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Eif3f eukaryotic translation initiation factor 3, subunit F [ Rattus norvegicus (Norway rat) ]

Gene ID: 293427, updated on 5-Mar-2024

Summary

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Official Symbol
Eif3fprovided by RGD
Official Full Name
eukaryotic translation initiation factor 3, subunit Fprovided by RGD
Primary source
RGD:1306112
See related
Ensembl:ENSRNOG00000015221 AllianceGenome:RGD:1306112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Eif3s5
Summary
Predicted to enable identical protein binding activity; thiol-dependent deubiquitinase; and translation initiation factor binding activity. Predicted to contribute to translation initiation factor activity. Predicted to be involved in IRES-dependent viral translational initiation; protein deubiquitination; and translational initiation. Predicted to be part of eukaryotic translation initiation factor 3 complex, eIF3m. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human EIF3F (eukaryotic translation initiation factor 3 subunit F). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 547.4), Spleen (RPKM 533.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q33
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (172369062..172378043)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (162934220..162943204)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (173532826..173541806)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily A member 3C Neighboring gene NLR family, pyrin domain containing 10 Neighboring gene TUB bipartite transcription factor Neighboring gene high mobility group protein B1 pseudogene Neighboring gene RIC3 acetylcholine receptor chaperone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of variations of gene expression of visceral adipose and renal tissue in type 2 diabetic rats using cDNA representational difference analysis. Yang J, et al. Chin Med J (Engl), 2003 Apr. PMID 12875716
  2. The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation. Moretti J, et al. PLoS Biol, 2010 Nov 23. PMID 21124883, Free PMC Article
  3. Specific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs. Sizova DV, et al. J Virol, 1998 Jun. PMID 9573242, Free PMC Article
  4. The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. Zeng L, et al. J Biol Chem, 2013 Oct 18. PMID 24003236, Free PMC Article
  5. The scanning mechanism of eukaryotic translation initiation. Hinnebusch AG. Annu Rev Biochem, 2014. PMID 24499181

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal-dependent deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in IRES-dependent viral translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation initiation factor 3 complex, eIF3m IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex, eIF3m ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit F
Names
eukaryotic translation initiation factor 3, subunit 5 (epsilon)
NP_001264231.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277302.1 → NP_001264231.1  eukaryotic translation initiation factor 3 subunit F

    Status: VALIDATED

    Source sequence(s)
    FQ213714, FQ230130
    UniProtKB/TrEMBL
    D4AC36
    Related
    ENSRNOP00000021017.6, ENSRNOT00000021017.8
    Conserved Domains (1) summary
    cd08064
    Location:96 → 358
    MPN_eIF3f; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF3f

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    172369062..172378043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106292.1: Suppressed sequence

    Description
    NM_001106292.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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