Conserved Domains (2) summary
    pfam01007
    Location:37 → 173
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:182 → 349
    IRK_C; Inward rectifier potassium channel C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52191.2 GenPept UniProtKB/Swiss-Prot:P52191

Gene LinkOut

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