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Sars2 seryl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 292759, updated on 5-Mar-2024

Summary

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Official Symbol
Sars2provided by RGD
Official Full Name
seryl-tRNA synthetase 2, mitochondrialprovided by RGD
Primary source
RGD:1309456
See related
Ensembl:ENSRNOG00000019962 AllianceGenome:RGD:1309456
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable serine-tRNA ligase activity and tRNA binding activity. Predicted to be involved in mitochondrial seryl-tRNA aminoacylation. Predicted to be active in mitochondrion. Orthologous to human SARS2 (seryl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 75.8), Heart (RPKM 59.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q21
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93156514..93171943)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84028972..84040725)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (86923769..86935506)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene F-box protein 17 Neighboring gene mitochondrial ribosomal protein S12 Neighboring gene NFKB inhibitor beta Neighboring gene coiled-coil glutamate-rich protein 2 Neighboring gene sirtuin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in the mitochondrial seryl-tRNA synthetase cause hyperuricemia, pulmonary hypertension, renal failure in infancy and alkalosis, HUPRA syndrome. Belostotsky R, et al. Am J Hum Genet, 2011 Feb 11. PMID 21255763, Free PMC Article
  2. Genomic organization, expression, and subcellular localization of mouse mitochondrial seryl-tRNA synthetase. Gibbons WJ Jr, et al. Biochem Biophys Res Commun, 2004 May 7. PMID 15081407
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial seryl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine--tRNA ligase, mitochondrial
Names
seryl-aminoacyl-tRNA synthetase 2
seryl-tRNA synthetase, mitochondrial
NP_001099710.1
XP_063139456.1
XP_063139457.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106240.1 → NP_001099710.1  serine--tRNA ligase, mitochondrial

    See identical proteins and their annotated locations for NP_001099710.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473979
    UniProtKB/TrEMBL
    A0A8I5ZQR8, A6J9K5, D3ZM09
    Related
    ENSRNOP00000027166.4, ENSRNOT00000027166.7
    Conserved Domains (3) summary
    PRK05431
    Location:67 → 493
    PRK05431; seryl-tRNA synthetase; Provisional
    cd00770
    Location:185 → 485
    SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
    cl12057
    Location:67 → 172
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    93156514..93171943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283386.1 → XP_063139456.1  serine--tRNA ligase, mitochondrial isoform X1

  2. XM_063283387.1 → XP_063139457.1  serine--tRNA ligase, mitochondrial isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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