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Ptgs2 prostaglandin-endoperoxide synthase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29527, updated on 4-Jan-2025

Summary

Official Symbol
Ptgs2provided by RGD
Official Full Name
prostaglandin-endoperoxide synthase 2provided by RGD
Primary source
RGD:620349
See related
EnsemblRapid:ENSRNOG00000002525 AllianceGenome:RGD:620349
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cox2; COX-2; PGHS-2; PHS II
Summary
Enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and positive regulation of cytokine production. Acts upstream of or within bone mineralization. Located in caveola and cytoplasm. Part of protein-containing complex. Used to study several diseases, including brain disease (multiple); hypertension (multiple); liver disease (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including carcinoma (multiple); glioblastoma (multiple); inflammatory bowel disease (multiple); pleurisy; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); avian influenza; cardiovascular system disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 161.3), Brain (RPKM 53.0) and 4 other tissues See more
Orthologs
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Genomic context

See Ptgs2 in Genome Data Viewer
Location:
13q21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (64714063..64722320)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (62163936..62172193)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (67351230..67356920)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 208, pseudogene 1 Neighboring gene prostaglandin-endoperoxide synthase 2, opposite strand Neighboring gene monooxygenase like, pseudogene 1 Neighboring gene phosducin

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 74
Process Evidence Code Pubs
involved_in angiogenesis PubMed 
acts_upstream_of_or_within bone mineralization PubMed 
involved_in brown fat cell differentiation  
involved_in cellular oxidant detoxification  
involved_in cellular response to ATP PubMed 
acts_upstream_of_or_within cellular response to fluid shear stress  
involved_in cellular response to heat PubMed 
involved_in cellular response to homocysteine PubMed 
involved_in cellular response to hypoxia  
involved_in cellular response to lead ion PubMed 
involved_in cellular response to lipopolysaccharide PubMed 
involved_in cellular response to mechanical stimulus PubMed 
involved_in cellular response to non-ionic osmotic stress  
involved_in cyclooxygenase pathway  
acts_upstream_of_or_within cyclooxygenase pathway  
involved_in cyclooxygenase pathway  
involved_in cyclooxygenase pathway  
involved_in decidualization PubMed 
acts_upstream_of_or_within decidualization  
involved_in embryo implantation PubMed 
acts_upstream_of_or_within embryo implantation  
involved_in hair cycle PubMed 
involved_in learning PubMed 
involved_in maintenance of blood-brain barrier PubMed 
involved_in memory PubMed 
involved_in negative regulation of apoptotic process  
involved_in negative regulation of calcium ion transport PubMed 
involved_in negative regulation of cell cycle PubMed 
involved_in negative regulation of cell population proliferation PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress  
involved_in negative regulation of smooth muscle contraction PubMed 
involved_in negative regulation of synaptic transmission, dopaminergic PubMed 
involved_in positive regulation of apoptotic process PubMed 
involved_in positive regulation of brown fat cell differentiation  
involved_in positive regulation of cell migration involved in sprouting angiogenesis PubMed 
involved_in positive regulation of cell population proliferation PubMed 
involved_in positive regulation of fever generation PubMed 
involved_in positive regulation of fever generation  
involved_in positive regulation of fibroblast growth factor production PubMed 
involved_in positive regulation of nitric oxide biosynthetic process PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation  
involved_in positive regulation of platelet-derived growth factor production PubMed 
involved_in positive regulation of prostaglandin biosynthetic process  
involved_in positive regulation of protein import into nucleus PubMed 
involved_in positive regulation of smooth muscle cell proliferation PubMed 
involved_in positive regulation of smooth muscle contraction PubMed 
involved_in positive regulation of synaptic plasticity PubMed 
involved_in positive regulation of synaptic transmission, glutamatergic PubMed 
involved_in positive regulation of transforming growth factor beta production PubMed 
involved_in positive regulation of vascular endothelial growth factor production PubMed 
involved_in positive regulation of vasoconstriction PubMed 
involved_in prostaglandin biosynthetic process PubMed 
involved_in prostaglandin biosynthetic process  
acts_upstream_of_or_within prostaglandin secretion  
acts_upstream_of_or_within regulation of blood pressure  
involved_in regulation of blood pressure  
acts_upstream_of_or_within regulation of cell population proliferation  
involved_in regulation of neuroinflammatory response  
involved_in regulation of neuroinflammatory response  
involved_in response to angiotensin PubMed 
involved_in response to cytokine PubMed 
involved_in response to estradiol PubMed 
involved_in response to fatty acid PubMed 
involved_in response to fructose PubMed 
involved_in response to glucocorticoid PubMed 
involved_in response to lipopolysaccharide PubMed 
involved_in response to manganese ion PubMed 
acts_upstream_of_or_within response to nematode  
involved_in response to oxidative stress  
involved_in response to selenium ion  
acts_upstream_of_or_within response to selenium ion  
involved_in response to tumor necrosis factor PubMed 
involved_in response to vitamin D PubMed 
involved_in response to xenobiotic stimulus PubMed 
Items 1 - 25 of 74
Component Evidence Code Pubs
located_in caveola PubMed 
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in cytoplasm  
located_in endoplasmic reticulum  
located_in endoplasmic reticulum membrane  
is_active_in neuron projection  
located_in neuron projection  
located_in nuclear inner membrane  
located_in nuclear inner membrane  
located_in nuclear outer membrane  
located_in nuclear outer membrane  
NOT located_in nucleus  
part_of protein-containing complex PubMed 

General protein information

Preferred Names
prostaglandin G/H synthase 2
Names
PGH synthase 2
cyclooxygenase-2
prostaglandin H2 synthase 2
NP_058928.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017232.4NP_058928.3  prostaglandin G/H synthase 2 precursor

    See identical proteins and their annotated locations for NP_058928.3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    P35355, Q64379, Q925V4
    UniProtKB/TrEMBL
    A6ICR0, Q63124
    Related
    ENSRNOP00000003567.3, ENSRNOT00000003567.6
    Conserved Domains (2) summary
    cd09816
    Location:75562
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    pfam00008
    Location:2153
    EGF; EGF-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    64714063..64722320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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