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Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293652, updated on 11-Apr-2024

Summary

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Official Symbol
Ndufs8provided by RGD
Official Full Name
NADH:ubiquinone oxidoreductase core subunit S8provided by RGD
Primary source
RGD:1309436
See related
Ensembl:ENSRNOG00000017446 AllianceGenome:RGD:1309436
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to contribute to NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; and response to oxidative stress. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 2. Orthologous to human NDUFS8 (NADH:ubiquinone oxidoreductase core subunit S8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 1099.0), Muscle (RPKM 682.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q43
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210569823..210573707, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201140585..201144573, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219141289..219144610, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene choline kinase alpha Neighboring gene T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 Neighboring gene aldehyde dehydrogenase 3 family, member B1 Neighboring gene unc-93 homolog B1, TLR signaling regulator Neighboring gene aldehyde dehydrogenase 3 family, member B3 Neighboring gene aldehyde dehydrogenase 3 family, member B3-like, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Late-onset Leigh syndrome in a patient with mitochondrial complex I NDUFS8 mutations. Procaccio V, et al. Neurology, 2004 May 25. PMID 15159508, Free PMC Article
  2. The first nuclear-encoded complex I mutation in a patient with Leigh syndrome. Loeffen J, et al. Am J Hum Genet, 1998 Dec. PMID 9837812, Free PMC Article
  3. Genomic structure of the human NDUFS8 gene coding for the iron-sulfur TYKY subunit of the mitochondrial NADH:ubiquinone oxidoreductase. de Sury R, et al. Gene, 1998 Jul 17. PMID 9666055
  4. Mutations in the complex I NDUFS2 gene of patients with cardiomyopathy and encephalomyopathy. Loeffen J, et al. Ann Neurol, 2001 Feb. PMID 11220739
  5. Differences in assembly or stability of complex I and other mitochondrial OXPHOS complexes in inherited complex I deficiency. Ugalde C, et al. Hum Mol Genet, 2004 Mar 15. PMID 14749350

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to NADH dehydrogenase (ubiquinone) activity ISO
Inferred from Sequence Orthology
more info
  
enables NADH dehydrogenase (ubiquinone) activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to NADH dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to NADH dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mitochondrial electron transport, NADH to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, NADH to ubiquinone ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Names
NADH dehydrogenase (ubiquinone) Fe-S protein 8
NP_001099792.1
XP_006230793.1
XP_017444503.1
XP_038964139.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106322.2 → NP_001099792.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

    See identical proteins and their annotated locations for NP_001099792.1

    Status: PROVISIONAL

    Source sequence(s)
    BC158791
    UniProtKB/TrEMBL
    B0BNE6, F7FGW7
    Conserved Domains (1) summary
    PRK05888
    Location:57 → 212
    PRK05888; NADH-quinone oxidoreductase subunit NuoI

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    210569823..210573707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230731.3 → XP_006230793.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006230793.1

    UniProtKB/TrEMBL
    B0BNE6, F7FGW7
    Conserved Domains (1) summary
    PRK05888
    Location:57 → 212
    PRK05888; NADH-quinone oxidoreductase subunit NuoI

  2. XM_039108211.2 → XP_038964139.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1

    UniProtKB/TrEMBL
    B0BNE6, F7FGW7
    Conserved Domains (1) summary
    PRK05888
    Location:57 → 212
    PRK05888; NADH-quinone oxidoreductase subunit NuoI

  3. XM_017589014.3 → XP_017444503.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1

    UniProtKB/TrEMBL
    B0BNE6, F7FGW7
    Related
    ENSRNOP00000023526.5
    Conserved Domains (1) summary
    PRK05888
    Location:57 → 212
    PRK05888; NADH-quinone oxidoreductase subunit NuoI
Nucleotide Protein Strain
Heading Accession and Version

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