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Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide [ Rattus norvegicus (Norway rat) ]

Gene ID: 29646, updated on 4-Jan-2025

Summary

Official Symbol
Adh4provided by RGD
Official Full Name
alcohol dehydrogenase 4 (class II), pi polypeptideprovided by RGD
Primary source
RGD:71028
See related
EnsemblRapid:ENSRNOG00000046357 AllianceGenome:RGD:71028
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ADH-1; Ac1002
Summary
Predicted to enable several functions, including NADPH:quinone reductase activity; alcohol dehydrogenase [NAD(P)+] activity; and retinoid binding activity. Involved in ovulation cycle and response to ethanol. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human ADH4 (alcohol dehydrogenase 4 (class II), pi polypeptide). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 190.0) See more
Orthologs
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Genomic context

See Adh4 in Genome Data Viewer
Location:
2q44
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (229622092..229640120)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (226948717..226966747)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (243702035..243720063)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene alcohol dehydrogenase 6 (class V) Neighboring gene uncharacterized LOC134485688 Neighboring gene alcohol dehydrogenase 5 (class III), chi polypeptide Neighboring gene methionyl aminopeptidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Potential readthrough

Included gene: Adh5

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD binding  
enables NADPH:quinone reductase activity  
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity  
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity  
enables alcohol dehydrogenase (NAD+) activity  
enables alcohol dehydrogenase (NAD+) activity  
enables alcohol dehydrogenase (NAD+) activity  
enables aldose reductase (NADPH) activity  
enables all-trans retinal binding  
enables all-trans-retinol dehydrogenase (NAD+) activity  
enables all-trans-retinol dehydrogenase (NAD+) activity  
enables benzaldehyde dehydrogenase (NAD+) activity  
enables oxidoreductase activity  
enables retinol binding  
enables zinc ion binding  
enables zinc ion binding  
enables zinc ion binding  
Process Evidence Code Pubs
acts_upstream_of_or_within alcohol catabolic process  
involved_in alcohol metabolic process  
acts_upstream_of_or_within aldehyde metabolic process  
involved_in aldehyde metabolic process  
acts_upstream_of_or_within ethanol metabolic process  
involved_in fatty acid omega-oxidation  
involved_in fatty acid omega-oxidation  
involved_in formaldehyde catabolic process  
involved_in formaldehyde catabolic process  
involved_in ovulation cycle PubMed 
acts_upstream_of_or_within quinone metabolic process  
involved_in response to ethanol PubMed 
involved_in retinoid metabolic process  
involved_in retinol metabolic process  
involved_in retinol metabolic process  
Component Evidence Code Pubs
located_in cytoplasm  
is_active_in cytosol  
located_in cytosol  
located_in nucleoplasm  

General protein information

Preferred Names
all-trans-retinol dehydrogenase [NAD(+)] ADH4
Names
ADH2
alcohol dehydrogenase 2
alcohol dehydrogenase 4-like
alcohol dehydrogenase II
alcohol dehydrogenase class II
class II alcohol dehydrogenase, pi subunit
NP_058966.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017270.2 → NP_058966.2  all-trans-retinol dehydrogenase [NAD(+)] ADH4

    See identical proteins and their annotated locations for NP_058966.2

    Status: PROVISIONAL

    Source sequence(s)
    BC127504
    UniProtKB/Swiss-Prot
    Q64563
    UniProtKB/TrEMBL
    A1L128
    Related
    ENSRNOP00000077866.1, ENSRNOT00000104576.2
    Conserved Domains (1) summary
    cd08299
    Location:3 → 377
    alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    229622092..229640120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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