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Ggt5 gamma-glutamyltransferase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29566, updated on 5-Mar-2024

Summary

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Official Symbol
Ggt5provided by RGD
Official Full Name
gamma-glutamyltransferase 5provided by RGD
Primary source
RGD:2684
See related
Ensembl:ENSRNOG00000062276 AllianceGenome:RGD:2684
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ggta1; Ggtla1
Summary
Predicted to enable glutathione hydrolase activity; leukotriene-C(4) hydrolase; and peptidyltransferase activity. Involved in response to organonitrogen compound. Predicted to be intrinsic component of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human GGT5 (gamma-glutamyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 21.6), Heart (RPKM 16.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
20p12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (13042694..13070960, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (13043255..13071523, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13988444..14001296, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene calcineurin binding protein 1 Neighboring gene uncharacterized LOC102556116 Neighboring gene sushi domain containing 2 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120098976 Neighboring gene gamma-glutamyltransferase 1 Neighboring gene leucine rich repeat containing 75B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene family member, is expressed primarily in spleen. Carter BZ, et al. J Biol Chem, 1998 Oct 23. PMID 9774450
  2. Expression and regulation of gamma-glutamyl transpeptidase-related enzyme in tracheal cells. Potdar PD, et al. Am J Physiol, 1997 Nov. PMID 9374738
  3. Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase. Heisterkamp N, et al. Proc Natl Acad Sci U S A, 1991 Jul 15. PMID 1676842, Free PMC Article
  4. Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo. Han B, et al. Am J Pathol, 2002 Aug. PMID 12163373, Free PMC Article
  5. Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. Wickham S, et al. Anal Biochem, 2011 Jul 15. PMID 21447318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC93485

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables leukotriene C4 gamma-glutamyl transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables leukotriene-C(4) hydrolase IBA
Inferred from Biological aspect of Ancestor
more info
  
enables leukotriene-C(4) hydrolase IEA
Inferred from Electronic Annotation
more info
  
enables leukotriene-C(4) hydrolase ISO
Inferred from Sequence Orthology
more info
  
enables leukotriene-C(4) hydrolase ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptidyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in amino acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glutathione catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in leukotriene D4 biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leukotriene D4 biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within leukotriene D4 biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in leukotriene D4 biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in leukotriene D4 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to oxidative stress TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glutathione hydrolase 5 proenzyme
Names
GGL
GGT 5
GGT-rel
gamma-glutamyl leukotrienase
gamma-glutamyl transpeptidase-related enzyme
gamma-glutamyltransferase-like activity 1
gamma-glutamyltranspeptidase 5
leukotriene-C4 hydrolase
NP_062108.2
XP_038954554.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019235.2 → NP_062108.2  glutathione hydrolase 5 proenzyme

    See identical proteins and their annotated locations for NP_062108.2

    Status: PROVISIONAL

    Source sequence(s)
    BC087018
    UniProtKB/Swiss-Prot
    Q5PQV0, Q9QWE9
    Related
    ENSRNOP00000076334.2, ENSRNOT00000093720.2
    Conserved Domains (1) summary
    pfam01019
    Location:60 → 567
    G_glu_transpept; Gamma-glutamyltranspeptidase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    13042694..13070960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098626.2 → XP_038954554.1  glutathione hydrolase 5 proenzyme isoform X1

    Conserved Domains (1) summary
    pfam01019
    Location:60 → 524
    G_glu_transpept; Gamma-glutamyltranspeptidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QWE9.2 GenPept UniProtKB/Swiss-Prot:Q9QWE9

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous