F2rl2 coagulation factor II (thrombin) receptor-like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: F2rl2provided by RGD
Official Full Name: coagulation factor II (thrombin) receptor-like 2provided by RGD
Primary source: RGD:620871
See related: Ensembl:ENSRNOG00000018054 AllianceGenome:RGD:620871
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PAR3
Summary: Predicted to enable G protein-coupled receptor activity. Involved in response to wounding. Predicted to be located in apical plasma membrane. Predicted to be part of protein-containing complex. Predicted to be integral component of plasma membrane. Orthologous to human F2RL2 (coagulation factor II thrombin receptor like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 108.7), Liver (RPKM 40.5) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (28706766..28711808)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (26972054..26977098)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (26240385..26245533)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAR1 and PAR3 could be involved in thrombin-modulated initiation of post-ischemic inflammation and PAR4 may be associated with neuronal degeneration. (Protease-activated receptor 1, 3, 4)
Title: Focal ischemia induces expression of protease-activated receptor1 (PAR1) and PAR3 on microglia and enhances PAR4 labeling in the penumbra.
Par-3 mRNA is expressed in the developing rat eye and adult retina but shows a delayed upregulation after optic nerve crush compared to Par-1, Par-2, and Par-4.
Title: Protease-activated receptor subtype expression in developing eye and adult retina of the rat after optic nerve crush.
PAR 3 is regulated at the transcriptional level in a rat model of lipopolysaccharide induced acute lung injury and probably has a distinct role.
Title: Differential expression, time course and distribution of four PARs in rats with endotoxin-induced acute lung injury.
Expression of protease-activated receptor 3 does not change significantly in the hippocampus following severe ischemic insult.
Title: Increase of prothrombin-mRNA after global cerebral ischemia in rats, with constant expression of protease nexin-1 and protease-activated receptors.
Involvement of the thrombin receptors PAR-1, PAR-3, and PAR-4 in the pathophysiology of brain ischemia was suggested by decreased mRNA levels observed for PAR-1, -2, and -3, whereas PAR-4 levels were reduced only after 7 days
Title: Transient focal ischemia in rat brain differentially regulates mRNA expression of protease-activated receptors 1 to 4.

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General gene information

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Markers

F2rl2 (e-PCR), detects polymorphism
- UniSTS:536431

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables proteinase-activated receptor activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables thrombin-activated receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in ligand-gated ion channel signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ligand-gated ion channel signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in thrombin-activated receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proteinase-activated receptor 3

Names: PAR-3; coagulation factor II receptor-like 2; protease-activated receptor 3; thrombin receptor-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.