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Chkb choline kinase beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 29367, updated on 11-Apr-2024

Summary

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Official Symbol
Chkbprovided by RGD
Official Full Name
choline kinase betaprovided by RGD
Primary source
RGD:61826
See related
Ensembl:ENSRNOG00000011404 AllianceGenome:RGD:61826
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Chkl; Chetk
Summary
Enables choline kinase activity. Predicted to be involved in CDP-choline pathway and phosphatidylethanolamine biosynthetic process. Predicted to act upstream of or within muscle organ development. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in intellectual disability; megaconial type congenital muscular dystrophy; muscular dystrophy; narcolepsy; and recurrent hypersomnia. Orthologous to human CHKB (choline kinase beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 120.4), Thymus (RPKM 109.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q34
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (122380592..122385102, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (120500960..120504359, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (130404818..130408813, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene synaptonemal complex central element protein 3 Neighboring gene carnitine palmitoyltransferase 1B Neighboring gene uncharacterized LOC134479955 Neighboring gene uncharacterized LOC134479956 Neighboring gene mitogen-activated protein kinase 8 interacting protein 2 Neighboring gene arylsulfatase A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Complete purification of choline kinase from rat kidney and preparation of rabbit antibody against rat kidney choline kinase. Ishidate K, et al. J Biol Chem, 1984 Dec 10. PMID 6094572
  2. Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy. Mitsuhashi S, et al. Hum Mol Genet, 2011 Oct 1. PMID 21750112, Free PMC Article
  3. Complementary DNA sequence for a 42 kDa rat kidney choline/ethanolamine kinase. Aoyama C, et al. Biochim Biophys Acta, 1998 Feb 5. PMID 9487136
  4. A congenital muscular dystrophy with mitochondrial structural abnormalities caused by defective de novo phosphatidylcholine biosynthesis. Mitsuhashi S, et al. Am J Hum Genet, 2011 Jun 10. PMID 21665002, Free PMC Article
  5. Expression of brain-type creatine kinase and ubiquitous mitochondrial creatine kinase in the fetal rat brain: evidence for a nuclear energy shuttle. Chen L, et al. J Comp Neurol, 1995 Dec 18. PMID 8847407

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables choline kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables choline kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables choline kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables choline kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ethanolamine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ethanolamine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CDP-choline pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within muscle organ development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphatidylcholine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylethanolamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylethanolamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylethanolamine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
choline/ethanolamine kinase
Names
CK
CKB
CKEKB
EK
choline/ethanolamine kinase beta
ethanolamine kinase
NP_058873.1
XP_006242243.2
XP_038934502.1
XP_038934504.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017177.1 → NP_058873.1  choline/ethanolamine kinase

    See identical proteins and their annotated locations for NP_058873.1

    Status: PROVISIONAL

    Source sequence(s)
    AB006607
    UniProtKB/Swiss-Prot
    O54783
    UniProtKB/TrEMBL
    A6K7M9
    Related
    ENSRNOP00000015374.1, ENSRNOT00000015374.3
    Conserved Domains (1) summary
    cd05156
    Location:73 → 385
    ChoK_euk; Euykaryotic Choline Kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    122380592..122385102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242181.5 → XP_006242243.2  choline/ethanolamine kinase isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:162 → 399
    PKc_like; Protein Kinases, catalytic domain

  2. XM_039078574.2 → XP_038934502.1  choline/ethanolamine kinase isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:69 → 306
    PKc_like; Protein Kinases, catalytic domain

  3. XM_039078576.2 → XP_038934504.1  choline/ethanolamine kinase isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:24 → 261
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_010052945.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54783.3 GenPept UniProtKB/Swiss-Prot:O54783

Gene LinkOut

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