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Cd46 CD46 molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 29333, updated on 3-Apr-2024

Summary

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Official Symbol
Cd46provided by RGD
Official Full Name
CD46 moleculeprovided by RGD
Primary source
RGD:3061
See related
Ensembl:ENSRNOG00000008193 AllianceGenome:RGD:3061
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mcp
Summary
Contributes to endopeptidase activity. Involved in positive regulation of proteolysis. Located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and inner acrosomal membrane. Biomarker of acute necrotizing pancreatitis. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; meningococcal meningitis; multiple sclerosis; and pre-eclampsia. Orthologous to human CD46 (CD46 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 28.9), Thymus (RPKM 26.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q27
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (109104122..109134903, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (106575586..106606325, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (113786525..113818741, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550527 Neighboring gene microRNA 3556b Neighboring gene microRNA 29b-2 Neighboring gene microRNA 29c Neighboring gene uncharacterized LOC108352604 Neighboring gene complement C3b/C4b receptor 1 like Neighboring gene complement C3d receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Whole blood gene expression profiles distinguish clinical phenotypes of venous thromboembolism. Lewis DA, et al. Thromb Res, 2015 Apr. PMID 25684211, Free PMC Article
  2. A CD46 transgenic mouse model for studying the histopathology of arthritis caused by subcutaneous infection with Streptococcus dysgalactiae subspecies equisimilis. Yoshida H, et al. J Med Microbiol, 2011 Dec. PMID 21852528
  3. Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. Salmon JE, et al. PLoS Med, 2011 Mar. PMID 21445332, Free PMC Article
  4. CD46 expression and HHV-6 infection in patients with multiple sclerosis. Alvarez-Lafuente R, et al. Acta Neurol Scand, 2009 Oct. PMID 19456309
  5. Activation of intrarenal complement system in mouse model for chronic cyclosporine nephrotoxicity. Kim YO, et al. Yonsei Med J, 2007 Jun 30. PMID 17594162, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell mediated immunity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T cell mediated immunity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of complement activation, alternative pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of complement activation, classical pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of memory T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transforming growth factor beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in sequestering of extracellular ligand from receptor ISO
Inferred from Sequence Orthology
more info
  
involved_in single fertilization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in inner acrosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in inner acrosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
membrane cofactor protein
Names
CD46 antigen, complement regulatory protein
CD46 molecule, complement regulatory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019190.1 → NP_062063.1  membrane cofactor protein precursor

    See identical proteins and their annotated locations for NP_062063.1

    Status: PROVISIONAL

    Source sequence(s)
    AB010920
    UniProtKB/Swiss-Prot
    Q9Z0M4
    UniProtKB/TrEMBL
    A0A8I5ZTV7, A6JH46
    Conserved Domains (2) summary
    cd00033
    Location:171 → 233
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam00084
    Location:107 → 166
    Sushi; Sushi repeat (SCR repeat)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    109104122..109134903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250478.5 → XP_006250540.1  membrane cofactor protein isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZMW2, A0A8I5ZTV7
    Related
    ENSRNOP00000079381.1
    Conserved Domains (2) summary
    cd00033
    Location:171 → 233
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam00084
    Location:107 → 166
    Sushi; Sushi repeat (SCR repeat)

  2. XM_008769849.4 → XP_008768071.1  membrane cofactor protein isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZTV7, A0A8L2QSL3
    Related
    ENSRNOP00000053980.4
    Conserved Domains (2) summary
    cd00033
    Location:171 → 233
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam00084
    Location:107 → 166
    Sushi; Sushi repeat (SCR repeat)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0M4.1 GenPept UniProtKB/Swiss-Prot:Q9Z0M4

Gene LinkOut

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