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Agpat3 1-acylglycerol-3-phosphate O-acyltransferase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294324, updated on 11-Apr-2024

Summary

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Official Symbol
Agpat3provided by RGD
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 3provided by RGD
Primary source
RGD:1305787
See related
Ensembl:ENSRNOG00000001205 AllianceGenome:RGD:1305787
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Predicted to be active in endoplasmic reticulum. Orthologous to human AGPAT3 (1-acylglycerol-3-phosphate O-acyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 219.3), Brain (RPKM 213.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
20p12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (10330650..10415026)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (10330960..10415358)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (11060584..11144806)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ribosomal RNA processing 1 Neighboring gene uncharacterized LOC120098853 Neighboring gene trafficking protein particle complex subunit 10 Neighboring gene PWP2, small subunit processome component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of mouse lysophosphatidic acid acyltransferase 3: an enzyme with dual functions in the testis. Yuki K, et al. J Lipid Res, 2009 May. PMID 19114731, Free PMC Article
  2. Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria. Prasad SS, et al. J Lipid Res, 2011 Mar. PMID 21173190, Free PMC Article
  3. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. Hu YH, et al. BMC Genomics, 2006 Jun 16. PMID 16780588, Free PMC Article
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables lysophosphatidic acid acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
NP_001099848.1
XP_006256305.1
XP_038954480.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106378.1 → NP_001099848.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

    See identical proteins and their annotated locations for NP_001099848.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473988
    UniProtKB/TrEMBL
    A6JK33, B0BNL8, G3V648
    Related
    ENSRNOP00000001602.5, ENSRNOT00000001602.6
    Conserved Domains (1) summary
    PLN02380
    Location:12 → 325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    10330650..10415026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256243.5 → XP_006256305.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    See identical proteins and their annotated locations for XP_006256305.1

    UniProtKB/TrEMBL
    A6JK33, B0BNL8, G3V648
    Conserved Domains (1) summary
    PLN02380
    Location:12 → 325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

  2. XM_039098552.2 → XP_038954480.1  1-acyl-sn-glycerol-3-phosphate acyltransferase gamma isoform X1

    UniProtKB/TrEMBL
    A6JK33, B0BNL8, G3V648
    Conserved Domains (1) summary
    PLN02380
    Location:12 → 325
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
Nucleotide Protein Strain
Heading Accession and Version

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