Rxfp3 relaxin family peptide receptor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rxfp3provided by RGD
Official Full Name: relaxin family peptide receptor 3provided by RGD
Primary source: RGD:1311550
See related: Ensembl:ENSRNOG00000023126 AllianceGenome:RGD:1311550
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Salpr; Rln3r1; GPCR135; RGD1311550
Summary: Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in neuropeptide signaling pathway and positive regulation of cytokinesis. Predicted to act upstream of or within positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to be integral component of plasma membrane. Orthologous to human RXFP3 (relaxin family peptide receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (61730376..61731806, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (60003256..60004686, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (61006337..61007767, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular Neurons via M-like Current Activation and Contributes to Binge Eating Behavior.
Title: RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular Neurons via M-like Current Activation and Contributes to Binge Eating Behavior.
Activation of RXFP3 in the nucleus of the solitary tract selectively modulates respiration.
Title: Relaxin-3 receptor (RXFP3) activation in the nucleus of the solitary tract modulates respiratory rate and the arterial chemoreceptor reflex in rat.
Relaxin-1 mRNA in the hearts of diabetic rats was significantly increased and that relaxin-3 mRNA expression at different time points was decreased. In addition, significant down-regulation of the mRNA expression of RXFP1 and RXFP3 was observed at 4 weeks after Streptozocin.
Title: Alterations of relaxin and its receptor system components in experimental diabetic cardiomyopathy rats.
Relaxin-3/RXFP3 signaling within the central amygdala contributes to yohimbine-induced reinstatement of alcohol seeking. We therefore suggest that the relaxin-3/RXFP3 system represents a legitimate potential target for the treatment of both anxiety and substance use disorders.
Title: Central amygdala relaxin-3/relaxin family peptide receptor 3 signalling modulates alcohol seeking in rats.
the relaxin-3 B-chain C-terminus changes from the original folding-back conformation to an extended conformation during binding with RXFP3, to allow its B27Trp and B26Arg residues to interact with the Trp138 and Glu141 residues of RXFP3, respectively.
Title: Identification of hydrophobic interactions between relaxin-3 and its receptor RXFP3: implication for a conformational change in the B-chain C-terminus during receptor binding.
The presence of central relaxin-3 receptor (RXFP3)-like immunoreactivity and the RXFP3-related activation of the MAPK/ERK pathway in medial septum/diagonal band cholinergic neurons identifies them as a key target of ascending relaxin-3 projections with implications for the acute and chronic modulation of cholinergic neuron activity and function by relaxin-3/RXFP3 signaling.
Title: Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons and impairs spatial working memory.
Results suggest that changes in relaxin family peptides (RXFP3, RXFP1) may contribute to the significant sex differences observed in the hippocampus and amygdala as a function of aging
Title: Sex- and age-specific differences in relaxin family peptide receptor expression within the hippocampus and amygdala in rats.
high endogenous relaxin-3 expression may be associated with higher intake of rewarding substances, rather than its expression being regulated in response to their intake
Title: Relaxin-3 mRNA levels in nucleus incertus correlate with alcohol and sucrose intake in rats.
Diet-induced obese rats show an increase in relaxin-3 expression in the brain and refeeding after food deprivation may enhance the orexigenic effects of relaxin-3 by rapid upregulation of the expression of RXFP3
Title: Regulation of expression of relaxin-3 and its receptor RXFP3 in the brain of diet-induced obese rats.
These data suggest that relaxin-3/RXFP3 signaling regulates alcohol intake and relapse-like behavior, adding to current knowledge of the brain chemistry of reward-seeking.
Title: Relaxin-3/RXFP3 system regulates alcohol-seeking.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled peptide receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: relaxin-3 receptor 1

Names: G-protein coupled receptor SALPR; relaxin-3/INSL7 receptor 1; relaxin/insulin-like family peptide receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.