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Tfpi tissue factor pathway inhibitor [ Rattus norvegicus (Norway rat) ]

Gene ID: 29436, updated on 11-Apr-2024

Summary

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Official Symbol
Tfpiprovided by RGD
Official Full Name
tissue factor pathway inhibitorprovided by RGD
Primary source
RGD:61914
See related
Ensembl:ENSRNOG00000005039 AllianceGenome:RGD:61914
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in cellular response to interleukin-1; cellular response to lipopolysaccharide; and response to estradiol. Located in extracellular space. Biomarker of atrial fibrillation; disseminated intravascular coagulation; myocardial infarction; and osteonecrosis. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; osteonecrosis; thrombophilia (multiple); toxic shock syndrome; and transient cerebral ischemia. Orthologous to human TFPI (tissue factor pathway inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 279.1), Lung (RPKM 156.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q24
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (89939862..89989253, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (69533156..69582547, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (71852738..71902127, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486293 Neighboring gene calcitonin receptor like receptor Neighboring gene uncharacterized LOC134486403 Neighboring gene uncharacterized LOC134486404 Neighboring gene uncharacterized LOC108350412

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Effect of nitric oxide deficiency on tissue-type plasminogen activator expression in the umbilical cord in a pregnancy-induced hypertension rat model. Mukai Y, et al. Pregnancy Hypertens, 2012 Jan. PMID 26104991
  2. Tissue factor pathway inhibitor in activated prothrombin complex concentrates (aPCC) moderates the effectiveness of therapy in some severe hemophilia A patients with inhibitor. Ogiwara K, et al. Int J Hematol, 2014. PMID 24687919
  3. Drug-drug interaction of the anti-TFPI aptamer BAX499 and factor VIII: studies of spatial dynamics of fibrin clot formation in hemophilia A. Parunov LA, et al. Thromb Res, 2014 Jan. PMID 24263002
  4. Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation. Rancourt RC, et al. Toxicol Appl Pharmacol, 2013 Oct 1. PMID 23727623, Free PMC Article
  5. TFPI resistance related to inherited or acquired protein S deficiency. Tardy-Poncet B, et al. Thromb Res, 2012 Dec. PMID 23079294

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Intersection of regulatory pathways controlling hemostasis and hemochorial placentation.
    Title: Intersection of regulatory pathways controlling hemostasis and hemochorial placentation.
  2. Treatment with irbesartan plus carvedilol reduced the expression of TF and TFPI mRNA and protein after myocardial infarction in rats.
    Title: Combined effects of irbesartan and carvedilol on expression of tissue factor and tissue factor pathway inhibitor in rats after myocardial infarction.
  3. analysis of tissue factor changes and the effects of tissue factor pathway inhibitor on transient focal cerebral ischemia in rats
    Title: Changes in tissue factor and the effects of tissue factor pathway inhibitor on transient focal cerebral ischemia in rats.
  4. The results demonstrated that overexpression of TFPI gene might induce VSMC apoptosis in vitro through the mitochondrial pathway; meanwhile, IAP-1 expression is decreased.
    Title: Adenovirus-mediated gene transfer of tissue factor pathway inhibitor induces apoptosis in vascular smooth muscle cells.
  5. The expression of tissue factor and tissue factor pathway inhibitor in aortic smooth muscle cells is up-regulated in synthetic compared to contractile phenotype.
    Title: The expression of tissue factor and tissue factor pathway inhibitor in aortic smooth muscle cells is up-regulated in synthetic compared to contractile phenotype.
  6. TFPI expression is induced in cardiomyocytes, but not in endothelial cells, by IL-1beta.
    Title: Production of tissue factor pathway inhibitor in cardiomyocytes and its upregulation by interleukin-1.
  7. This is the first report showing that direct inhibition of TF-mediated coagulation activation abrogates bleomycin-induced pulmonary fibrosis.
    Title: Intratracheal gene transfer of tissue factor pathway inhibitor attenuates pulmonary fibrosis.
  8. Rapid atrial pacing acutely downregulated the gene expression of thrombomodulin and TFPI in rat atrial endocardium, thereby inducing local coagulation imbalance on the internal surface of the atrial cavity
    Title: Thrombomodulin and tissue factor pathway inhibitor in endocardium of rapidly paced rat atria.
  9. TFPI levels decreased significantly at 24 hours in burn, septic injury, and burn+septic injury groups, followed by incomplete rebound recovery at 72 hours
    Title: Tissue factor pathway inhibitor and thrombin activatable fibrinolytic inhibitor plasma levels following burn and septic injuries in rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to steroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in caveola ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tissue factor pathway inhibitor
Names
EPI
LACI
extrinsic pathway inhibitor
lipoprotein-associated coagulation inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177321.1 → NP_001170792.1  tissue factor pathway inhibitor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001170792.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC087020
    UniProtKB/TrEMBL
    A0A8I5Y6C8, Q5PQU8
    Related
    ENSRNOP00000054493.2, ENSRNOT00000057685.5
    Conserved Domains (1) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

  2. NM_017200.1 → NP_058896.1  tissue factor pathway inhibitor isoform 1 precursor

    See identical proteins and their annotated locations for NP_058896.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    D10926
    UniProtKB/Swiss-Prot
    Q02445
    UniProtKB/TrEMBL
    A0A8L2Q2B4, A6HMQ1
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:221 → 272
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    89939862..89989253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761981.4 → XP_008760203.1  tissue factor pathway inhibitor isoform X1

    See identical proteins and their annotated locations for XP_008760203.1

    UniProtKB/TrEMBL
    A0A8L2Q2B4
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:225 → 276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  2. XM_063283202.1 → XP_063139272.1  tissue factor pathway inhibitor isoform X2

    UniProtKB/Swiss-Prot
    Q02445
    UniProtKB/TrEMBL
    A6HMQ1

  3. XM_039104441.2 → XP_038960369.1  tissue factor pathway inhibitor isoform X2

    UniProtKB/Swiss-Prot
    Q02445
    UniProtKB/TrEMBL
    A0A8L2Q2B4, A6HMQ1
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:221 → 272
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  4. XM_063283203.1 → XP_063139273.1  tissue factor pathway inhibitor isoform X2

    UniProtKB/Swiss-Prot
    Q02445
    UniProtKB/TrEMBL
    A6HMQ1

  5. XM_008761982.2 → XP_008760204.1  tissue factor pathway inhibitor isoform X1

    See identical proteins and their annotated locations for XP_008760204.1

    UniProtKB/TrEMBL
    A0A8L2Q2B4
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:225 → 276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  6. XM_008761980.4 → XP_008760202.1  tissue factor pathway inhibitor isoform X1

    See identical proteins and their annotated locations for XP_008760202.1

    UniProtKB/TrEMBL
    A0A8L2Q2B4
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:225 → 276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  7. XM_006234440.5 → XP_006234502.1  tissue factor pathway inhibitor isoform X2

    See identical proteins and their annotated locations for XP_006234502.1

    UniProtKB/Swiss-Prot
    Q02445
    UniProtKB/TrEMBL
    A0A8L2Q2B4, A6HMQ1
    Related
    ENSRNOP00000078992.1
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:221 → 272
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  8. XM_006234441.4 → XP_006234503.1  tissue factor pathway inhibitor isoform X2

    See identical proteins and their annotated locations for XP_006234503.1

    UniProtKB/Swiss-Prot
    Q02445
    UniProtKB/TrEMBL
    A0A8L2Q2B4, A6HMQ1
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:221 → 272
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  9. XM_008761983.4 → XP_008760205.1  tissue factor pathway inhibitor isoform X1

    See identical proteins and their annotated locations for XP_008760205.1

    UniProtKB/TrEMBL
    A0A8L2Q2B4
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:225 → 276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  10. XM_008761984.4 → XP_008760206.1  tissue factor pathway inhibitor isoform X1

    See identical proteins and their annotated locations for XP_008760206.1

    UniProtKB/TrEMBL
    A0A8L2Q2B4
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:225 → 276
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  11. XM_006234444.4 → XP_006234506.1  tissue factor pathway inhibitor isoform X2

    See identical proteins and their annotated locations for XP_006234506.1

    UniProtKB/Swiss-Prot
    Q02445
    UniProtKB/TrEMBL
    A0A8L2Q2B4, A6HMQ1
    Conserved Domains (2) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:221 → 272
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  12. XM_063283204.1 → XP_063139274.1  tissue factor pathway inhibitor isoform X4

    UniProtKB/TrEMBL
    Q5PQU8

  13. XM_063283208.1 → XP_063139278.1  tissue factor pathway inhibitor isoform X6

  14. XM_063283206.1 → XP_063139276.1  tissue factor pathway inhibitor isoform X4

    UniProtKB/TrEMBL
    Q5PQU8

  15. XM_063283210.1 → XP_063139280.1  tissue factor pathway inhibitor isoform X6

  16. XM_039104442.2 → XP_038960370.1  tissue factor pathway inhibitor isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y6C8
    Conserved Domains (1) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

  17. XM_008761986.4 → XP_008760208.1  tissue factor pathway inhibitor isoform X5

    UniProtKB/TrEMBL
    A0A8I5Y6C8
    Conserved Domains (1) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

  18. XM_008761985.3 → XP_008760207.1  tissue factor pathway inhibitor isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y6C8
    Conserved Domains (1) summary
    cd00109
    Location:122 → 174
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

  19. XM_063283205.1 → XP_063139275.1  tissue factor pathway inhibitor isoform X4

    UniProtKB/TrEMBL
    Q5PQU8

  20. XM_063283207.1 → XP_063139277.1  tissue factor pathway inhibitor isoform X4

    UniProtKB/TrEMBL
    Q5PQU8

  21. XM_063283209.1 → XP_063139279.1  tissue factor pathway inhibitor isoform X6

  22. XM_063283211.1 → XP_063139281.1  tissue factor pathway inhibitor isoform X6

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02445.1 GenPept UniProtKB/Swiss-Prot:Q02445

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