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Gtf2h2 general transcription factor IIH subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294693, updated on 5-Mar-2024

Summary

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Official Symbol
Gtf2h2provided by RGD
Official Full Name
general transcription factor IIH subunit 2provided by RGD
Primary source
RGD:1310499
See related
Ensembl:ENSRNOG00000018230 AllianceGenome:RGD:1310499
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
BTF2 p44
Summary
Predicted to enable zinc ion binding activity. Predicted to be involved in nucleotide-excision repair; regulation of transcription by RNA polymerase II; and transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be part of core TFIIH complex portion of holo TFIIH complex. Orthologous to several human genes including GTF2H2C (GTF2H2 family member C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 68.4), Thymus (RPKM 68.4) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2q12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (33358863..33386726, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (31623752..31652697, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (30494718..30522716, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene survival of motor neuron 1, telomeric Neighboring gene NLR family, apoptosis inhibitory protein 6 Neighboring gene NLR family, apoptosis inhibitory protein 5 Neighboring gene ribosomal protein eL22-like 1 Neighboring gene occludin Neighboring gene RNA, U4 small nuclear 64

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The role of XPC: implications in cancer and oxidative DNA damage. Melis JP, et al. Mutat Res, 2011 Nov-Dec. PMID 21763452, Free PMC Article
  2. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. Egly JM, et al. DNA Repair (Amst), 2011 Jul 15. PMID 21592869
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of core TFIIH complex portion of holo TFIIH complex ISO
Inferred from Sequence Orthology
more info
  
part_of core TFIIH complex portion of holo TFIIH complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIH core complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIH core complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIH holo complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIH holo complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
general transcription factor IIH subunit 2
Names
BTF2-p44
TFIIH basal transcription factor complex p44 subunit
basic transcription factor 2 44 kDa subunit
general transcription factor IIH, polypeptide 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077428.1 → NP_001070896.1  general transcription factor IIH subunit 2

    See identical proteins and their annotated locations for NP_001070896.1

    Status: PROVISIONAL

    Source sequence(s)
    BC126097
    UniProtKB/Swiss-Prot
    A0JN27
    UniProtKB/TrEMBL
    A6I592
    Related
    ENSRNOP00000086669.1, ENSRNOT00000116668.1
    Conserved Domains (2) summary
    COG5151
    Location:11 → 386
    SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]
    cd01453
    Location:56 → 240
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    33358863..33386726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231844.5 → XP_006231906.1  general transcription factor IIH subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006231906.1

    UniProtKB/Swiss-Prot
    A0JN27
    UniProtKB/TrEMBL
    A6I592
    Related
    ENSRNOP00000057895.2
    Conserved Domains (2) summary
    COG5151
    Location:11 → 386
    SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]
    cd01453
    Location:56 → 240
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...

  2. XM_006231845.5 → XP_006231907.1  general transcription factor IIH subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006231907.1

    UniProtKB/Swiss-Prot
    A0JN27
    UniProtKB/TrEMBL
    A6I592
    Conserved Domains (2) summary
    COG5151
    Location:11 → 386
    SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]
    cd01453
    Location:56 → 240
    vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...

  3. XM_063281499.1 → XP_063137569.1  general transcription factor IIH subunit 2 isoform X2

RNA

  1. XR_005500254.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0JN27.1 GenPept UniProtKB/Swiss-Prot:A0JN27

Gene LinkOut

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