Chad chondroadherin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chadprovided by RGD
Official Full Name: chondroadherinprovided by RGD
Primary source: RGD:2336
See related: Ensembl:ENSRNOG00000003304 AllianceGenome:RGD:2336
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in cartilage condensation. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human CHAD (chondroadherin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 19.9), Muscle (RPKM 18.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (80009045..80012816)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (79512170..79515941)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (82290296..82296146)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in bone development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
involved_in cartilage condensation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of bone trabecula formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of bone trabecula formation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chondroadherin

Names: cartilage leucine-rich protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019164.2 → NP_062037.1 chondroadherin precursor

See identical proteins and their annotated locations for NP_062037.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

O70210

UniProtKB/TrEMBL

A0A0H2UHB8, A6HI58

Related

ENSRNOP00000004435.3, ENSRNOT00000004435.5

Conserved Domains (5) summary

smart00082
Location:299 → 346

LRRCT; Leucine rich repeat C-terminal domain

cd00116
Location:89 → 281

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:52 → 75

LRR_RI; leucine-rich repeat [structural motif]

pfam01462
Location:22 → 48

LRRNT; Leucine rich repeat N-terminal domain

pfam13855
Location:74 → 134

LRR_8; Leucine rich repeat