Mc3r melanocortin 3 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mc3rprovided by RGD
Official Full Name: melanocortin 3 receptorprovided by RGD
Primary source: RGD:3056
See related: Ensembl:ENSRNOG00000004451 AllianceGenome:RGD:3056
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables melanocortin receptor activity and peptide hormone binding activity. Involved in several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; homoiothermy; and sodium ion homeostasis. Predicted to be integral component of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in obesity. Orthologous to human MC3R (melanocortin 3 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (181434776..181435873)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (161016347..161017444)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (170252901..170253998)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The increase in hypothalamic nesfatin-1 participates in regulating feeding behavior through the MC3/4R-ERK signaling especially after SG and RYGB.
Title: Hypothalamic nesfatin-1 mediates feeding behavior via MC3/4R-ERK signaling pathway after weight loss in obese Sprague-Dawley rats.
MC3R deficiency caused a reduction of food intake and body weight, whereas at the same time exhibited additive effects on top of MC4R deficiency on lipid and glucose metabolism.
Title: Effects of Melanocortin 3 and 4 Receptor Deficiency on Energy Homeostasis in Rats.
Study demonstrates an arcuate nucleus of the hypothalamus pro-opiomelanocortinergic projection onto ventral tegmental area dopaminergic neurons that modulates motivation for palatable food via activation of melanocortin 3 receptor signaling.
Title: Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward.
in rats immunized with M4R and M3R peptides the sensitivity of ACSS thyrocytes to TSH were decreased, whereas in rats iimunized with 5-HT1BR peptide the deficit of thyroid hormones was associated with decreased level of TSH
Title: [THE THYROID STATUS OF RATS IMMUNIZED WITH PEPTIDES DERIVED FROM THE EXTRACELLULAR REGIONS OF THE TYPES 3 AND 4 MELANOCORTIN RECEPTORS AND THE 1B-SUBTYPE 5-HYDROXYTRYPTAMINE RECEPTOR].
We showed that the melanocortin-3/4 receptor antagonist SHU 9119 attenuates the food intake-suppressive effect of aminoprocalcitonin.
Title: Aminoprocalcitonin-mediated suppression of feeding involves the hypothalamic melanocortin system.
Results indicate that activation of MC3/4Rs in the paraventricular nucleus increases the sympathetic outflow and blood pressure via the cAMP-protein kinase A pathway.
Title: Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure.
Compared with low-activity rats, high-activity rats show enhanced mRNA expression of MCRs in the brain, specifically of MC3R in the paraventricular nucleus.
Title: Region-specific differences in brain melanocortin receptors in rats of the lean phenotype.
These results show that immunization against the melanocortin-3 receptor resulted in the production of Abs with positive or negative allosteric properties.
Title: Antibodies raised against different extracellular loops of the melanocortin-3 receptor affect energy balance and autonomic function in rats.
Data are consistent with the view that energetic and feeding responses are not controlled by regionally divergent MC3/4Rs and can be elicited from multiple, anatomically distributed MC3/4R populations.
Title: Hypothalamic and hindbrain melanocortin receptors contribute to the feeding, thermogenic, and cardiovascular action of melanocortins.
Efforts revealed a sequence consistent with that predicted by the rat genome, but different from the published receptor by three amino acids, all of which were located in the predicted second transmembrane domain.
Title: Rattus norvegicus melanocortin 3 receptor: a corrected sequence.

Submit: New GeneRIF Correction See all GeneRIFs (26)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables melanocortin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables melanocortin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables melanocyte-stimulating hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables melanocyte-stimulating hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide hormone binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in homoiothermy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	ISO Inferred from Sequence Orthology more info
involved_in locomotor rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of feeding behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion homeostasis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: melanocortin receptor 3

Names: MC3-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025270.4 → NP_001020441.3 melanocortin receptor 3

See identical proteins and their annotated locations for NP_001020441.3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P32244, Q4KXA4

Related

ENSRNOP00000005871.3, ENSRNOT00000005871.5

Conserved Domains (1) summary

cd15352
Location:39 → 310

7tmA_MC3R; melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors