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Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29713, updated on 3-Apr-2024

Summary

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Official Symbol
Kcnj5provided by RGD
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 5provided by RGD
Primary source
RGD:61971
See related
Ensembl:ENSRNOG00000033796 AllianceGenome:RGD:61971
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable inward rectifier potassium channel activity and voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization. Predicted to be involved in cardiac conduction; potassium ion import across plasma membrane; and regulation of ion transmembrane transport. Located in T-tubule and external side of plasma membrane. Human ortholog(s) of this gene implicated in atrial fibrillation; long QT syndrome 13; and primary hyperaldosteronism. Orthologous to human KCNJ5 (potassium inwardly rectifying channel subfamily J member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 183.1), Lung (RPKM 29.3) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (38981598..39011197, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (30724923..30753083, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (33435493..33463410, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480155 Neighboring gene Rho GTPase activating protein 32 Neighboring gene ribosomal protein L35 like 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 1 Neighboring gene Fli-1 proto-oncogene, ETS transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Constitutively Active Acetylcholine-Dependent Potassium Current Increases Atrial Defibrillation Threshold by Favoring Post-Shock Re-Initiation. Bingen BO, et al. Sci Rep, 2015 Oct 21. PMID 26487066, Free PMC Article
  2. Effect of small interference RNA on the acetylcholine-sensitive potassium channel in H9c2 cells. He F, et al. Ann Clin Lab Sci, 2015 Winter. PMID 25696012
  3. G-protein-gated inwardly rectifying K+ channel 4 (GIRK4) immunoreactivity in chemically defined neurons of the hypothalamic arcuate nucleus that control body weight. Kloukina V, et al. J Chem Neuroanat, 2012 May. PMID 22465809
  4. The KATP channel is a molecular sensor of atrophy in skeletal muscle. Tricarico D, et al. J Physiol, 2010 Mar 1. PMID 20064856, Free PMC Article
  5. Hydrogen sulfide opens the KATP channel on rat atrial and ventricular myocytes. Zhong GZ, et al. Cardiology, 2010. PMID 19940474

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Blocking IK,ACh-c by tertiapin significantly decreased DFT, which correlated with a significant increase in wavelength during reentry. Genetic knockdown experiments with Kcnj5-specific shRNA to modulate IK,ACh-c, yielded similar results
    Title: Constitutively Active Acetylcholine-Dependent Potassium Current Increases Atrial Defibrillation Threshold by Favoring Post-Shock Re-Initiation.
  2. The KCNJ5 gene and Kir3.4 protein were measured, and acetylcholine-sensitive potassium channel currents were recorded by patch-clamp.
    Title: Effect of small interference RNA on the acetylcholine-sensitive potassium channel in H9c2 cells.
  3. localized in intercalated discs in rat ventricle, whereas it was expressed in intercalated discs and outer sarcolemmas in rat atrium
    Title: G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization.
  4. the GIRK4 channel protein plays a role in regulating membrane excitability in chemically defined neurons of the arcuate nucleus that control body weight
    Title: G-protein-gated inwardly rectifying K+ channel 4 (GIRK4) immunoreactivity in chemically defined neurons of the hypothalamic arcuate nucleus that control body weight.
  5. Estradiol regulates dopamine-activataed GIRK channel activity in pituitary lactotrophs, regulating prolactin release during the estrous cycle.
    Title: Estrogen regulation of the dopamine-activated GIRK channel in pituitary lactotrophs: implications for regulation of prolactin release during the estrous cycle.
  6. All these findings suggest a new role for the K(ATP) channel as a molecular sensor of atrophy.
    Title: The KATP channel is a molecular sensor of atrophy in skeletal muscle.
  7. hydrogen sulfide-induced increase in I(K,ATP) on both atrial and ventricular myocytes was concentration dependent
    Title: Hydrogen sulfide opens the KATP channel on rat atrial and ventricular myocytes.
  8. Galpha(q) interacted with N termini of Kir3.1, Kir3.2, and Kir3.4. However, Galpha(q) did not interact with the C terminus of any Kir3
    Title: Interaction of Galphaq and Kir3, G protein-coupled inwardly rectifying potassium channels.
  9. The point mutation L337R in the GIRK4 C terminus decreased the association between the N and C termini.
    Title: Mutation of critical GIRK subunit residues disrupts N- and C-termini association and channel function.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93525

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-protein activated inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in membrane repolarization during atrial cardiac muscle cell action potential IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane repolarization during atrial cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of heart rate by cardiac conduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in T-tubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
G protein-activated inward rectifier potassium channel 4
Names
CIR
GIRK-4
GIRK4
KATP-1
cardiac inward rectifier
heart KATP channel
inward rectifier K(+) channel Kir3.4
potassium channel, inwardly rectifying subfamily J member 5
potassium voltage-gated channel subfamily J member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017297.2 → NP_058993.1  G protein-activated inward rectifier potassium channel 4

    See identical proteins and their annotated locations for NP_058993.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087022
    UniProtKB/Swiss-Prot
    P48548
    Related
    ENSRNOP00000048134.5, ENSRNOT00000041038.6
    Conserved Domains (2) summary
    pfam01007
    Location:54 → 193
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:200 → 371
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    38981598..39011197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080975.2 → XP_038936903.1  G protein-activated inward rectifier potassium channel 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G4T8
    Related
    ENSRNOP00000079101.1
    Conserved Domains (2) summary
    pfam01007
    Location:73 → 212
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:219 → 390
    IRK_C; Inward rectifier potassium channel C-terminal domain

  2. XM_039080976.2 → XP_038936904.1  G protein-activated inward rectifier potassium channel 4 isoform X3

    UniProtKB/Swiss-Prot
    P48548
    Conserved Domains (2) summary
    pfam01007
    Location:54 → 193
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:200 → 371
    IRK_C; Inward rectifier potassium channel C-terminal domain

  3. XM_039080977.2 → XP_038936905.1  G protein-activated inward rectifier potassium channel 4 isoform X3

    UniProtKB/Swiss-Prot
    P48548
    Conserved Domains (2) summary
    pfam01007
    Location:54 → 193
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:200 → 371
    IRK_C; Inward rectifier potassium channel C-terminal domain

  4. XM_063265036.1 → XP_063121106.1  G protein-activated inward rectifier potassium channel 4 isoform X3

    UniProtKB/Swiss-Prot
    P48548

  5. XM_063265035.1 → XP_063121105.1  G protein-activated inward rectifier potassium channel 4 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48548.2 GenPept UniProtKB/Swiss-Prot:P48548

Gene LinkOut

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