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Gpat2 glycerol-3-phosphate acyltransferase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 296130, updated on 2-May-2024

Summary

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Official Symbol
Gpat2provided by RGD
Official Full Name
glycerol-3-phosphate acyltransferase 2, mitochondrialprovided by RGD
Primary source
RGD:1304904
See related
Ensembl:ENSRNOG00000013906 AllianceGenome:RGD:1304904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304904
Summary
Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity and glycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in several processes, including glycerol-3-phosphate metabolic process; glycerolipid biosynthetic process; and piRNA biosynthetic process. Located in mitochondrial outer membrane. Orthologous to human GPAT2 (glycerol-3-phosphate acyltransferase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 38.4), Kidney (RPKM 9.8) and 8 other tissues See more
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Genomic context

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Location:
3q36
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (135099751..135110355)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (114646446..114657051)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (119949921..120003090)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene astacin like metalloendopeptidase Neighboring gene adrenoceptor alpha 2B Neighboring gene fumarylacetoacetate hydrolase domain containing 2A Neighboring gene ribosomal protein L9, pseudogene 28

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Glycerol-3-phosphate acyltransferase-2 is expressed in spermatic germ cells and incorporates arachidonic acid into triacylglycerols. Cattaneo ER, et al. PLoS One, 2012. PMID 22905194, Free PMC Article
  2. Cloning and functional characterization of a novel mitochondrial N-ethylmaleimide-sensitive glycerol-3-phosphate acyltransferase (GPAT2). Wang S, et al. Arch Biochem Biophys, 2007 Sep 15. PMID 17689486, Free PMC Article
  3. Identification of a new glycerol-3-phosphate acyltransferase isoenzyme, mtGPAT2, in mitochondria. Lewin TM, et al. J Biol Chem, 2004 Apr 2. PMID 14724270
  4. GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells. Shiromoto Y, et al. RNA, 2013 Jun. PMID 23611983, Free PMC Article
  5. AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. Chen YQ, et al. J Biol Chem, 2008 Apr 11. PMID 18238778, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPAT2 expression is linked to arachidonoyl-CoA incorporation into TAG in spermatogenic germ cells
    Title: Glycerol-3-phosphate acyltransferase-2 is expressed in spermatic germ cells and incorporates arachidonic acid into triacylglycerols.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol-3-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycerol-3-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidic acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glycerol-3-phosphate acyltransferase 2, mitochondrial
Names
1-acylglycerol-3-phosphate O-acyltransferase GPAT2
NP_001162001.1
XP_017447069.1
XP_038960496.1
XP_038960497.1
XP_063139400.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168529.1 → NP_001162001.1  glycerol-3-phosphate acyltransferase 2, mitochondrial

    See identical proteins and their annotated locations for NP_001162001.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    D3ZI76
    UniProtKB/TrEMBL
    A0A8I5ZY97
    Related
    ENSRNOP00000018677.5, ENSRNOT00000018677.7
    Conserved Domains (1) summary
    cd07993
    Location:176 → 387
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    135099751..135110355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591580.2 → XP_017447069.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZY97
    Conserved Domains (1) summary
    cd07993
    Location:176 → 387
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

  2. XM_039104569.1 → XP_038960497.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X3

    UniProtKB/Swiss-Prot
    D3ZI76
    UniProtKB/TrEMBL
    A0A8I5ZY97
    Conserved Domains (1) summary
    cd07993
    Location:176 → 387
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

  3. XM_039104568.1 → XP_038960496.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZY97
    Conserved Domains (1) summary
    cd07993
    Location:176 → 387
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

  4. XM_063283330.1 → XP_063139400.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X4

RNA

  1. XR_005501820.1 RNA Sequence

  2. XR_010064581.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZI76.1 GenPept UniProtKB/Swiss-Prot:D3ZI76

Gene LinkOut

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