U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Aadat aminoadipate aminotransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 29416, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Aadatprovided by RGD
Official Full Name
aminoadipate aminotransferaseprovided by RGD
Primary source
RGD:2948
See related
Ensembl:ENSRNOG00000011861 AllianceGenome:RGD:2948
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kat2
Summary
Enables kynurenine-oxoglutarate transaminase activity. Predicted to be involved in 2-oxoglutarate metabolic process; glutamate metabolic process; and kynurenine metabolic process. Predicted to be located in mitochondrion. Orthologous to human AADAT (aminoadipate aminotransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 1947.0) and Liver (RPKM 376.0) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
16p12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (34520236..34566388, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (29509392..29544332, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (32832001..32868680, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A, pseudogene 13 Neighboring gene microfibril associated protein 3 like Neighboring gene uncharacterized LOC134478862 Neighboring gene ribosomal protein L18, pseudogene 1 Neighboring gene solute carrier family 25 member 13, pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry. Guidetti P, et al. Glia, 2007 Jan 1. PMID 17024659
  2. Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney. Buchli R, et al. J Biol Chem, 1995 Dec 8. PMID 7493966
  3. Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II. Han Q, et al. Biosci Rep, 2008 Aug. PMID 18620547, Free PMC Article
  4. Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia. Rossi F, et al. J Biol Chem, 2008 Feb 8. PMID 18056996
  5. Crystal structure of human kynurenine aminotransferase II. Han Q, et al. J Biol Chem, 2008 Feb 8. PMID 18056995

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We found specific staining of KAT II-positive astrocyte-like cells throughout the adult rat brain. The presence of KAT II in astrocytes was confirmed by double fluorescence immunostaining with an antibody against the astrocyte-specific marker GFAP.
    Title: Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry.
  2. neuronal culture showed positive immunostaining for both kynurenic acid aminotransferase (KAT) isoforms I and II
    Title: Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in cultured cerebral cortical neurons.
  3. identification of presence in the permanent immature rat oligodendrocyte cell line OLN-93
    Title: Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in oligodendrocyte cell line (OLN-93).
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2-aminoadipate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-aminoadipate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-aminoadipate transaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables 2-aminoadipate transaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycine:2-oxoglutarate aminotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycine:2-oxoglutarate aminotransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycine:2-oxoglutarate aminotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables kynurenine-glyoxylate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kynurenine-glyoxylate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables kynurenine-glyoxylate transaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables kynurenine-glyoxylate transaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables kynurenine-oxoglutarate transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kynurenine-oxoglutarate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kynurenine-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables kynurenine-oxoglutarate transaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables kynurenine-oxoglutarate transaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables methionine-glyoxylate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables methionine-glyoxylate transaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables methionine-glyoxylate transaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 2-oxoglutarate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in 2-oxoglutarate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in L-kynurenine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-lysine catabolic process to acetyl-CoA via saccharopine IEA
Inferred from Electronic Annotation
more info
  
involved_in alpha-amino acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in kynurenine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in kynurenine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Names
2-aminoadipate aminotransferase
2-aminoadipate transaminase
KAT/AadAT
alpha-aminoadipate aminotransferase
glycine transaminase AADAT
kynurenine aminotransferase 2
kynurenine aminotransferase II
kynurenine--glyoxylate transaminase AADAT
kynurenine--oxoglutarate aminotransferase II
kynurenine--oxoglutarate transaminase 2
kynurenine--oxoglutarate transaminase II
methionine--glyoxylate transaminase AADAT
NP_058889.1
XP_063131340.1
XP_063131341.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017193.1 → NP_058889.1  kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

    See identical proteins and their annotated locations for NP_058889.1

    Status: PROVISIONAL

    Source sequence(s)
    Z50144
    UniProtKB/Swiss-Prot
    Q64602
    UniProtKB/TrEMBL
    A0A8L2Q812, A6KIT5
    Related
    ENSRNOP00000015974.4, ENSRNOT00000015974.6
    Conserved Domains (1) summary
    COG1167
    Location:20 → 423
    ARO8; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    34520236..34566388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275271.1 → XP_063131341.1  kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform X2

  2. XM_063275270.1 → XP_063131340.1  kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64602.1 GenPept UniProtKB/Swiss-Prot:Q64602

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous