Spred1 sprouty-related, EVH1 domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spred1provided by RGD
Official Full Name: sprouty-related, EVH1 domain containing 1provided by RGD
Primary source: RGD:1308735
See related: Ensembl:ENSRNOG00000070996 AllianceGenome:RGD:1308735
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable enzyme binding activity; protein serine/threonine kinase inhibitor activity; and stem cell factor receptor binding activity. Predicted to be involved in several processes, including negative regulation of cell differentiation; regulation of protein modification process; and regulation of signal transduction. Located in cytoplasm and plasma membrane. Orthologous to human SPRED1 (sprouty related EVH1 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 163.5), Lung (RPKM 156.4) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3q35

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (124437230..124504358)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (103983120..104050321)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (108795337..108861650)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased expression of Sproutys and SPREDs during the terminal pseudoglandular stage may disrupt lung branching morphogenesis by interfering with epithelial-mesenchymal interactions contributing to PH.
Title: Expression of Sproutys and SPREDs is decreased during lung branching morphogenesis in nitrofen-induced pulmonary hypoplasia.
SPRED1 is a likely substrate of SHP2, whose tyrosine dephosphorylation is required to attenuate the inhibitory action of SPRED1 in the Ras/ERK pathway.
Title: Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein (SPRED1), a tyrosine-protein phosphatase non-receptor type 11 (SHP2) substrate in the Ras/extracellular signal-regulated kinase (ERK) pathway.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

D3Rat86 (e-PCR)
- UniSTS:118795

RH139669 (e-PCR)
- UniSTS:221753

BF390306 (e-PCR)
- UniSTS:249436

Spred1 (e-PCR), detects polymorphism
- UniSTS:528299

AU028930 (e-PCR)
- UniSTS:111855

Spred1 (e-PCR), detects polymorphism
- UniSTS:547837

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables stem cell factor receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lens fiber cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis involved in coronary vascular morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: sprouty-related, EVH1 domain-containing protein 1

Names: sprouty protein with EVH-1 domain 1, related sequence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001047089.2 → NP_001040554.1 sprouty-related, EVH1 domain-containing protein 1

See identical proteins and their annotated locations for NP_001040554.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I5ZRI8, A0A8I6AJF5, A6HP93, Q3C2P9

Related

ENSRNOP00000095328.1, ENSRNOT00000096496.1

Conserved Domains (2) summary

cd10574
Location:13 → 125

EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain

pfam05210
Location:333 → 428

Sprouty; Sprouty protein (Spry)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

124437230..124504358

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104539.2 → XP_038960467.1 sprouty-related, EVH1 domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I5ZRI8

Related

ENSRNOP00000086017.1

Conserved Domains (2) summary

cd10574
Location:1 → 104

EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain

pfam05210
Location:311 → 407

Sprouty; Sprouty protein (Spry)