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Akr1b10 aldo-keto reductase family 1 member B10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 296972, updated on 11-Apr-2024

Summary

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Symbol
Akr1b10provided by RGD
Full Name
aldo-keto reductase family 1 member B10provided by RGD
Primary source
RGD:1308277
See related
Ensembl:ENSRNOG00000009734 AllianceGenome:RGD:1308277
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables NADP binding activity; alcohol dehydrogenase (NADP+) activity; and retinal binding activity. Involved in polyol metabolic process; retinal metabolic process; and retinol metabolic process. Located in cytosol. Orthologous to human AKR1B10 (aldo-keto reductase family 1 member B10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 1546.2), Kidney (RPKM 276.7) and 3 other tissues See more
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Genomic context

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Location:
4q22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (64005632..64027860)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (63038459..63060336)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (61813265..61830371)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member B8 Neighboring gene uncharacterized LOC134486751 Neighboring gene myosin light chain 6, pseudogene 4 Neighboring gene aldo-keto reductase family 1, member B7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Properties and tissue distribution of a novel aldo-keto reductase encoding in a rat gene (Akr1b10). Endo S, et al. Arch Biochem Biophys, 2010 Nov 15. PMID 20709016
  2. Aldo-keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels. Zhong L, et al. Biochem Biophys Res Commun, 2009 Sep 18. PMID 19563777, Free PMC Article
  3. Role of human aldo-keto-reductase AKR1B10 in the protection against toxic aldehydes. Martin HJ, et al. Chem Biol Interact, 2009 Mar 16. PMID 19013440
  4. Aldo-keto reductases and bioactivation/detoxication. Jin Y, et al. Annu Rev Pharmacol Toxicol, 2007. PMID 16970545
  5. Meta-analysis of three diabetes population studies: association of inactive ALDH2 genotype with maternal inheritance of diabetes. Murata C, et al. Diabetes Res Clin Pract, 2004 Dec. PMID 15563966

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results demonstrate that Akr7a3 mRNA and protein levels are consistently co-expressed along with Akr1b10, in both experimental rat liver carcinogenesis and some human hepatocellular carcinoma samples.
    Title: Aldo-Keto Reductases as Early Biomarkers of Hepatocellular Carcinoma: A Comparison Between Animal Models and Human HCC.
  2. Properties and tissue distribution of a novel carbonyl reductase (NADPH) encoding in a rat gene are reported.
    Title: Properties and tissue distribution of a novel aldo-keto reductase encoding in a rat gene (Akr1b10).
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NADP+ binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADPH binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables alcohol dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables aldose reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables all-trans-retinol dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables all-trans-retinol dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables geranylgeranyl reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables indanol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables retinal binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables retinal dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular detoxification of aldehyde ISO
Inferred from Sequence Orthology
more info
  
involved_in daunorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in doxorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in farnesol catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in polyol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retinal metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retinoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aldo-keto reductase family 1 member B10
Names
aldo-keto reductase family 1, member B10 (aldose reductase)
aldose reductase-related protein 1-like
NP_001013102.1
XP_038963219.1
XP_038963220.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013084.1 → NP_001013102.1  aldo-keto reductase family 1 member B10

    See identical proteins and their annotated locations for NP_001013102.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079133
    UniProtKB/TrEMBL
    A0A8I5ZN93, M0R8B8, Q6AY99
    Related
    ENSRNOP00000079554.1, ENSRNOT00000114062.1
    Conserved Domains (1) summary
    cd19107
    Location:10 → 316
    AKR_AKR1B1-19; AKR1B family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    64005632..64027860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107291.2 → XP_038963219.1  aldo-keto reductase family 1 member B10 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZN93, M0R8B8, Q6AY99
    Related
    ENSRNOP00000065713.1
    Conserved Domains (1) summary
    cd19107
    Location:10 → 316
    AKR_AKR1B1-19; AKR1B family of aldo-keto reductase (AKR)

  2. XM_039107292.2 → XP_038963220.1  aldo-keto reductase family 1 member B10 isoform X2

    UniProtKB/TrEMBL
    A6IEM0
    Conserved Domains (1) summary
    cl00470
    Location:1 → 172
    AKR_SF; Aldo-keto reductase (AKR) superfamily

RNA

  1. XR_001837481.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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