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Gtf2h4 general transcription factor 2H subunit 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294236, updated on 5-Mar-2024

Summary

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Official Symbol
Gtf2h4provided by RGD
Official Full Name
general transcription factor 2H subunit 4provided by RGD
Primary source
RGD:1303309
See related
AllianceGenome:RGD:1303309
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA polymerase II general transcription initiation factor activity and double-stranded DNA binding activity. Predicted to be involved in nucleotide-excision repair; phosphorylation of RNA polymerase II C-terminal domain; and transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be part of core TFIIH complex portion of holo TFIIH complex and transcription factor TFIID complex. Orthologous to human GTF2H4 (general transcription factor IIH subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Thymus (RPKM 44.7), Heart (RPKM 31.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
20p12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3076110..3081805)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3071328..3076990)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3582688..3588373)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483849 Neighboring gene hypothetical LOC100310783 Neighboring gene discoidin domain receptor tyrosine kinase 1 Neighboring gene uncharacterized LOC134483850 Neighboring gene valyl-tRNA synthetase 2, mitochondrial Neighboring gene surfactant associated 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH. Marinoni JC, et al. EMBO J, 1997 Mar 3. PMID 9118947, Free PMC Article
  2. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. Egly JM, et al. DNA Repair (Amst), 2011 Jul 15. PMID 21592869
  3. Near-atomic resolution visualization of human transcription promoter opening. He Y, et al. Nature, 2016 May 19. PMID 27193682, Free PMC Article
  4. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. Kershnar E, et al. J Biol Chem, 1998 Dec 18. PMID 9852112
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC156549

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of core TFIIH complex portion of holo TFIIH complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIH core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
general transcription factor IIH subunit 4
Names
TFIIH transcription/DNA repair factor p52 subunit
general transcription factor II H, polypeptide 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212501.2 → NP_997666.1  general transcription factor IIH subunit 4

    See identical proteins and their annotated locations for NP_997666.1

    Status: VALIDATED

    Source sequence(s)
    BC127469, CK472761
    UniProtKB/TrEMBL
    Q6MG20
    Conserved Domains (1) summary
    TIGR00625
    Location:19 → 461
    tfb2; Transcription factor tfb2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    3076110..3081805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278998.1 → XP_063135068.1  general transcription factor IIH subunit 4 isoform X1

  2. XM_063278999.1 → XP_063135069.1  general transcription factor IIH subunit 4 isoform X1

RNA

  1. XR_010060632.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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