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Mmp15 matrix metallopeptidase 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291848, updated on 13-Apr-2024

Summary

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Official Symbol
Mmp15provided by RGD
Official Full Name
matrix metallopeptidase 15provided by RGD
Primary source
RGD:1308937
See related
Ensembl:ENSRNOG00000012622 AllianceGenome:RGD:1308937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metalloendopeptidase activity. Involved in response to estradiol. Predicted to be located in extracellular matrix. Predicted to be integral component of plasma membrane. Orthologous to human MMP15 (matrix metallopeptidase 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 182.1), Lung (RPKM 163.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19p13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (9669506..9691000, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (9663449..9684943, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10079881..10101380, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene casein kinase 2 alpha 2 Neighboring gene cilia and flagella associated protein 20 Neighboring gene U6 snRNA biogenesis phosphodiesterase 1 Neighboring gene zinc finger protein 319

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues. Riddick AC, et al. Br J Cancer, 2005 Jun 20. PMID 15928670, Free PMC Article
  2. Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human urothelial carcinomas. Kitagawa Y, et al. J Urol, 1998 Oct. PMID 9751409
  3. Insulin receptor substrate 2 plays important roles in 17beta-estradiol-induced bone formation. Bu YH, et al. J Endocrinol Invest, 2009 Sep. PMID 19509476
  4. [Selection of the early stage differentially expressed genes in rat lung tissue by cDNA microarray after total hepatic ischemia reperfusion injury]. Zhao D, et al. Zhonghua Wai Ke Za Zhi, 2009 Mar 1. PMID 19595018
  5. Expression pattern of four membrane-type matrix metalloproteinases in the normal and diseased mouse mammary gland. Szabova L, et al. J Cell Physiol, 2005 Oct. PMID 15895410

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
matrix metalloproteinase-15
Names
matrix metalloproteinase 15
NP_001099638.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106168.2 → NP_001099638.1  matrix metalloproteinase-15 precursor

    See identical proteins and their annotated locations for NP_001099638.1

    Status: VALIDATED

    Source sequence(s)
    CB545319, CB773519, CK357842, JAXUCZ010000019
    UniProtKB/TrEMBL
    A6JY10, D3ZCG5
    Related
    ENSRNOP00000017629.5, ENSRNOT00000017629.7
    Conserved Domains (5) summary
    cd00094
    Location:363 → 555
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:135 → 300
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:135 → 300
    Peptidase_M10; Matrixin
    pfam01471
    Location:42 → 102
    PG_binding_1; Putative peptidoglycan binding domain
    pfam11857
    Location:632 → 657
    DUF3377; Domain of unknown function (DUF3377)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    9669506..9691000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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