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Atp6v0a4 ATPase H+ transporting V0 subunit a4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296981, updated on 13-Apr-2024

Summary

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Official Symbol
Atp6v0a4provided by RGD
Official Full Name
ATPase H+ transporting V0 subunit a4provided by RGD
Primary source
RGD:1305055
See related
Ensembl:ENSRNOG00000013428 AllianceGenome:RGD:1305055
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATPase binding activity. Predicted to be involved in several processes, including excretion; sensory perception of sound; and vacuolar acidification. Predicted to act upstream of or within proton transmembrane transport. Located in apical plasma membrane. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human ATP6V0A4 (ATPase H+ transporting V0 subunit a4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 558.7) and Brain (RPKM 31.5) See more
Orthologs
human mouse all
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Genomic context

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Location:
4q23
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (67727145..67809092, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (66760163..66842126, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (65736585..65821916, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene high-mobility group box 1, pseudogene 18 Neighboring gene tripartite motif-containing 24 Neighboring gene SVOP like Neighboring gene uncharacterized LOC134486756 Neighboring gene transmembrane protein 213 Neighboring gene KIAA1549 homolog Neighboring gene zinc finger CCCH-type containing, antiviral 1 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Localization and regulation of the ATP6V0A4 (a4) vacuolar H+-ATPase subunit defective in an inherited form of distal renal tubular acidosis. Stehberger PA, et al. J Am Soc Nephrol, 2003 Dec. PMID 14638902
  2. Molecular cloning and characterization of Atp6n1b: a novel fourth murine vacuolar H+-ATPase a-subunit gene. Smith AN, et al. J Biol Chem, 2001 Nov 9. PMID 11495928
  3. Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump 116-kD subunit, cause recessive distal renal tubular acidosis with preserved hearing. Smith AN, et al. Nat Genet, 2000 Sep. PMID 10973252
  4. Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rats. Petrovic S, et al. Am J Physiol Renal Physiol, 2006 May. PMID 16352747
  5. Novel ATP6V1B1 and ATP6V0A4 mutations in autosomal recessive distal renal tubular acidosis with new evidence for hearing loss. Stover EH, et al. J Med Genet, 2002 Nov. PMID 12414817, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in ossification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proton transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in proton transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of pH ISO
Inferred from Sequence Orthology
more info
  
involved_in renal tubular secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle lumen acidification ISO
Inferred from Sequence Orthology
more info
  
involved_in vacuolar acidification IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of vacuolar proton-transporting V-type ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of vacuolar proton-transporting V-type ATPase complex ISO
Inferred from Sequence Orthology
more info
  
part_of vacuolar proton-transporting V-type ATPase, V0 domain IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
V-type proton ATPase 116 kDa subunit a 4
Names
ATPase, H+ transporting, lysosomal V0 subunit A
ATPase, H+ transporting, lysosomal V0 subunit A4
V-type proton ATPase 116 kDa subunit a
NP_001402767.1
XP_063141818.1
XP_063141819.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415838.1 → NP_001402767.1  V-type proton ATPase 116 kDa subunit a 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    Related
    ENSRNOP00000061018.1, ENSRNOT00000064201.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    67727145..67809092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285748.1 → XP_063141818.1  V-type proton ATPase 116 kDa subunit a 4 isoform X1

  2. XM_063285749.1 → XP_063141819.1  V-type proton ATPase 116 kDa subunit a 4 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106591.1: Suppressed sequence

    Description
    NM_001106591.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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