Hras HRas proto-oncogene, GTPase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hrasprovided by RGD
Official Full Name: HRas proto-oncogene, GTPaseprovided by RGD
Primary source: RGD:2827
See related: Ensembl:ENSRNOG00000016611 AllianceGenome:RGD:2827
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: HRAS1; c-H-ras
Summary: Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular senescence; positive regulation of DNA replication; and positive regulation of ERK1 and ERK2 cascade. Acts upstream of or within positive regulation of Ras protein signal transduction. Located in intracellular membrane-bounded organelle and plasma membrane. Used to study diabetic retinopathy and liver carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 343.7), Brain (RPKM 196.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (205712625..205729406, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (196290127..196299823, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (214178404..214181841, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Together, these results suggest a novel mechanism regulating PATZ1 expression based on the upregulation of miR-29b expression induced by Ras oncogene.
Title: PATZ1 is a target of miR-29b that is induced by Ha-Ras oncogene in rat thyroid cells.
H-ras isoform mediates protection against pressure overload-induced cardiac dysfunction in part through activation of AKT/PI3K signaling pathway.
Title: H-Ras Isoform Mediates Protection Against Pressure Overload-Induced Cardiac Dysfunction in Part Through Activation of AKT.
Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers.
Title: Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers.
H-Ras mediates the inhibitory effect of epidermal growth factor on the epithelial Na+ channel
Title: H-Ras mediates the inhibitory effect of epidermal growth factor on the epithelial Na+ channel.
Ras, ERK, and Akt are key effectors in the glucocorticoid-induced differentiation of growth hormone-secreting cells.
Title: Role of Ras, ERK, and Akt in glucocorticoid-induced differentiation of embryonic rat somatotropes in vitro.
It has been found that NaBut reduces proliferation rate of ERasBcl (E1A, cHa-ras and bcl-2 ) cells significantly weaker than of ERas transformed cells
Title: [Antiapoptotic gene bcl-2 prevents cellular senescence program reactivation induced by histone deacetylase inhibitor sodium butyrate in E1A and cHa-ras transformed rat fibroblasts].
Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases.
Title: Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases.
Data indicate that numerous proteins that are up-regulated in H-ras(G12V) transgenic rat pancreatic ductal adenocarcinoma (PDAC) are also up-regulated in human PDAC; therefore, this rat model can be used for diagnostic biomarkers for this disease.
Title: Twenty-one proteins up-regulated in human H-ras oncogene transgenic rat pancreas cancers are up-regulated in human pancreas cancer.
Fe(2+)-generated O(2) mediates p21(ras) and TAK1 activation via PTP inhibition and Lys(63)-polyUb of TRAF6 in caveosomes for proinflammatory M1 activation in hepatic macrophages
Title: Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation.
The proto-oncogenic H-Ras is directly involved in the promotion of muscle differentiation via PI3K and its downstream signaling pathways.
Title: Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94696 (e-PCR)
- UniSTS:119943

PMC86690P1 (e-PCR)
- UniSTS:273544

PMC112649P2 (e-PCR)
- UniSTS:270240

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Schwann cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T-helper 1 type immune response	ISO Inferred from Sequence Orthology more info
involved_in adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to gamma radiation	ISO Inferred from Sequence Orthology more info
involved_in cellular senescence	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular senescence	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in cellular senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to protozoan	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in myelination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oncogene-induced cell senescence	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to isolation stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of GTPase complex	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: GTPase HRas

Names: H-Ras-1; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma virus oncogene; p21ras; transforming protein p21

NP_001091711.1

EC 3.6.5.2

NP_001123913.1

EC 3.6.5.2

XP_006230597.3

EC 3.6.5.2

XP_017444497.1

EC 3.6.5.2

XP_038963859.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098241.1 → NP_001091711.1 GTPase HRas

See identical proteins and their annotated locations for NP_001091711.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC086608, BC099130

UniProtKB/Swiss-Prot

P20171, Q4KLL6, Q5RJJ8

UniProtKB/TrEMBL

A6HXQ6

Conserved Domains (1) summary

cd04138
Location:3 → 164

H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
NM_001130441.1 → NP_001123913.1 GTPase HRas

See identical proteins and their annotated locations for NP_001123913.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 3' UTR, compared to variant 2. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC086608, CO567790

UniProtKB/Swiss-Prot

P20171, Q4KLL6, Q5RJJ8

UniProtKB/TrEMBL

A6HXQ6

Conserved Domains (1) summary

cd04138
Location:3 → 164

H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

205712625..205729406 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107931.2 → XP_038963859.1 GTPase HRas isoform X1

UniProtKB/TrEMBL

A0A8L2QCK8, A0A8L2R1F7

Conserved Domains (1) summary

cd04138
Location:104 → 265

H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
XM_006230535.4 → XP_006230597.3 GTPase HRas isoform X1

UniProtKB/TrEMBL

A0A8L2QCK8, A0A8L2R1F7

Related

ENSRNOP00000069770.2, ENSRNOT00000079464.2

Conserved Domains (1) summary

cd04138
Location:104 → 265

H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
XM_017589008.3 → XP_017444497.1 GTPase HRas isoform X2

UniProtKB/TrEMBL

A0A8L2QIP9

Conserved Domains (1) summary

cd04138
Location:3 → 150

H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B