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Htr2b 5-hydroxytryptamine receptor 2B [ Rattus norvegicus (Norway rat) ]

Gene ID: 29581, updated on 4-Jan-2025

Summary

Official Symbol
Htr2bprovided by RGD
Official Full Name
5-hydroxytryptamine receptor 2Bprovided by RGD
Primary source
RGD:61801
See related
EnsemblRapid:ENSRNOG00000017625 AllianceGenome:RGD:61801
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
5-HT2B; 5-HT-2B; 5-HT-2F
Summary
Enables serotonin binding activity. Involved in several processes, including cellular response to serotonin; hepatic stellate cell activation; and inositol phosphate metabolic process. Located in dendrite; neuronal cell body; and plasma membrane. Used to study heart valve disease. Biomarker of brain infarction and congestive heart failure. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatohepatitis and steatotic liver disease. Orthologous to human HTR2B (5-hydroxytryptamine receptor 2B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 22.8), Thymus (RPKM 22.5) and 9 other tissues See more
Orthologs
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Genomic context

See Htr2b in Genome Data Viewer
Location:
9q35
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (94184442..94206851, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (86735793..86756638, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (93112781..93130135, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094731 Neighboring gene similar to human chromosome 2 open reading frame 72 Neighboring gene uncharacterized LOC134480602 Neighboring gene proteasome 26S subunit, non-ATPase 1 Neighboring gene armadillo repeat containing 9 Neighboring gene uncharacterized LOC102548542 Neighboring gene transfer RNA proline (anticodon AGG) 49

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled serotonin receptor activity  
enables G protein-coupled serotonin receptor activity  
enables G protein-coupled serotonin receptor activity  
enables G-protein alpha-subunit binding  
enables G-protein alpha-subunit binding  
enables G-protein alpha-subunit binding  
enables GTPase activator activity  
enables GTPase activator activity  
enables GTPase activator activity  
enables Gq/11-coupled serotonin receptor activity  
enables Gq/11-coupled serotonin receptor activity  
enables neurotransmitter receptor activity  
enables protein binding PubMed 
enables serotonin binding PubMed 
enables serotonin binding  
enables serotonin binding  
enables serotonin binding  
enables serotonin receptor activity  
enables serotonin receptor activity  
Items 1 - 25 of 80
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade  
involved_in ERK1 and ERK2 cascade  
involved_in ERK1 and ERK2 cascade  
involved_in G protein-coupled receptor signaling pathway  
involved_in G protein-coupled receptor signaling pathway  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  
involved_in G protein-coupled serotonin receptor signaling pathway  
involved_in G protein-coupled serotonin receptor signaling pathway  
involved_in cGMP-mediated signaling  
involved_in cGMP-mediated signaling  
involved_in cGMP-mediated signaling  
involved_in calcium-mediated signaling  
involved_in calcium-mediated signaling  
involved_in calcium-mediated signaling  
involved_in cardiac muscle hypertrophy  
involved_in cardiac muscle hypertrophy  
involved_in cardiac muscle hypertrophy  
involved_in cellular response to amine stimulus PubMed 
involved_in cellular response to serotonin PubMed 
involved_in chemical synaptic transmission  
involved_in embryonic morphogenesis  
involved_in embryonic morphogenesis  
involved_in embryonic morphogenesis  
acts_upstream_of_or_within heart development  
involved_in heart morphogenesis  
involved_in heart morphogenesis  
involved_in heart morphogenesis  
involved_in hepatic stellate cell activation PubMed 
involved_in inositol phosphate metabolic process PubMed 
involved_in intestine smooth muscle contraction  
involved_in intestine smooth muscle contraction  
involved_in intestine smooth muscle contraction  
involved_in intracellular calcium ion homeostasis  
involved_in intracellular calcium ion homeostasis  
involved_in monoatomic ion transmembrane transport PubMed 
involved_in negative regulation of apoptotic process  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of apoptotic process  
involved_in neural crest cell differentiation  
involved_in neural crest cell differentiation  
involved_in neural crest cell migration  
involved_in neural crest cell migration  
involved_in neural crest cell migration  
involved_in phospholipase C-activating serotonin receptor signaling pathway  
involved_in phospholipase C-activating serotonin receptor signaling pathway  
involved_in phospholipase C-activating serotonin receptor signaling pathway  
involved_in phospholipase C-activating serotonin receptor signaling pathway  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of canonical NF-kappaB signal transduction  
involved_in positive regulation of canonical NF-kappaB signal transduction  
involved_in positive regulation of canonical NF-kappaB signal transduction  
involved_in positive regulation of cell division  
involved_in positive regulation of cell division  
involved_in positive regulation of cell division  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cytokine production  
involved_in positive regulation of cytokine production  
involved_in positive regulation of cytokine production  
involved_in positive regulation of endothelial cell proliferation  
involved_in positive regulation of endothelial cell proliferation  
involved_in positive regulation of endothelial cell proliferation  
involved_in positive regulation of phosphatidylinositol biosynthetic process  
involved_in positive regulation of phosphatidylinositol biosynthetic process  
involved_in positive regulation of phosphatidylinositol biosynthetic process  
involved_in regulation of behavior  
involved_in regulation of behavior  
involved_in regulation of behavior  
involved_in release of sequestered calcium ion into cytosol  
involved_in release of sequestered calcium ion into cytosol  
involved_in release of sequestered calcium ion into cytosol  
involved_in release of sequestered calcium ion into cytosol  
involved_in response to xenobiotic stimulus  
involved_in response to xenobiotic stimulus  
involved_in serotonin receptor signaling pathway  
involved_in vasoconstriction  
involved_in vasoconstriction  
involved_in vasoconstriction  
Items 1 - 25 of 80
Component Evidence Code Pubs
part_of G protein-coupled serotonin receptor complex  
part_of G protein-coupled serotonin receptor complex  
located_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  
is_active_in dendrite  
located_in dendrite PubMed 
located_in neuron projection  
located_in neuronal cell body PubMed 
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in synapse  

General protein information

Preferred Names
5-hydroxytryptamine receptor 2B
Names
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
serotonin receptor 2B
stomach fundus serotonin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017250.2NP_058946.2  5-hydroxytryptamine receptor 2B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    P30994, Q9QW44
    UniProtKB/TrEMBL
    A6JWG0, G3V8A0
    Related
    ENSRNOP00000023829.3, ENSRNOT00000023829.6
    Conserved Domains (2) summary
    cd14964
    Location:5581
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:54397
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    94184442..94206851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083116.2XP_038939044.1  5-hydroxytryptamine receptor 2B isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:5581
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:54183
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_063266817.1XP_063122887.1  5-hydroxytryptamine receptor 2B isoform X1

    UniProtKB/Swiss-Prot
    P30994, Q9QW44
    UniProtKB/TrEMBL
    A6JWG0, G3V8A0
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