NR3C1 nuclear receptor subfamily 3 group C member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NR3C1provided by HGNC
Official Full Name: nuclear receptor subfamily 3 group C member 1provided by HGNC
Primary source: HGNC:HGNC:7978
See related: Ensembl:ENSG00000113580 MIM:138040; AllianceGenome:HGNC:7978
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GR; GCR; GRL; GCCR; GCRST
Summary: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
Expression: Ubiquitous expression in fat (RPKM 11.8), lung (RPKM 9.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q31.3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (143277931..143435512, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (143809293..143966896, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (142657496..142815077, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Methylation of the Glucocorticoid Receptor Gene (NR3C1) in Adolescents with a History of Childhood Adversity Engaging in Non-Suicidal Self-Injury.
Title: Methylation of the Glucocorticoid Receptor Gene (NR3C1) in Adolescents with a History of Childhood Adversity Engaging in Non-Suicidal Self-Injury.
Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer.
Title: Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer.
Chromatin accessibility and pioneer factor FOXA1 restrict glucocorticoid receptor action in prostate cancer.
Title: Chromatin accessibility and pioneer factor FOXA1 restrict glucocorticoid receptor action in prostate cancer.
The glucocorticoid receptor gene (NR3C1) is linked to and associated with polycystic ovarian syndrome in Italian families.
Title: The glucocorticoid receptor gene (NR3C1) is linked to and associated with polycystic ovarian syndrome in Italian families.
Decreased mononuclear cell NR3C1 SKA2 and FKPB5 expression levels among adult survivors of suicide bombing terror attacks in childhood are associated with the development of PTSD.
Title: Decreased mononuclear cell NR3C1 SKA2 and FKPB5 expression levels among adult survivors of suicide bombing terror attacks in childhood are associated with the development of PTSD.
Luminal breast cancer identity is determined by loss of glucocorticoid receptor activity.
Title: Luminal breast cancer identity is determined by loss of glucocorticoid receptor activity.
A Genomic Study of the Japanese Population Focusing on the Glucocorticoid Receptor Interactome Highlights Distinct Genetic Characteristics Associated with Stress Response.
Title: A Genomic Study of the Japanese Population Focusing on the Glucocorticoid Receptor Interactome Highlights Distinct Genetic Characteristics Associated with Stress Response.
Polymorphism of glucocorticoid receptor gene (rs41423247) in functional seizures (psychogenic nonepileptic seizures/attacks).
Title: Polymorphism of glucocorticoid receptor gene (rs41423247) in functional seizures (psychogenic nonepileptic seizures/attacks).
Promoter methylation of the glucocorticoid receptor following trauma may be associated with subsequent development of PTSD.
Title: Promoter methylation of the glucocorticoid receptor following trauma may be associated with subsequent development of PTSD.
DNMT1-mediated NR3C1 DNA methylation enables transcription activation of connexin40 and augments angiogenesis during colorectal cancer progression.
Title: DNMT1-mediated NR3C1 DNA methylation enables transcription activation of connexin40 and augments angiogenesis during colorectal cancer progression.

Submit: New GeneRIF Correction See all GeneRIFs (851)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Glucocorticoid resistance MedGen: C1841972 OMIM: 615962 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies new susceptibility loci for migraine. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	Glucocorticoid receptor (GR) agonists, dexamethasone (Dex) and medroxyprogesterone acetate (MPA), enhance HIV-1 Vpr peptide (amino acids 52-96)-mediated apoptosis of CD4+ T-cells in a GR-dependent manner	PubMed
	vpr	HIV-1 Vpr leucine residues mediate Vpr-Glucocorticoid Receptor (GR) interaction and promoter transactivation; mutation at residue L22 results in 8- to 11-fold higher GRE and HIV-1 LTR transactivation, while L42 and L67 mutants showed reduced activation	PubMed
	vpr	HIV-1 Vpr activates transcription of glucocorticoid-responsive promoters by binding directly to p300/CBP co-activators, forming a stable complex with p300 and interacting with ligand-bound glucocorticoid receptor	PubMed
	vpr	HIV-1 Vpr potentiates the trans-activation, but not the trans-repression, properties of the glucocorticoid receptor on NF-kappa B and activating protein 1-regulated simple promoters	PubMed
	vpr	HIV-1 Vpr (amino acids 22-26 and 64-68) binds to and activates glucocorticoid receptor (GR) and transactivates the HIV-1 LTR promoter through the host GR pathway	PubMed
	vpr	HIV-1 Vpr targets the glucocorticoid receptor type II complex through an interaction with Vpr interacting protein 1 (Rip-1), a 41 kDa cytosolic protein that binds to Vpr and in a complex with the human glucocorticoid receptor	PubMed
	vpr	HIV-1 Vpr affects the gene expression of glucocorticoid-regulated genes (IL-12, CD44, Toll-like receptor 4 and indolamine 2,3-dioxygenase, macrophage receptor with collagenous structure, and thrombospondin 1) through activation of the GR pathway	PubMed
	vpr	Studies suggest effects of HIV-1 Vpr on cytokine expression (IL-2, IL-10, IL-12, TNFalpha and IL-4) and T-cell proliferation may be mediated through activation of the glucocorticoid receptor pathway	PubMed
	vpr	Interaction of HIV-1 Vpr and hVIP/mov34 may be involved in the activation of glucocorticoid receptor by Vpr	PubMed
	vpr	Transcription factors TFIIH, CDK7, Cyclin H, and MAT1 enhance HIV-1 Vpr activation of glucocorticoid receptor	PubMed
	vpr	HIV-1 Vpr synergistically enhances SRC-1 ligand-activated glucocorticoid receptor activity	PubMed
	vpr	HIV-1 Vpr (amino acids 1-35) binds to TFIID, an interaction that is associated with the ability of Vpr to stimulate transcription through the glucocorticoid receptor pathway	PubMed
	vpr	Specific binding of HIV-1 Vpr (amino acids 15-35) to TFIIB (amino acids 52-55) causes a conformational change in TFIIB and is correlated with the ability of Vpr to stimulate transcription through the glucocorticoid receptor pathway	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G42349 (e-PCR)
- UniSTS:94208

RH104235 (e-PCR)
- UniSTS:98560

PMC64995P2 (e-PCR)
- UniSTS:273428

NR3C1_1004 (e-PCR)
- UniSTS:277539

NR3C1_V270 (e-PCR)
- UniSTS:277539

NR3C1 (e-PCR)
- UniSTS:504891

STS-U25029 (e-PCR)
- UniSTS:57947

D5S2378 (e-PCR)
- UniSTS:3680

SHGC-58162 (e-PCR)
- UniSTS:33390

L31444 (e-PCR)
- UniSTS:10390

RH68907 (e-PCR)
- UniSTS:74908

Nr3c1 (e-PCR), detects polymorphism
- UniSTS:143264

D5S2472 (e-PCR)
- UniSTS:9903

bac51148T (e-PCR)
- UniSTS:181430

SHGC-110504 (e-PCR)
- UniSTS:167866

SHGC-111096 (e-PCR)
- UniSTS:168137

G65702 (e-PCR)
- UniSTS:225496

RH16558 (e-PCR)
- UniSTS:26336

D5S1871 (e-PCR)
- UniSTS:35571

bac51616T (e-PCR)
- UniSTS:181493

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables Hsp90 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables TBP-class protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables nuclear glucocorticoid receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables steroid binding	IDA Inferred from Direct Assay more info	PubMed
enables steroid hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adrenal gland development	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in astrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to dexamethasone stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to steroid hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in glucocorticoid mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in glucocorticoid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucocorticoid receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in intracellular steroid hormone receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in mammary gland duct morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in maternal behavior	IEA Inferred from Electronic Annotation more info
involved_in microglia differentiation	IEA Inferred from Electronic Annotation more info
involved_in motor behavior	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroinflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of glucocorticoid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	TAS Traceable Author Statement more info	PubMed
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glucocorticoid receptor

Names: nuclear receptor subfamily 3 group C member 1 variant hGR-B(54); nuclear receptor subfamily 3 group C member 1 variant hGR-B(77); nuclear receptor subfamily 3 group C member 1 variant hGR-B(93); nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009062.1 RefSeqGene

Range

36827..162579

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000176.3 → NP_000167.1 glucocorticoid receptor isoform alpha

See identical proteins and their annotated locations for NP_000167.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript, and encodes the predominant physiological isoform (alpha, also known as GRalpha or GR-A). Variants 1-5 encode the same isoform.

Source sequence(s)

AC004782, AC091925, X03225

Consensus CDS

CCDS4278.1

UniProtKB/Swiss-Prot

A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4

UniProtKB/TrEMBL

A0A5B9RIM3, F1D8N4

Related

ENSP00000377977.2, ENST00000394464.7

Conserved Domains (3) summary

cd07076
Location:531 → 777

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:417 → 494

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 → 401

GCR; Glucocorticoid receptor
NM_001018074.1 → NP_001018084.1 glucocorticoid receptor isoform alpha

See identical proteins and their annotated locations for NP_001018084.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).

Source sequence(s)

AC004782, AC091925, X03225

Consensus CDS

CCDS4278.1

UniProtKB/Swiss-Prot

A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4

UniProtKB/TrEMBL

A0A5B9RIM3, F1D8N4

Conserved Domains (3) summary

cd07076
Location:531 → 777

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:417 → 494

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 → 401

GCR; Glucocorticoid receptor
NM_001018075.1 → NP_001018085.1 glucocorticoid receptor isoform alpha

See identical proteins and their annotated locations for NP_001018085.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha)

Source sequence(s)

AC004782, AC091925, X03225

Consensus CDS

CCDS4278.1

UniProtKB/Swiss-Prot

A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4

UniProtKB/TrEMBL

A0A5B9RIM3, F1D8N4

Conserved Domains (3) summary

cd07076
Location:531 → 777

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:417 → 494

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 → 401

GCR; Glucocorticoid receptor
NM_001018076.2 → NP_001018086.1 glucocorticoid receptor isoform alpha

See identical proteins and their annotated locations for NP_001018086.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).

Source sequence(s)

AC004782, AC091925, BF966114, X03225

Consensus CDS

CCDS4278.1

UniProtKB/Swiss-Prot

A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4

UniProtKB/TrEMBL

A0A5B9RIM3, F1D8N4

Related

ENSP00000427672.1, ENST00000503201.1

Conserved Domains (3) summary

cd07076
Location:531 → 777

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:417 → 494

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 → 401

GCR; Glucocorticoid receptor
NM_001018077.1 → NP_001018087.1 glucocorticoid receptor isoform alpha

See identical proteins and their annotated locations for NP_001018087.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).

Source sequence(s)

AC004782, AC091925, X03225

Consensus CDS

CCDS4278.1

UniProtKB/Swiss-Prot

A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4

UniProtKB/TrEMBL

A0A5B9RIM3, F1D8N4

Related

ENSP00000343205.2, ENST00000343796.6

Conserved Domains (3) summary

cd07076
Location:531 → 777

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:417 → 494

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 → 401

GCR; Glucocorticoid receptor
NM_001020825.2 → NP_001018661.1 glucocorticoid receptor isoform beta

See identical proteins and their annotated locations for NP_001018661.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (beta, also known as GRbeta) with a distinct C-terminus compared to isoform alpha. This isoform resides primarily in the nucleus, lacks hormone-binding activity, and has a dominant negative effect on the action of isoform alpha (PMID:8621628).

Source sequence(s)

AC004782, AC091925, X03348

Consensus CDS

CCDS47298.1

UniProtKB/TrEMBL

E5KQF5, H6V745

Related

ENSP00000387672.2, ENST00000415690.6

Conserved Domains (3) summary

cd07172
Location:417 → 494

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 → 401

GCR; Glucocorticoid receptor

cl11397
Location:531 → 729

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001024094.2 → NP_001019265.1 glucocorticoid receptor isoform gamma

See identical proteins and their annotated locations for NP_001019265.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) uses an alternate in-frame donor splice site at one of the coding exons compared to variant 1. This results in an isoform (gamma) that is 1 aa longer than isoform alpha. The insertion of an additional amino acid (arginine) in the DNA binding domain has been reported to decrease transcriptional activation by the glucocorticoid receptor (PMID:10566686).

Source sequence(s)

AC004782, AC091925, U01351

Consensus CDS

CCDS34258.1

UniProtKB/TrEMBL

A0A5B9RIM3, E5KQF6

Related

ENSP00000231509.3, ENST00000231509.7

Conserved Domains (3) summary

cd07076
Location:532 → 778

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:417 → 495

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 → 401

GCR; Glucocorticoid receptor
NM_001204258.2 → NP_001191187.1 glucocorticoid receptor isoform alpha-B

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-B, also known as GR-B) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 571-573).

Source sequence(s)

AC004782, AC091925, CA425706, U01351, X03225

UniProtKB/TrEMBL

A0A5B9RIM3

Conserved Domains (3) summary

cd07076
Location:505 → 751

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:391 → 468

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:1 → 375

GCR; Glucocorticoid receptor
NM_001204259.2 → NP_001191188.1 glucocorticoid receptor isoform alpha-C1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C1, also known as GR-C1) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 748-750).

Source sequence(s)

AC004782, AC091925, CA425706, U01351, X03225

UniProtKB/TrEMBL

A0A5B9RIM3

Conserved Domains (3) summary

cd07076
Location:446 → 692

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:332 → 409

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:1 → 316

GCR; Glucocorticoid receptor
NM_001204260.2 → NP_001191189.1 glucocorticoid receptor isoform alpha-C2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C2, also known as GR-C2) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 760-762).

Source sequence(s)

AC004782, AC091925, CA425706, U01351, X03225

UniProtKB/TrEMBL

A0A5B9RIM3

Conserved Domains (3) summary

cd07076
Location:442 → 688

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:328 → 405

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:1 → 312

GCR; Glucocorticoid receptor
NM_001204261.2 → NP_001191190.1 glucocorticoid receptor isoform alpha-C3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternative in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C3, also known as GR-C3) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 784-786).

Source sequence(s)

AC004782, AC091925, CA425706, U01351, X03225

UniProtKB/TrEMBL

A0A5B9RIM3

Conserved Domains (3) summary

cd07076
Location:434 → 680

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:320 → 397

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:1 → 304

GCR; Glucocorticoid receptor
NM_001204262.2 → NP_001191191.1 glucocorticoid receptor isoform alpha-D1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D1, also known as GR-D1) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1438-1440).

Source sequence(s)

AC004782, AC091925, CA425706, U01351, X03225

UniProtKB/TrEMBL

B7Z7I2

Conserved Domains (3) summary

cd07076
Location:216 → 462

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:102 → 179

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:1 → 86

GCR; Glucocorticoid receptor
NM_001204263.2 → NP_001191192.1 glucocorticoid receptor isoform alpha-D2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D2, also known as GR-D2) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1483-1485).

Source sequence(s)

AC004782, AC091925, CA425706, U01351, X03225

UniProtKB/TrEMBL

B7Z7I2

Conserved Domains (3) summary

cd07076
Location:201 → 447

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:87 → 164

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:1 → 71

GCR; Glucocorticoid receptor
NM_001204264.2 → NP_001191193.1 glucocorticoid receptor isoform alpha-D3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D3, also known as GR-D3) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1498-1500).

Source sequence(s)

AC004782, AC091925, CA425706, U01351, X03225

UniProtKB/TrEMBL

B7Z7I2

Conserved Domains (3) summary

cd07076
Location:196 → 442

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:82 → 159

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:1 → 66

GCR; Glucocorticoid receptor
NM_001204265.2 → NP_001191194.1 glucocorticoid receptor isoform GR-P

Status: REVIEWED

Description

Transcript Variant: This variant (8, also known as GR-P) is missing 2 exons from the 3' end, and has a different 3' end compared to variant 1. This results in an isoform (GR-P) with a shorter and unique C-terminus compared to isoform alpha. The function of the encoded protein is not known, however, this variant is highly expressed in cells that are resistant to glucocorticoids, and may act to modulate glucocorticoid responsiveness (PMIDs:7796394, 11358809).

Source sequence(s)

AA737284, AC091925, BF244382, U01351, U25029

UniProtKB/TrEMBL

F5ATB8

Conserved Domains (3) summary

cd07172
Location:417 → 494

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 → 401

GCR; Glucocorticoid receptor

cl11397
Location:531 → 674

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001364180.2 → NP_001351109.1 glucocorticoid receptor isoform alpha

Status: REVIEWED

Source sequence(s)

AC004782, AC091925

Consensus CDS

CCDS4278.1

UniProtKB/Swiss-Prot

A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4

UniProtKB/TrEMBL

A0A5B9RIM3, F1D8N4

Conserved Domains (3) summary

cd07076
Location:531 → 777

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:417 → 494

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 → 401

GCR; Glucocorticoid receptor
NM_001364181.2 → NP_001351110.1 glucocorticoid receptor isoform alpha

Status: REVIEWED

Source sequence(s)

AC004782, AC091925

Consensus CDS

CCDS4278.1

UniProtKB/Swiss-Prot

A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4

UniProtKB/TrEMBL

A0A5B9RIM3, F1D8N4

Conserved Domains (3) summary

cd07076
Location:531 → 777

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:417 → 494

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 → 401

GCR; Glucocorticoid receptor
NM_001364182.1 → NP_001351111.1 glucocorticoid receptor isoform alpha

Status: REVIEWED

Source sequence(s)

AC004782, AC091925

Consensus CDS

CCDS4278.1

UniProtKB/Swiss-Prot

A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4

UniProtKB/TrEMBL

A0A5B9RIM3, F1D8N4

Conserved Domains (3) summary

cd07076
Location:531 → 777

NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily

cd07172
Location:417 → 494

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02155
Location:26 → 401

GCR; Glucocorticoid receptor
NM_001364183.2 → NP_001351112.1 glucocorticoid receptor isoform gamma

Status: REVIEWED

Source sequence(s)

AC004782, AC091925, BX648553

Consensus CDS

CCDS34258.1

UniProtKB/TrEMBL

A0A5B9RIM3, E5KQF6

Related

ENSP00000422518.1, ENST00000504572.5
NM_001364184.2 → NP_001351113.1 glucocorticoid receptor isoform gamma

Status: REVIEWED

Source sequence(s)

AC004782, AC091925

Consensus CDS

CCDS34258.1

UniProtKB/TrEMBL

A0A5B9RIM3, E5KQF6

Related

ENSP00000377979.2, ENST00000394466.6
NM_001364185.1 → NP_001351114.1 glucocorticoid receptor isoform gamma

Status: REVIEWED

Source sequence(s)

AC004782, AC091925

Consensus CDS

CCDS34258.1

UniProtKB/TrEMBL

A0A5B9RIM3, E5KQF6