Thbs2 thrombospondin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Thbs2provided by RGD
Official Full Name: thrombospondin 2provided by RGD
Primary source: RGD:1310979
See related: Ensembl:ENSRNOG00000010529 AllianceGenome:RGD:1310979
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TSP-2
Summary: Predicted to enable calcium ion binding activity and heparin binding activity. Involved in negative regulation of angiogenesis and positive regulation of synapse assembly. Predicted to be located in basement membrane and platelet alpha granule. Predicted to be active in collagen-containing extracellular matrix. Orthologous to human THBS2 (thrombospondin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 228.2), Muscle (RPKM 141.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (64343523..64372918, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (55670394..55699789, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (56653929..56683571, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thrombospondin-2 Couples Pressure-Promoted Chondrogenesis through NF-kappaB Signaling.
Title: Thrombospondin-2 Couples Pressure-Promoted Chondrogenesis through NF-κB Signaling.
The expression levels of glial fibrillary acidic protein (the marker of activated macroglia cells), thrombospondin 2, alpha2delta-1 and presynaptic proteins were increased following elevated hydrostatic pressure in mixed cultures, but the expression levels of postsynaptic proteins were not changed.
Title: Macroglia-derived thrombospondin 2 regulates alterations of presynaptic proteins of retinal neurons following elevated hydrostatic pressure.
In the adult rat retina, TSP2, but not TSP1, secreted by glial cells may be involved in the synaptic plastic process after retinal injury through binding to its neuronal receptor alpha2delta1.
Title: Distribution of thrombospondins and their neuronal receptor α2δ1 in the rat retina.
Intracerebral hemorrhage induced an increase in the expression of TSP-2 mRNA. Thrombin induced TSP-2 expression in the blood vessels around the ICH.
Title: Thrombin promotes the expression of thrombospondin-1 and -2 in a rat model of intracerebral hemorrhage.
intracerebral hemorrhage can alter the expression of TSP-1 and TSP-2, which may be involved in modulating angiogenesis in brains following intracerebral hemorrhage
Title: Alteration of thrombospondin-1 and -2 in rat brains following experimental intracerebral hemorrhage. Laboratory investigation.
Expression of mRNA for thrombospondins (TSP-1, TSP-2, TSP-4) was greater than 5-fold higher in vena cava versus thoracic aorta.
Title: Differential expression of pancreatitis-associated protein and thrombospondins in arterial versus venous tissues.
Findings show that the blockade of NF-kappaB activation by WT ODN decoy prevents the development of granulation tissue and upregulates Bax as well as TSP-1 and TSP-2 expression.
Title: NF-kappaB blockade upregulates Bax, TSP-1, and TSP-2 expression in rat granulation tissue.
Robust expression of TSP-1 and TSP-2, two major angiostatic factors, was noted in the ischemic brain with different temporal expression profiles from different cellular origins.
Title: Differential regulation of thrombospondin-1 and thrombospondin-2 after focal cerebral ischemia/reperfusion.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Thbs2 (e-PCR), detects polymorphism
- UniSTS:532692

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of angiogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basement membrane	ISO Inferred from Sequence Orthology more info
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in platelet alpha granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thrombospondin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001169138.1 → NP_001162609.1 thrombospondin-2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

D4A2G6

Related

ENSRNOP00000014552.6, ENSRNOT00000014552.8

Conserved Domains (10) summary

smart00209
Location:497 → 549

TSP1; Thrombospondin type 1 repeats

smart00210
Location:22 → 213

TSPN; Thrombospondin N-terminal -like domains

sd00001
Location:847 → 884

TSP3; TSP3 repeat_long [structural motif]

sd00002
Location:789 → 823

TSP3; TSP3 repeat_long [structural motif]

sd00003
Location:693 → 728

TSP3_1C; TSP3 repeat_1C [structural motif]

pfam00090
Location:385 → 430

TSP_1; Thrombospondin type 1 domain

pfam00093
Location:320 → 374

VWC; von Willebrand factor type C domain

pfam02412
Location:848 → 884

TSP_3; Thrombospondin type 3 repeat

pfam05735
Location:974 → 1171

TSP_C; Thrombospondin C-terminal region

pfam12947
Location:652 → 691

EGF_3; EGF domain