Myog myogenin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myogprovided by RGD
Official Full Name: myogeninprovided by RGD
Primary source: RGD:620432
See related: Ensembl:ENSRNOG00000030743 AllianceGenome:RGD:620432
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: This gene belongs to the myogenic factor subfamily of the basic helix-loop-helix (BHLH) family of transcription factors. The protein encoded by this gene is a muscle-specific skeletal myogenin, which acts in concert with other family members to regulate myogenesis. The protein plays an essential role in the conversion of undifferentiated cells to myoblasts and functional skeletal muscle. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward (RPKM 151.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (48297476..48300065)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (45745455..45748044)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (51126459..51129048)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of skeletal myogenesis in C2C12 cells through modulation of Pax7, MyoD, and myogenin via different low-frequency electromagnetic field energies.
Title: Regulation of skeletal myogenesis in C2C12 cells through modulation of Pax7, MyoD, and myogenin via different low-frequency electromagnetic field energies.
low-level laser therapy (LLLT) administered following muscle injury modulates the mRNA expression of MyoD and myogenin. Moreover, the both forms of LLLT administration were able to modulate the mRNA expression of IL-6 during the muscle repair process.
Title: Comparative effects of low-level laser therapy pre- and post-injury on mRNA expression of MyoD, myogenin, and IL-6 during the skeletal muscle repair.
Suggest that myogenin is the target for doxorubicin-induced cardio-toxicity.
Title: The regulatory mechanisms of myogenin expression in doxorubicin-treated rat cardiomyocytes.
Myogenin, which is expressed in MPCs, belongs to a family of basic helix-loop-helix transcription factors that activate skeletal muscle differentiation and thus plays a key role in fetal diaphragmatic development and muscularization.
Title: Myogenin gene expression is not altered in the developing diaphragm of nitrofen-induced congenital diaphragmatic hernia.
Myogenin, myostatin, and follistatin expression is lower and MRF4 levels higher in spontaneously hypertensive rats (SHR)
Title: Heart failure-induced skeletal myopathy in spontaneously hypertensive rats.
Sema3A is a crucial factor that is up-stream of the muscle-specific transcription factor, myogenin.
Title: Comparative analysis of semaphorin 3A in soleus and EDL muscle satellite cells in vitro toward understanding its role in modulating myogenin expression.
Expression of Myod and myogenin is increased in skeletal muscle of rats fed magnesium-deficient diet.
Title: Magnesium deficiency up-regulates Myod expression in rat skeletal muscle and C2C12 myogenic cells.
Results describe the involvement of myogenin and GATA4, two tissue-specific transcription factors, and the atrial natriuretic factor promoter, in cardiac transcriptional activity.
Title: Myogenic differentiation in atrium-derived adult cardiac pluripotent cells and the transcriptional regulation of GATA4 and myogenin on ANP promoter.
The mechanical ventilation-induced reduction in diaphragm MyoD and myogenin protein expression was attenuated after corticosteroids.
Title: Effects of acute administration of corticosteroids during mechanical ventilation on rat diaphragm.
Myogenin gene expression in developing plantaris and soleus muscles was significantly reduced (P < 0.001) in microgravity
Title: Effects of microgravity on myogenic factor expressions during postnatal development of rat skeletal muscle.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Markers

UniSTS:463953 (e-PCR)
- UniSTS:463953

Myog (e-PCR), detects polymorphism
- UniSTS:463953

PMC133893P1 (e-PCR)
- UniSTS:270678

PMC207566P7 (e-PCR)
- UniSTS:271960

Myog (e-PCR), detects polymorphism
- UniSTS:143980

Myog (e-PCR), detects polymorphism
- UniSTS:143981

Myog (e-PCR), detects polymorphism
- UniSTS:143982

Myog (e-PCR), detects polymorphism
- UniSTS:143983

UniSTS:205458 (e-PCR)
- UniSTS:205458

Myog (e-PCR), detects polymorphism
- UniSTS:205458

Myog (e-PCR), detects polymorphism
- UniSTS:265671

UniSTS:234220 (e-PCR)
- UniSTS:234220

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IEA Inferred from Electronic Annotation more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables E-box binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to estradiol stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to estradiol stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lithium ion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to lithium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to magnetism	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle organ development	ISO Inferred from Sequence Orthology more info
involved_in myoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in myotube differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of glycolytic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ossification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ossification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of muscle atrophy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of muscle atrophy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of muscle atrophy	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of myoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myotube differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myotube differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of oxidative phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of skeletal muscle fiber development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of skeletal muscle fiber development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of skeletal muscle fiber development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle fiber development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of myoblast fusion	IEA Inferred from Electronic Annotation more info
involved_in regulation of myoblast fusion	ISO Inferred from Sequence Orthology more info
involved_in regulation of myoblast fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of skeletal muscle satellite cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of skeletal muscle satellite cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of skeletal muscle satellite cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to denervation involved in regulation of muscle adaptation	IEA Inferred from Electronic Annotation more info
involved_in response to denervation involved in regulation of muscle adaptation	ISO Inferred from Sequence Orthology more info
involved_in response to denervation involved in regulation of muscle adaptation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to electrical stimulus involved in regulation of muscle adaptation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to electrical stimulus involved in regulation of muscle adaptation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gravity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle activity involved in regulation of muscle adaptation	IDA Inferred from Direct Assay more info	PubMed
involved_in skeletal muscle atrophy	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal muscle cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle fiber development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle fiber development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in striated muscle atrophy	IEA Inferred from Electronic Annotation more info
involved_in striated muscle atrophy	ISO Inferred from Sequence Orthology more info
involved_in striated muscle atrophy	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myogenin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017115.3 → NP_058811.2 myogenin

See identical proteins and their annotated locations for NP_058811.2

Status: REVIEWED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

F7EW09, O70425

Related

ENSRNOP00000039817.1, ENSRNOT00000042046.2

Conserved Domains (2) summary

smart00520
Location:1 → 86

BASIC; Basic domain in HLH proteins of MYOD family

cd18935
Location:81 → 139

bHLH_TS_MYOG_Myf4; basic helix-loop-helix (bHLH) domain found in myogenin (MYOG) and similar proteins