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Irf7 interferon regulatory factor 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 293624, updated on 5-Mar-2024

Summary

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Official Symbol
Irf7provided by RGD
Official Full Name
interferon regulatory factor 7provided by RGD
Primary source
RGD:1307828
See related
Ensembl:ENSRNOG00000017414 AllianceGenome:RGD:1307828
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of type I interferon production; and regulation of toll-like receptor signaling pathway. Predicted to act upstream of or within immunoglobulin mediated immune response; positive regulation of type I interferon production; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 39. Orthologous to human IRF7 (interferon regulatory factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 506.0), Lung (RPKM 159.4) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q41
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205796956..205800543, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196367380..196370943, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214249388..214252909, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553043 Neighboring gene microRNA 3574 Neighboring gene microRNA 210 Neighboring gene PHD and ring finger domains 1 Neighboring gene cadherin-related family member 5 Neighboring gene secretin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interferon regulatory factor 7 inhibits rat vascular smooth muscle cell proliferation and inflammation in monocrotaline-induced pulmonary hypertension. Deng Y, et al. Life Sci, 2021 Jan 1. PMID 33152351
  2. Peripubertal viral-like challenge and social isolation mediate overlapping but distinct effects on behaviour and brain interferon regulatory factor 7 expression in the adult Wistar rat. Lukasz B, et al. Brain Behav Immun, 2013 Jan. PMID 23036922
  3. IRF-7: new role in the regulation of genes involved in adaptive immunity. Sgarbanti M, et al. Ann N Y Acad Sci, 2007 Jan. PMID 17404045
  4. Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. Caillaud A, et al. J Biol Chem, 2002 Dec 20. PMID 12374802
  5. The infected cell protein 0 encoded by bovine herpesvirus 1 (bICP0) associates with interferon regulatory factor 7 and consequently inhibits beta interferon promoter activity. Saira K, et al. J Virol, 2009 Apr. PMID 19176627, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury.
    Title: Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury.
  2. Interferon regulatory factor 7 inhibits rat vascular smooth muscle cell proliferation and inflammation in monocrotaline-induced pulmonary hypertension.
    Title: Interferon regulatory factor 7 inhibits rat vascular smooth muscle cell proliferation and inflammation in monocrotaline-induced pulmonary hypertension.
  3. Isolation rearing and a peripubertal immune challenge increase Irf7 expression in the rat hippocampal gyrus.
    Title: Peripubertal viral-like challenge and social isolation mediate overlapping but distinct effects on behaviour and brain interferon regulatory factor 7 expression in the adult Wistar rat.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC125013

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within immunoglobulin mediated immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of MyD88-dependent toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of MyD88-independent toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of adaptive immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interferon regulatory factor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033691.1 → NP_001028863.1  interferon regulatory factor 7

    See identical proteins and their annotated locations for NP_001028863.1

    Status: PROVISIONAL

    Source sequence(s)
    BC104686
    UniProtKB/TrEMBL
    F7FGY2, Q3SWU2
    Conserved Domains (2) summary
    pfam00605
    Location:11 → 121
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:240 → 418
    IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    205796956..205800543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230540.3 → XP_006230602.1  interferon regulatory factor 7 isoform X1

    See identical proteins and their annotated locations for XP_006230602.1

    UniProtKB/TrEMBL
    F7FGY2, Q3SWU2
    Related
    ENSRNOP00000023504.6
    Conserved Domains (2) summary
    pfam00605
    Location:11 → 121
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:240 → 418
    IRF-3; Interferon-regulatory factor 3

  2. XM_006230541.2 → XP_006230603.1  interferon regulatory factor 7 isoform X2

    Conserved Domains (2) summary
    pfam00605
    Location:11 → 121
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:208 → 386
    IRF-3; Interferon-regulatory factor 3
Nucleotide Protein Strain
Heading Accession and Version

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