Esrra estrogen related receptor, alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Esrraprovided by RGD
Official Full Name: estrogen related receptor, alphaprovided by RGD
Primary source: RGD:1583866
See related: Ensembl:ENSRNOG00000021139 AllianceGenome:RGD:1583866
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Errra; ERRalpha
Summary: Enables sequence-specific DNA binding activity. Involved in several processes, including regulation of osteoblast differentiation; regulation of osteoclast differentiation; and response to estradiol. Located in nucleus. Orthologous to human ESRRA (estrogen related receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 313.6), Muscle (RPKM 294.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (213533309..213543432, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (204104100..204114182, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (222168729..222178842, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ERRalpha protects against sepsis-induced acute lung injury in rats.
Title: ERRα protects against sepsis-induced acute lung injury in rats.
Molecular Mediators of Estrogen Reduction-induced Otolith Shedding.
Title: Molecular Mediators of Estrogen Reduction-induced Otolith Shedding.
ERRalpha-mediated protection of mitochondrial bioenergetics might be the likely candidate required for lung adaptation to hypobaric hypoxia
Title: Adaptability to hypobaric hypoxia is facilitated through mitochondrial bioenergetics: an in vivo study.
Methyl donor deficiency impairs fatty acid oxidation through PGC-1alpha hypomethylation and decreased ER-alpha, ERR-alpha, and HNF-4alpha in the rat liver.
Title: Methyl donor deficiency impairs fatty acid oxidation through PGC-1α hypomethylation and decreased ER-α, ERR-α, and HNF-4α in the rat liver.
examined the interaction of estrogen receptor-alpha (ERalpha), estrogen receptor-related receptor-alpha (ERRalpha), and stone matrix protein osteopontin (OPN) in a hyperoxaluric model
Title: The Interaction between female sex hormone receptors and osteopontin in a rat hyperoxaluric model.
ERRalpha is an important regulator of glucose metabolism.
Title: PGC-1alpha coactivates estrogen-related receptor-alpha to induce the expression of glucokinase.
DHEA production is regulated by PGC-1alpha, ERRalpha, and HNF4alpha
Title: Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha.
Role for ERRalpha in the formation and maintenance of cartilage.
Title: The orphan nuclear estrogen receptor-related receptor-alpha regulates cartilage formation in vitro: implication of Sox9.
ERalpha and ERbeta mRNA expressions are differentially regulated in rat uterus. During spontaneous labor ERalpha may play more prominent role than ERbeta in mediating estrogen action in tinduction of uterine oxytocin receptor mRNA before labor.
Title: Differential regulation of estrogen receptor alpha and beta mRNAs in the rat uterus during pregnancy and labor: possible involvement of estrogen receptors in oxytocin receptor regulation.
Estrogen-related receptor alpha binds to the hepatic pyruvate dehydrogenase kinase (PDK) 4 promoter and stimulates PDK4 expression.
Title: Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BARC0081 (e-PCR)
- UniSTS:277893

Esrra (e-PCR), detects polymorphism
- UniSTS:496007

BE121120 (e-PCR)
- UniSTS:248023

RH142172 (e-PCR)
- UniSTS:231423

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables steroid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular steroid hormone receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: steroid hormone receptor ERR1

Names: ERR-alpha; nuclear receptor subfamily 3 group B member 1; orphan nuclear receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008511.2 → NP_001008511.2 steroid hormone receptor ERR1

See identical proteins and their annotated locations for NP_001008511.2

Status: VALIDATED

Source sequence(s)

AY280663, BC104701

UniProtKB/Swiss-Prot

Q3MHT1, Q5QJV7

UniProtKB/TrEMBL

A0A0G2JWR7, A6HZJ4

Related

ENSRNOP00000028697.4, ENSRNOT00000028697.6

Conserved Domains (2) summary

cd06946
Location:196 → 419

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cd07170
Location:73 → 168

NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

213533309..213543432 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108526.2 → XP_038964454.1 steroid hormone receptor ERR1 isoform X1

Conserved Domains (2) summary

cd06946
Location:53 → 276

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cl02596
Location:1 → 25

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
XM_039108523.2 → XP_038964451.1 steroid hormone receptor ERR1 isoform X1

Conserved Domains (2) summary

cd06946
Location:53 → 276

NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

cl02596
Location:1 → 25

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
XM_063286879.1 → XP_063142949.1 steroid hormone receptor ERR1 isoform X1
XM_063286880.1 → XP_063142950.1 steroid hormone receptor ERR1 isoform X2