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Fpr1 formyl peptide receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 292409, updated on 5-Mar-2024

Summary

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Official Symbol
Fpr1provided by RGD
Official Full Name
formyl peptide receptor 1provided by RGD
Primary source
RGD:1310883
See related
Ensembl:ENSRNOG00000011174 AllianceGenome:RGD:1310883
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables RAGE receptor binding activity and scavenger receptor binding activity. Predicted to be involved in several processes, including complement receptor mediated signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in cytoplasm and plasma membrane. Orthologous to human FPR1 (formyl peptide receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 5.7), Spleen (RPKM 2.4) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (67417991..67429813, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (58745019..58756776, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (59759025..59767258)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene sperm acrosome associated 6 Neighboring gene microRNA 125a Neighboring gene hyaluronan synthase 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108349528 Neighboring gene formyl peptide receptor 2 Neighboring gene formyl peptide receptor 2, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Formyl peptide receptor 1 promotes podocyte injury through regulation of mitogen-activated protein kinase pathways. Zhang J, et al. Exp Biol Med (Maywood), 2022 Jan. PMID 34565207, Free PMC Article
  2. Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells. Wang G, et al. Sci Rep, 2016 May 13. PMID 27173446, Free PMC Article
  3. Lead optimisation of pyrazoles as novel FPR1 antagonists. Morley AD, et al. Bioorg Med Chem Lett, 2012 Jan 1. PMID 22094028
  4. Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells. Chen JH, et al. Biochem Biophys Res Commun, 2006 Apr 21. PMID 16516855
  5. Annexin-1 Mediates Microglial Activation and Migration via the CK2 Pathway during Oxygen-Glucose Deprivation/Reperfusion. Liu S, et al. Int J Mol Sci, 2016 Oct 22. PMID 27782092, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Formyl peptide receptor 1 promotes podocyte injury through regulation of mitogen-activated protein kinase pathways.
    Title: Formyl peptide receptor 1 promotes podocyte injury through regulation of mitogen-activated protein kinase pathways.
  2. Reports showed that both Fpr1 and Fpr2 are expressed on NSCs and both receptors mediate the migration of neural stem cells (NSCs) in vitro and in vivo, and promote the differentiation of NSCs to neuron through F-actin polymerization.
    Title: Formylpeptide Receptors Promote the Migration and Differentiation of Rat Neural Stem Cells.
  3. ANXA1 promotes microglial activation and migration during oxygen-glucose deprivation/reperfusion via FPR, and CK2 target alpha-E-catenin phosphorylation is involved in this process.
    Title: Annexin-1 Mediates Microglial Activation and Migration via the CK2 Pathway during Oxygen-Glucose Deprivation/Reperfusion.
  4. analysis of pyrazoles as novel FPR1 antagonists
    Title: Lead optimisation of pyrazoles as novel FPR1 antagonists.
  5. Our results suggest that Nordy was capable of reducing the level of malignancy of glioma cells.
    Title: Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables N-formyl peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-formyl peptide receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables RAGE receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables complement receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables scavenger receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fMet-Leu-Phe receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106216.1 → NP_001099686.1  fMet-Leu-Phe receptor

    See identical proteins and their annotated locations for NP_001099686.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474033
    UniProtKB/TrEMBL
    A6KB73, D4A7Q2
    Conserved Domains (1) summary
    pfam00001
    Location:45 → 305
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    67417991..67429813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103536.2 → XP_038959464.1  fMet-Leu-Phe receptor isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:30 → 56
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:29 → 144
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_006227988.5 → XP_006228050.1  fMet-Leu-Phe receptor isoform X1

    See identical proteins and their annotated locations for XP_006228050.1

    UniProtKB/TrEMBL
    A6KB73, D4A7Q2
    Related
    ENSRNOP00000014841.2
    Conserved Domains (1) summary
    pfam00001
    Location:45 → 305
    7tm_1; 7 transmembrane receptor (rhodopsin family)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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