Gstt2 glutathione S-transferase theta 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gstt2provided by RGD
Official Full Name: glutathione S-transferase theta 2provided by RGD
Primary source: RGD:69362
See related: Ensembl:ENSRNOG00000052415 AllianceGenome:RGD:69362
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables glutathione peroxidase activity and glutathione transferase activity. Involved in response to salicylic acid. Acts upstream of or within glutathione metabolic process. Located in cytosol and nucleus. Biomarker of Charcot-Marie-Tooth disease. Orthologous to human GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 533.3), Adrenal (RPKM 528.5) and 9 other tissues See more
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Genomic context

Location:: 20p12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (12819053..12822724)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (12819617..12823288)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (13760810..13764481)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proanthocyanidins mitigate bile acid-induced changes in GSTT2 levels in a panel of racially diverse patient-derived primary esophageal cell cultures.
Title: Proanthocyanidins mitigate bile acid-induced changes in GSTT2 levels in a panel of racially diverse patient-derived primary esophageal cell cultures.

Submit: New GeneRIF Correction

General gene information

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Markers

BF415458 (e-PCR)
- UniSTS:248899

D20Wox21 (e-PCR)
- UniSTS:518725

RH130215 (e-PCR)
- UniSTS:213502

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to salicylic acid	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutathione S-transferase theta-2

Names: GST 12-12; GST class-theta-2; glutathione S-transferase 12; glutathione S-transferase Yrs-Yrs; glutathione S-transferase theta-2-like

NP_036928.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012796.2 → NP_036928.1 glutathione S-transferase theta-2

See identical proteins and their annotated locations for NP_036928.1

Status: VALIDATED

Source sequence(s)

CK473092, JAXUCZ010000020

UniProtKB/Swiss-Prot

P30713, P36971

UniProtKB/TrEMBL

A0A8L2R9M6, B6DYQ9

Related

ENSRNOP00000074436.2, ENSRNOT00000080203.2

Conserved Domains (2) summary

cd03183
Location:91 → 216

GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases

cd03050
Location:3 → 78

GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...