P2ry2 purinergic receptor P2Y2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: P2ry2provided by RGD
Official Full Name: purinergic receptor P2Y2provided by RGD
Primary source: RGD:62088
See related: Ensembl:ENSRNOG00000019283 AllianceGenome:RGD:62088
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P2Y2
Summary: Enables A1 adenosine receptor binding activity; ATP binding activity; and G protein-coupled UTP receptor activity. Involved in several processes, including positive regulation of penile erection; regulation of cytosolic calcium ion concentration; and regulation of secretion by cell. Located in apical plasma membrane and basolateral plasma membrane. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Colocalizes with early endosome; lysosome; and mitochondrion. Used to study impotence. Orthologous to human P2RY2 (purinergic receptor P2Y2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 266.1), Muscle (RPKM 112.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (164764119..164779578, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (155352050..155367423, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (166031228..166045423, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P2Y1 and P2Y2 receptors differ in their role in the regulation of signaling pathways during unloading-induced rat soleus muscle atrophy.
Title: P2Y1 and P2Y2 receptors differ in their role in the regulation of signaling pathways during unloading-induced rat soleus muscle atrophy.
P2Y2 Receptor Mediated Neuronal Regeneration and Angiogenesis to Affect Functional Recovery in Rats with Spinal Cord Injury.
Title: P2Y2 Receptor Mediated Neuronal Regeneration and Angiogenesis to Affect Functional Recovery in Rats with Spinal Cord Injury.
P2RY2 Alleviates Cerebral Ischemia-Reperfusion Injury by Inhibiting YAP Phosphorylation and Reducing Mitochondrial Fission.
Title: P2RY2 Alleviates Cerebral Ischemia-Reperfusion Injury by Inhibiting YAP Phosphorylation and Reducing Mitochondrial Fission.
Expanding Role of Dopaminergic Inhibition in Hypercapnic Responses of Cultured Rat Carotid Body Cells: Involvement of Type II Glial Cells.
Title: Expanding Role of Dopaminergic Inhibition in Hypercapnic Responses of Cultured Rat Carotid Body Cells: Involvement of Type II Glial Cells.
The authors concluded that P2Y2R participates in controlling the proliferative rate of theca cells from healthy ovaries, but this regulation is lost during experimentally-induced polycystic ovarian syndrome.
Title: Experimental polycystic ovarian syndrome is associated with reduced expression and function of P2Y2 receptors in rat theca cells.
downregulation of P2Y2 and HuD may partly be related to the development of the enteric nervous system in anorectal malformations embryos.
Title: Downregulation of P2Y2 and HuD during the development of the enteric nervous system in fetal rats with anorectal malformations.
lysosomal exocytosis of ATP is coupled to P2Y2 receptor in marginal cells in the stria vascular in neonatal rats
Title: Lysosomal exocytosis of ATP is coupled to P2Y(2) receptor in marginal cells in the stria vascular in neonatal rats.
study suggests that P2Y2R is involved in regulation of bone turnover
Title: Bone turnover is altered in transgenic rats overexpressing the P2Y2 purinergic receptor.
Activation of renal medullary P2Y2/P2Y4 receptors promotes ET-1-dependent natriuresis in ovariectomized rats.
Title: Ovariectomy uncovers purinergic receptor activation of endothelin-dependent natriuresis.
Uridine triphosphate regulates the osteogenic and adipogenic differentiation of bone marrow-derived stromal cells via the P2Y2 receptor.
Title: Regulation of the osteogenic and adipogenic differentiation of bone marrow-derived stromal cells by extracellular uridine triphosphate: The role of P2Y2 receptor and ERK1/2 signaling.

Submit: New GeneRIF Correction See all GeneRIFs (47)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables A1 adenosine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables A1 adenosine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled UTP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled UTP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled purinergic nucleotide receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood vessel diameter maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to purine-containing compound	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEP Inferred from Expression Pattern more info	PubMed
NOT involved_in microglial cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mucus secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ossification	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mucus secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of mucus secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of penile erection	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of prostaglandin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	EXP Inferred from Experiment more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	EXP Inferred from Experiment more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to growth factor	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: P2Y purinoceptor 2

Names: ATP receptor; P2U purinoceptor 1; P2U1; P2Y ATP receptor 2; purinergic receptor P2Y, G-protein coupled, 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017255.2 → NP_058951.2 P2Y purinoceptor 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P41232

UniProtKB/TrEMBL

A6I6S6, G3V8H8

Related

ENSRNOP00000077949.1, ENSRNOT00000114931.1

Conserved Domains (1) summary

cd15373
Location:34 → 316

7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

164764119..164779578 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229757.5 → XP_006229819.1 P2Y purinoceptor 2 isoform X1

See identical proteins and their annotated locations for XP_006229819.1

UniProtKB/Swiss-Prot

P41232

UniProtKB/TrEMBL

A6I6S6, G3V8H8

Conserved Domains (1) summary

cd15373
Location:34 → 316

7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_039109599.2 → XP_038965527.1 P2Y purinoceptor 2 isoform X1

UniProtKB/Swiss-Prot

P41232

UniProtKB/TrEMBL

A6I6S6, G3V8H8

Related

ENSRNOP00000026115.3

Conserved Domains (1) summary

cd15373
Location:34 → 316

7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_063287642.1 → XP_063143712.1 P2Y purinoceptor 2 isoform X1

UniProtKB/TrEMBL

A6I6S6, G3V8H8