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Ppa1 inorganic pyrophosphatase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294504, updated on 11-Apr-2024

Summary

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Official Symbol
Ppa1provided by RGD
Official Full Name
inorganic pyrophosphatase 1provided by RGD
Primary source
RGD:1589773
See related
Ensembl:ENSRNOG00000063854 AllianceGenome:RGD:1589773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pp; Pyp
Summary
Predicted to enable pyrophosphatase activity. Predicted to be involved in phosphate-containing compound metabolic process. Predicted to be located in cytoplasm. Orthologous to human PPA1 (inorganic pyrophosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 487.9), Heart (RPKM 307.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
20q11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (30132088..30160492)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (29590733..29617711)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (31265519..31292451)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 20 Neighboring gene ribosomal protein L27, pseudogene 8 Neighboring gene uncharacterized LOC134483917 Neighboring gene neuropeptide FF receptor 1 Neighboring gene secretion associated, Ras related GTPase 1A Neighboring gene trypsin like peroxisomal matrix peptidase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning, expression, and functional analysis of rat liver cytosolic inorganic pyrophosphatase gene and characterization of its functional promoter. Panda H, et al. Gene Expr, 2007. PMID 17933215, Free PMC Article
  2. Age-dependent differential expression and activity of rat liver cytosolic inorganic pyrophosphatase gene. Panda H, et al. Biogerontology, 2007 Oct. PMID 17415680
  3. Studies on human erythrocyte inorganic pyrophosphatase. Fisher RA, et al. Ann Hum Genet, 1974 Jan. PMID 4130389
  4. Purification and kinetic properties of human erythrocyte Mg2+-dependent inorganic pyrophosphatase. Thuillier L. Biochim Biophys Acta, 1978 May 11. PMID 656444
  5. Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids. Yasue M, et al. Cytogenet Cell Genet, 1991. PMID 1914521

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. There is an age-associated increase (approximately 2-fold) in the expression of rat liver cytosolic iPPase gene by differential display PCR and northern blot analysis.
    Title: Age-dependent differential expression and activity of rat liver cytosolic inorganic pyrophosphatase gene.
  2. Cloning, expression, and functional analysis of rat liver cytosolic Pyp gene and characterization of its functional promoter are reported.
    Title: Cloning, expression, and functional analysis of rat liver cytosolic inorganic pyrophosphatase gene and characterization of its functional promoter.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables inorganic diphosphate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pyrophosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in COPII vesicle coating IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphate-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inorganic pyrophosphatase
Names
pyrophosphatase (inorganic) 1
pyrophosphatase 1
NP_001094304.1
XP_038954538.1
XP_063135139.1
XP_063135140.1
XP_063135141.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100834.1 → NP_001094304.1  inorganic pyrophosphatase

    Status: VALIDATED

    Source sequence(s)
    BC099794
    UniProtKB/TrEMBL
    F7EPH4
    Related
    ENSRNOP00000000674.6, ENSRNOT00000000674.7
    Conserved Domains (1) summary
    cl00217
    Location:2 → 241
    pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    30132088..30160492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279070.1 → XP_063135140.1  inorganic pyrophosphatase isoform X3

  2. XM_063279069.1 → XP_063135139.1  inorganic pyrophosphatase isoform X2

  3. XM_039098610.2 → XP_038954538.1  inorganic pyrophosphatase isoform X1

    UniProtKB/TrEMBL
    A0A0G2JUD2, F7EPH4
    Related
    ENSRNOP00000069053.2
    Conserved Domains (1) summary
    cl00217
    Location:2 → 263
    pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.

  4. XM_063279071.1 → XP_063135141.1  inorganic pyrophosphatase isoform X4

    UniProtKB/TrEMBL
    A0A8I6GET1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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