Mybpc2 myosin binding protein C2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mybpc2provided by RGD
Official Full Name: myosin binding protein C2provided by RGD
Primary source: RGD:1311596
See related: Ensembl:ENSRNOG00000019627 AllianceGenome:RGD:1311596
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to act upstream of or within muscle contraction. Orthologous to human MYBPC2 (myosin binding protein C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 10046.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (104130642..104154101, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (94994121..95017584, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (100506704..100530201, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF403927 (e-PCR)
- UniSTS:246532

RH133264 (e-PCR)
- UniSTS:216547

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in M band	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular non-membrane-bounded organelle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myosin-binding protein C, fast-type

Names: myosin binding protein C, fast-type

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395062.1 → NP_001381991.1 myosin-binding protein C, fast-type

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6JAQ4, D3ZA38

Related

ENSRNOP00000062025.1, ENSRNOT00000067754.2

Conserved Domains (8) summary

smart00410
Location:444 → 506

IG_like; Immunoglobulin like

cd00063
Location:636 → 722

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1045 → 1134

I-set; Immunoglobulin I-set domain

pfam18362
Location:210 → 243

THB; Tri-helix bundle domain

cd00096
Location:257 → 259

Ig; Ig strand A [structural motif]

cd05748
Location:846 → 926

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

cd05894
Location:547 → 632

Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)

cl11960
Location:257 → 338

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

104130642..104154101 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104805.2 → XP_038960733.1 myosin-binding protein C, fast-type isoform X1

UniProtKB/TrEMBL

A6JAQ4, D3ZA38

Conserved Domains (8) summary

smart00410
Location:459 → 521

IG_like; Immunoglobulin like

cd00063
Location:651 → 737

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:1060 → 1149

I-set; Immunoglobulin I-set domain

pfam18362
Location:225 → 258

THB; Tri-helix bundle domain

cd00096
Location:272 → 274

Ig; Ig strand A [structural motif]

cd05748
Location:861 → 941

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

cd05894
Location:562 → 647

Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)

cl11960
Location:272 → 353

Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106257.1: Suppressed sequence

Description

NM_001106257.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.