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Gria4 glutamate ionotropic receptor AMPA type subunit 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29629, updated on 4-Jan-2025

Summary

Official Symbol
Gria4provided by RGD
Official Full Name
glutamate ionotropic receptor AMPA type subunit 4provided by RGD
Primary source
RGD:61863
See related
EnsemblRapid:ENSRNOG00000006957 AllianceGenome:RGD:61863
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GluA4; GluR4; GluR-D
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward (RPKM 345.6) See more
Orthologs
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Genomic context

See Gria4 in Genome Data Viewer
Location:
8q11
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (9845421..10320021, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (1562118..2035035, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (1548145..2045874, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 431 like, pseudogene 4 Neighboring gene Myb/SANT DNA binding domain containing 4 with coiled-coils Neighboring gene uncharacterized LOC120094073 Neighboring gene uncharacterized LOC134480139 Neighboring gene phosphoglycerate kinase 1, pseudogene 4 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 35

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables AMPA glutamate receptor activity  
enables AMPA glutamate receptor activity  
enables AMPA glutamate receptor activity PubMed 
enables AMPA glutamate receptor activity  
enables AMPA glutamate receptor activity PubMed 
enables glutamate-gated receptor activity PubMed 
enables identical protein binding PubMed 
enables ligand-gated monoatomic ion channel activity  
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
enables protein binding PubMed 
enables signaling receptor activity  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
Items 1 - 20 of 24
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex  
part_of AMPA glutamate receptor complex PubMed 
part_of AMPA glutamate receptor complex  
located_in dendrite PubMed 
located_in dendrite PubMed 
is_active_in dendritic spine  
located_in dendritic spine PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse  
part_of ionotropic glutamate receptor complex PubMed 
part_of kainate selective glutamate receptor complex PubMed 
located_in membrane  
located_in neuronal cell body PubMed 
located_in neuronal cell body  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in postsynaptic density PubMed 
is_active_in postsynaptic density membrane  
is_active_in postsynaptic density membrane PubMed 
located_in postsynaptic membrane  
is_active_in presynaptic active zone membrane PubMed 
located_in synapse PubMed 
located_in synapse  
located_in terminal bouton PubMed 
Items 1 - 20 of 24

General protein information

Preferred Names
glutamate receptor 4
Names
AMPA-selective glutamate receptor 4
glutamate receptor, ionotrophic, AMPA 4
glutamate receptor, ionotropic, AMPA 4
glutamate receptor, ionotropic, AMPA4 (alpha 4)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113184.1NP_001106655.1  glutamate receptor 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001106655.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate internal coding exon compared to transcript variant 1, and encodes an isoform (2, also known as flop isoform) that is the same length, but with a few amino acid differences compared to isoform 1. RNA editing (AGA->GGA) changes Arg765Gly.
    Source sequence(s)
    BC093608, BF390245, BF390683, BF413680, CB761818, CK598329, M36421, M85037
    UniProtKB/Swiss-Prot
    P19493, Q64241
    UniProtKB/TrEMBL
    A6KQJ7, G3V6W1
    Related
    ENSRNOP00000009542.6, ENSRNOT00000009542.7
    Conserved Domains (4) summary
    cd06388
    Location:28398
    PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
    cd13727
    Location:414795
    PBP2_iGluR_AMPA_GluR4; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR4 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:546825
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:39380
    ANF_receptor; Receptor family ligand binding region
  2. NM_001113185.1NP_001106656.1  glutamate receptor 4 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001106656.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is missing several coding exons at the 3' end, and contains a novel 3' terminal exon compared to transcript variant 1. This results in a shorter isoform (3) with a different C-terminus compared to isoform 1.
    Source sequence(s)
    BC093608, CB761818, DV726151
    UniProtKB/TrEMBL
    A0A8I5ZUN6, Q566D4
    Related
    ENSRNOP00000068876.1, ENSRNOT00000078765.3
    Conserved Domains (2) summary
    cd06388
    Location:28398
    PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
    pfam01094
    Location:39380
    ANF_receptor; Receptor family ligand binding region
  3. NM_017263.2NP_058959.2  glutamate receptor 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_058959.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1 (also known as flip isoform). RNA editing (AGA->GGA) changes Arg765Gly.
    Source sequence(s)
    BC093608, BF390245, BF390683, BF413680, CB761818, M38063, M85037
    UniProtKB/Swiss-Prot
    P19493, Q64241
    UniProtKB/TrEMBL
    A0A0G2JU28, A6KQJ6
    Related
    ENSRNOP00000068940.1, ENSRNOT00000081171.3
    Conserved Domains (4) summary
    cd06388
    Location:28398
    PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
    cd13727
    Location:414795
    PBP2_iGluR_AMPA_GluR4; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR4 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:546825
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:39380
    ANF_receptor; Receptor family ligand binding region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    9845421..10320021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265032.1XP_063121102.1  glutamate receptor 4 isoform X4

    UniProtKB/Swiss-Prot
    P19493, Q64241
  2. XM_063265033.1XP_063121103.1  glutamate receptor 4 isoform X5

    UniProtKB/Swiss-Prot
    P19493, Q64241
  3. XM_063265031.1XP_063121101.1  glutamate receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    P19493, Q64241
  4. XM_017595511.3XP_017451000.1  glutamate receptor 4 isoform X2

    UniProtKB/Swiss-Prot
    P19493, Q64241
  5. XM_017595510.3XP_017450999.1  glutamate receptor 4 isoform X3

    UniProtKB/Swiss-Prot
    P19493, Q64241
  6. XM_039080969.2XP_038936897.1  glutamate receptor 4 isoform X6

    UniProtKB/Swiss-Prot
    P19493, Q64241
    Related
    ENSRNOP00000081710.2, ENSRNOT00000111725.2
    Conserved Domains (2) summary
    cd06388
    Location:28400
    PBP1_iGluR_AMPA_GluR4; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
    cl21456
    Location:414765
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RNA

  1. XR_010053935.1 RNA Sequence

  2. XR_010053936.1 RNA Sequence

  3. XR_010053937.1 RNA Sequence

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