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Eif2s2 eukaryotic translation initiation factor 2 subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 296302, updated on 5-Mar-2024

Summary

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Official Symbol
Eif2s2provided by RGD
Official Full Name
eukaryotic translation initiation factor 2 subunit betaprovided by RGD
Primary source
RGD:735192
See related
Ensembl:ENSRNOG00000017447 AllianceGenome:RGD:735192
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mRNA binding activity; translation initiation factor activity; and translation initiation factor binding activity. Predicted to be involved in formation of cytoplasmic translation initiation complex and formation of translation preinitiation complex. Predicted to act upstream of or within in utero embryonic development; male germ cell proliferation; and male gonad development. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 2 complex. Orthologous to human EIF2S2 (eukaryotic translation initiation factor 2 subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 723.9), Testes (RPKM 497.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q41
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (163834846..163855733, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (143374652..143395460, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (150391455..150412179, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L38 like 6 Neighboring gene RALY heterogeneous nuclear ribonucleoprotein Neighboring gene Sec61 translocon subunit gamma, pseudogene 7 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene agouti signaling protein Neighboring gene transfer RNA alanine (anticodon AGC) 28

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Shape and location of eukaryotic initiation factor eIF-2 on the 40S ribosomal subunit of rat liver. Immunoelectron-microscopic and hydrodynamic investigations. Bommer UA, et al. Eur J Biochem, 1988 Mar 15. PMID 2450747
  2. Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice. Heaney JD, et al. Hum Mol Genet, 2009 Apr 15. PMID 19168544, Free PMC Article
  3. Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2. Ben-Asouli Y, et al. Nucleic Acids Res, 2000 Feb 15. PMID 10648795, Free PMC Article
  4. eIF2γ mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation. Borck G, et al. Mol Cell, 2012 Nov 30. PMID 23063529, Free PMC Article
  5. Modulation of protein translation by Nck-1. Kebache S, et al. Proc Natl Acad Sci U S A, 2002 Apr 16. PMID 11959995, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cytoplasmic translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within male germ cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within male gonad development ISO
Inferred from Sequence Orthology
more info
  
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation initiation factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 2 complex ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 2 subunit 2
Names
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199380.1 → NP_955412.1  eukaryotic translation initiation factor 2 subunit 2

    See identical proteins and their annotated locations for NP_955412.1

    Status: PROVISIONAL

    Source sequence(s)
    BC062402
    UniProtKB/TrEMBL
    A0A8I6A6W5, A6KI11, F7FE42, Q6P685
    Related
    ENSRNOP00000023786.4, ENSRNOT00000023786.6
    Conserved Domains (1) summary
    smart00653
    Location:199 → 308
    eIF2B_5; domain present in translation initiation factor eIF2B and eIF5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    163834846..163855733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283372.1 → XP_063139442.1  eukaryotic translation initiation factor 2 subunit 2 isoform X1

  2. XM_063283373.1 → XP_063139443.1  eukaryotic translation initiation factor 2 subunit 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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