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Pprc1 PPARG related coactivator 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 294007, updated on 5-Mar-2024

Summary

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Official Symbol
Pprc1provided by RGD
Official Full Name
PPARG related coactivator 1provided by RGD
Primary source
RGD:1309688
See related
Ensembl:ENSRNOG00000018561 AllianceGenome:RGD:1309688
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in positive regulation of DNA-binding transcription factor activity and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human PPRC1 (PPARG related coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 57.0), Adrenal (RPKM 43.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q54
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (254851136..254867570)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (244901985..244918587)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (265809892..265826319)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 Neighboring gene LIM domain binding 1 Neighboring gene LIM domain binding 1 like Neighboring gene nucleolar and coiled-body phosphoprotein 1 Neighboring gene ELOVL fatty acid elongase 3 Neighboring gene paired-like homeodomain 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peroxisome proliferator-activated receptor gamma coactivator-related protein 1
Names
peroxisome proliferative activated receptor, gamma, coactivator-related 1
peroxisome proliferator-activated receptor gamma, coactivator-related 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106363.1 → NP_001099833.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1

    See identical proteins and their annotated locations for NP_001099833.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473986
    UniProtKB/TrEMBL
    A6JHK7
    Conserved Domains (1) summary
    cd12624
    Location:1515 → 1605
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    254851136..254867570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589040.3 → XP_017444529.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X12

    UniProtKB/TrEMBL
    A6JHK8

  2. XM_063287211.1 → XP_063143281.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X13

  3. XM_063287217.1 → XP_063143287.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X14

  4. XM_063287219.1 → XP_063143289.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X15

  5. XM_063287221.1 → XP_063143291.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X16

  6. XM_006231454.5 → XP_006231516.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X4

    Conserved Domains (1) summary
    cd12624
    Location:1514 → 1604
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  7. XM_006231455.5 → XP_006231517.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6

    Conserved Domains (1) summary
    cd12624
    Location:1513 → 1603
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  8. XM_039109074.2 → XP_038965002.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X11

    Conserved Domains (2) summary
    PHA03247
    Location:597 → 1082
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:1482 → 1572
    RRM_PRC; RNA recognition motif (RRM) found in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  9. XM_006231451.5 → XP_006231513.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X1

    UniProtKB/TrEMBL
    D3ZRG8
    Related
    ENSRNOP00000025222.8
    Conserved Domains (1) summary
    cd12624
    Location:1516 → 1606
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  10. XM_006231452.5 → XP_006231514.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X2

    Conserved Domains (1) summary
    cd12624
    Location:1515 → 1605
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  11. XM_063287192.1 → XP_063143262.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X5

  12. XM_063287198.1 → XP_063143268.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

  13. XM_063287201.1 → XP_063143271.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X8

  14. XM_063287203.1 → XP_063143273.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X9

  15. XM_006231453.4 → XP_006231515.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X3

    UniProtKB/TrEMBL
    D3ZRG8
    Conserved Domains (1) summary
    cd12624
    Location:1514 → 1604
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  16. XM_006231456.5 → XP_006231518.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X10

    Conserved Domains (1) summary
    cd12624
    Location:1508 → 1598
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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