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Mapk13 mitogen activated protein kinase 13 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29513, updated on 11-Apr-2024

Summary

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Official Symbol
Mapk13provided by RGD
Official Full Name
mitogen activated protein kinase 13provided by RGD
Primary source
RGD:3045
See related
Ensembl:ENSRNOG00000000515 AllianceGenome:RGD:3045
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Prkm13
Summary
Enables ATP binding activity and MAP kinase activity. Involved in protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPK13 (mitogen-activated protein kinase 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 272.5), Lung (RPKM 47.0) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
20p12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (6836979..6847197)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (6835277..6845500)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (6018374..6027467)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene mitogen activated protein kinase 14 Neighboring gene uncharacterized LOC134483779 Neighboring gene bromodomain and PHD finger containing, 3 Neighboring gene uncharacterized LOC134483867 Neighboring gene uncharacterized LOC120098863 Neighboring gene patatin-like phospholipase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. p38 MAPK regulates G1-S transition in hypoxic cardiac fibroblasts. Pillai MS, et al. Int J Biochem Cell Biol, 2011 Jun. PMID 21420505
  2. Rat mesothelioma cell proliferation requires p38δ mitogen activated protein kinase and C/EBP-α. Zhong J, et al. Lung Cancer, 2011 Aug. PMID 21227534
  3. Identification of stathmin as a novel substrate for p38 delta. Parker CG, et al. Biochem Biophys Res Commun, 1998 Aug 28. PMID 9731215
  4. Microtubular stability affects pVHL-mediated regulation of HIF-1alpha via the p38/MAPK pathway in hypoxic cardiomyocytes. Teng M, et al. PLoS One, 2012. PMID 22506063, Free PMC Article
  5. Physiological loading of joints prevents cartilage degradation through CITED2. Leong DJ, et al. FASEB J, 2011 Jan. PMID 20826544, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
    Title: The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas.
  2. Microtubular structure breakdown activated p38/MAPK pathway, accompanied with the upregulation of pVHL.
    Title: Microtubular stability affects pVHL-mediated regulation of HIF-1alpha via the p38/MAPK pathway in hypoxic cardiomyocytes.
  3. in pleural mesothelioma, p38 delta and C/EBP-alpha mediate proliferation and thus may represent new targets in mesothelioma therapy
    Title: Rat mesothelioma cell proliferation requires p38δ mitogen activated protein kinase and C/EBP-α.
  4. regulates G1-S transition in hypoxic cardiac fibroblasts
    Title: p38 MAPK regulates G1-S transition in hypoxic cardiac fibroblasts.
  5. Studies identify a novel regulatory pathway involving CITED2 and p38delta, which may be critical for the maintenance of articular cartilage integrity under normal physical activity levels.
    Title: Physiological loading of joints prevents cartilage degradation through CITED2.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC124619

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to UV IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to anisomycin IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to anisomycin ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to sodium arsenite IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to sodium arsenite ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to sorbitol IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to sorbitol ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in response to osmotic stress IEA
Inferred from Electronic Annotation
more info
  
involved_in response to osmotic stress ISO
Inferred from Sequence Orthology
more info
  
involved_in stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in stress-activated MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase 13
Names
MAP kinase 13
MAP kinase p38 delta
MAPK 13
mitogen-activated protein kinase p38 delta
stress-activated protein kinase 4
NP_062104.3
XP_038954553.1
XP_063135153.1
XP_063135154.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019231.3 → NP_062104.3  mitogen-activated protein kinase 13

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A6JJS2, G3V618, Q32Q45
    Related
    ENSRNOP00000000621.3, ENSRNOT00000000621.7
    Conserved Domains (1) summary
    cd07879
    Location:9 → 351
    STKc_p38delta; Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase (also called MAPK13)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    6836979..6847197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279083.1 → XP_063135153.1  mitogen-activated protein kinase 13 isoform X1

  2. XM_063279084.1 → XP_063135154.1  mitogen-activated protein kinase 13 isoform X3

  3. XM_039098625.2 → XP_038954553.1  mitogen-activated protein kinase 13 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1 → 273
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTY9.1 GenPept UniProtKB/Swiss-Prot:Q9WTY9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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