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Map4k1 mitogen activated protein kinase kinase kinase kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292763, updated on 11-Apr-2024

Summary

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Official Symbol
Map4k1provided by RGD
Official Full Name
mitogen activated protein kinase kinase kinase kinase 1provided by RGD
Primary source
RGD:1305463
See related
Ensembl:ENSRNOG00000020505 AllianceGenome:RGD:1305463
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hpk1
Summary
Predicted to enable ATP binding activity and MAP kinase kinase kinase kinase activity. Predicted to be involved in several processes, including JNK cascade; cellular response to phorbol 13-acetate 12-myristate; and protein phosphorylation. Used to study transient cerebral ischemia. Orthologous to human MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 137.9), Thymus (RPKM 92.1) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q21
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93398460..93419996)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84270951..84292496)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (87937126..87959514)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene calpain 12 Neighboring gene actinin alpha 4 Neighboring gene eukaryotic translation initiation factor 3, subunit K Neighboring gene ryanodine receptor 1 Neighboring gene RAS guanyl releasing protein 4 Neighboring gene family with sequence similarity 98, member C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression. Li T, et al. Neuroreport, 2008 Apr 16. PMID 18382279
  2. Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region. Li T, et al. FEBS Lett, 2008 Jun 11. PMID 18498770
  3. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Hu MC, et al. Genes Dev, 1996 Sep 15. PMID 8824585
  4. The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation. Leung IW, et al. J Biol Chem, 2001 Jan 19. PMID 11053428
  5. HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. Kiefer F, et al. EMBO J, 1996 Dec 16. PMID 9003777, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The tyrosine phosphorylation of HPK1 promotes ischemic brain injury by activated Src via N-methyl-d-aspartate receptor and, ultimately, the activation of the MLK3-MKK7-JNK3 pathway after cerebral ischemia.
    Title: Tyrosine phosphorylation of HPK1 by activated Src promotes ischemic brain injury in rat hippocampal CA1 region.
  2. knockdown of hematopietic progenitor kinase 1 expression provides neuroprotection
    Title: Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables MAP kinase kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to phorbol 13-acetate 12-myristate ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase kinase 1
Names
hematopoietic progenitor kinase 1
NP_001099713.1
XP_006228778.1
XP_008757344.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106243.1 → NP_001099713.1  mitogen-activated protein kinase kinase kinase kinase 1

    See identical proteins and their annotated locations for NP_001099713.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473979
    UniProtKB/TrEMBL
    A0A8I6A6A3, A6J9M5, D3Z8I4
    Related
    ENSRNOP00000027837.4, ENSRNOT00000027837.7
    Conserved Domains (3) summary
    smart00036
    Location:506 → 813
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:17 → 274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16 → 274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    93398460..93419996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228716.5 → XP_006228778.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A6A3
    Conserved Domains (3) summary
    smart00036
    Location:506 → 812
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:17 → 274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16 → 274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

  2. XM_008759122.4 → XP_008757344.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A6A3
    Conserved Domains (3) summary
    smart00220
    Location:17 → 274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06613
    Location:16 → 274
    STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    cl02434
    Location:517 → 767
    CNH; CNH domain
Nucleotide Protein Strain
Heading Accession and Version

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