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Galr3 galanin receptor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29235, updated on 11-Apr-2024

Summary

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Official Symbol
Galr3provided by RGD
Official Full Name
galanin receptor 3provided by RGD
Primary source
RGD:2658
See related
Ensembl:ENSRNOG00000027060 AllianceGenome:RGD:2658
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables galanin receptor activity. Involved in neuropeptide signaling pathway. Predicted to be located in non-motile cilium. Predicted to be integral component of plasma membrane. Orthologous to human GALR3 (galanin receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 2.3), Lung (RPKM 2.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q34
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112483183..112496359)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110603525..110608429)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120271451..120276243)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene H1.0 linker histone Neighboring gene glycine C-acetyltransferase Neighboring gene ankyrin repeat domain 54 Neighboring gene transfer RNA valine (anticodon AAC) 17 Neighboring gene eukaryotic translation initiation factor 3, subunit L

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Restricted distribution of galanin receptor 3 (GalR3) mRNA in the adult rat central nervous system. Mennicken F, et al. J Chem Neuroanat, 2002 Nov. PMID 12406501
  2. Distribution of galanin-1, -2 and -3 receptor messenger RNAs in central and peripheral rat tissues. Waters SM, et al. Neuroscience, 2000. PMID 10619483
  3. Cloning and expressional characterization of a novel galanin receptor. Identification of different pharmacophores within galanin for the three galanin receptor subtypes. Wang S, et al. J Biol Chem, 1997 Dec 19. PMID 9405385
  4. A clonal rat pancreatic delta cell line (Rin14B) expresses a high number of galanin receptors negatively coupled to a pertussis-toxin-sensitive cAMP-production pathway. Amiranoff B, et al. Eur J Biochem, 1991 Jan 30. PMID 1847683
  5. Effects of intracerebroventricular galanin or a galanin receptor 2/3 agonist on the lesion induced by transient occlusion of the middle cerebral artery in female rats. Holm L, et al. Neuropeptides, 2011 Feb. PMID 20974494

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that a galanin or a galanin receptor R2/3 agonist doubles the size of the ischemic lesion following middle cerebral artery occlusion in rats.
    Title: Effects of intracerebroventricular galanin or a galanin receptor 2/3 agonist on the lesion induced by transient occlusion of the middle cerebral artery in female rats.
  2. the efficacy of galanin to induce an effective coupling of its receptors to G proteins could be different depending on the brain area
    Title: G protein-coupled galanin receptor distribution in the rat central nervous system.
  3. distribution of GalR3 is contradictory and most studies demonstrated a low expression levels in the rat brain
    Title: Distribution and differential regulation of galanin receptor subtypes in rat brain: effects of seizure activity.
  4. The neuroanatomical distribution of GalR3 suggests it might be involved in mediating documented effects of galanin on food intake, fluid homeostasis, cardiovascular function and nociception.
    Title: Restricted distribution of galanin receptor 3 (GalR3) mRNA in the adult rat central nervous system.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables galanin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galanin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galanin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables galanin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide hormone binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide hormone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in galanin-activated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in galanin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in non-motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in non-motile cilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
galanin receptor type 3
Names
GAL3-R
GALR-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019173.1 → NP_062046.1  galanin receptor type 3

    See identical proteins and their annotated locations for NP_062046.1

    Status: PROVISIONAL

    Source sequence(s)
    AF073798
    UniProtKB/Swiss-Prot
    O54914, O88626, Q9QWZ2
    UniProtKB/TrEMBL
    A0A140TAA9
    Related
    ENSRNOP00000014349.5, ENSRNOT00000014349.6
    Conserved Domains (2) summary
    pfam00001
    Location:34 → 291
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:24 → 162
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    112483183..112496359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241972.4 → XP_006242034.1  galanin receptor type 3 isoform X1

    See identical proteins and their annotated locations for XP_006242034.1

    UniProtKB/Swiss-Prot
    O54914, O88626, Q9QWZ2
    UniProtKB/TrEMBL
    A0A140TAA9
    Conserved Domains (2) summary
    pfam00001
    Location:34 → 291
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:24 → 162
    7tm_4; Olfactory receptor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88626.1 GenPept UniProtKB/Swiss-Prot:O88626

Gene LinkOut

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